CEFTAZIDIME


Trade Names	CEFTAZIDIME CEFTAZIDIME IN DEXTROSE CONTAINER CEPTAZ FORTAZ PENTACEF TAZICEF TAZIDIME TAZIDIME IN PLASTIC CONTAINER
Synonyms	Ceftazidime Ceftazidime (arginine formulation) Ceftazidime anhydrous Ceftazidime hydrate Ceftazidime pentahydrate Ceptaz Fortam Fortaz Fortum GR 20263 GR-20263 J01DD07 Kefazim LY 139381 LY-139381
Status
Molecule Category	Free-form
ATC	J01DD02
UNII	DZR1ENT301
EPA CompTox	DTXSID5022770


InChI Key	ORFOPKXBNMVMKC-DWVKKRMSSA-N
Smiles	CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O
InChI	InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1

Property Name	Value
Molecular Formula	C22H22N6O7S2
Molecular Weight	546.59
AlogP	-1.3
Hydrogen Bond Acceptor	11.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	9.0
Polar Surface Area	191.22
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	37.0

Mechanism of Action	Action	Reference
Bacterial penicillin-binding protein inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Unclassified protein	-	-	-	-	100

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Escherichia coli	-	-	-	20-140	17-100
Homo sapiens	-	-	-	-	100

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	3508
ChEMBL	CHEMBL44354
DrugBank	DB00438
FDA SRS	DZR1ENT301
Human Metabolome Database	HMDB0014582
Guide to Pharmacology	10762
KEGG	C06889
PharmGKB	PA448861
PubChem	6536864
SureChEMBL	SCHEMBL36849
ZINC	ZINC03871960

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

CEFTAZIDIME

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References