CARGLUMIC ACID

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Search structure


Trade Names	CARBAGLU
Synonyms	Carbaglu Carglumic acid N-carbamyl-l-glutamic acid NSC-760124 OE 312 OE 312 (LABORATORY CODE DESIGNATION) OE-312
Status
Molecule Category	Free-form
ATC	A16AA05
UNII	5L0HB4V1EW
EPA CompTox	DTXSID7046706

Structure


InChI Key	LCQLHJZYVOQKHU-VKHMYHEASA-N
Smiles	NC(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI	InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C6H10N2O5
Molecular Weight	190.16
AlogP	-1.03
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	5.0
Polar Surface Area	129.72
Molecular species	ACID
Aromatic Rings	0.0
Heavy Atoms	13.0

Pharmacology

Mechanism of Action	Action	Reference
Carbamoyl-phosphate synthase [ammonia], mitochondrial positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	DailyMed

Cross References

Resources	Reference
ChEBI	71028
ChEMBL	CHEMBL1201780
DrugBank	DB06775
DrugCentral	3068
FDA SRS	5L0HB4V1EW
Human Metabolome Database	HMDB0015673
Guide to Pharmacology	7458
KEGG	C05829
PharmGKB	PA165958402
PubChem	121396
SureChEMBL	SCHEMBL373546
ZINC	ZINC000001530283

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025