ATROPINE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC A03BA01 S01FA01
UNII 7C0697DR9I
EPA CompTox DTXSID4020113

Structure

InChI Key RKUNBYITZUJHSG-SPUOUPEWSA-N
Smiles CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2
InChI
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H23NO3
Molecular Weight 289.37
AlogP 1.93
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 49.77
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 21.0

Bioactivity

Mechanism of Action Action Reference
Muscarinic acetylcholine receptor M1 antagonist ANTAGONIST Wikipedia FDA ISBN
Protein: Muscarinic acetylcholine receptor M2
Description: Muscarinic acetylcholine receptor M2
Organism : Homo sapiens
P08172 ENSG00000181072
Protein: Muscarinic acetylcholine receptor M1
Description: Muscarinic acetylcholine receptor M1
Organism : Homo sapiens
P11229 ENSG00000168539
Protein: Muscarinic acetylcholine receptor M3
Description: Muscarinic acetylcholine receptor M3
Organism : Homo sapiens
P20309 ENSG00000133019
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - 0-1 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor
- - - 32500 -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 5
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- 1-5 1-2 0-19 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- 12200 - - 77
Assay Description Organism Bioactivity Reference
Tested for antimuscarinic potency on guinea pig heart force Cavia porcellus 1.122 nM
Tested for antimuscarinic potency on guinea pig heart rate Cavia porcellus 0.8913 nM
Tested for antimuscarinic potency on guinea pig ileum Cavia porcellus 1.23 nM
Tested for antimuscarinic potency on rat bladder Rattus norvegicus 1.288 nM
Compound was evaluated for the binding affinity by displacing [3H]methylscopolamine [3H]NMS from mouse cerebral cortex tissue. None 0.7 nM
Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue. None 0.35 nM
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart Rattus norvegicus 7.5 nM
Dissociation constant of the compound-receptor complex. Cavia porcellus 0.9 nM
Anticholinergic activity was determined in vitro by measuring their effect on the acetylcholine chloride induced contraction of guinea pig ileum Cavia porcellus 0.0038 ug.mL-1
Antimuscarinic activity was assayed for its ability to block the acetyl-choline induced contraction of the guinea pig ileum Cavia porcellus 1.995 nM
Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate None 0.76 nM
Ability to displace [3H]N-methylscopolamine (NMS) from M3 receptor in rat submaxillary gland homogenate None 0.12 nM
Ability to displace [3H]pirenzepine (PZ) from M1 receptor in rat cortex homogenate None 0.26 nM
Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypes None 2.4 nM
Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3 Cricetulus griseus 0.329 nM
Antagonism to the H1 receptor of guinea pig ileum was determined Cavia porcellus 0.7762 nM
Displacement of [3H]QNB from rat ileum Muscarinic acetylcholine receptor Rattus norvegicus 0.45 nM
Inhibition of [3H]QNB binding towards muscarinic acetylcholine receptor in guinea pig ileum. Cavia porcellus 0.683 nM
Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileum Cavia porcellus 0.9 nM
Determination of dissociation constant from antimuscarinic activity on isolated guinea pig ileum. Cavia porcellus 0.9 nM
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig. Cavia porcellus 0.32 nM
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig. Cavia porcellus 0.89 nM
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the parotid gland from Guinea Pig. Cavia porcellus 0.85 nM
Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement. Cavia porcellus 1.6 nM
Inhibition of [3H]NMS (N-[3H]methylscopolamine) binding to Muscarinic acetylcholine receptor (mAChR) Cavia porcellus 2.4 nM
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M1 Homo sapiens 0.25 nM
Antagonist activity against Muscarinic acetylcholine receptor of guinea pig heart. Cavia porcellus 1.122 nM Antagonist activity against Muscarinic acetylcholine receptor of guinea pig heart. Cavia porcellus 0.8913 nM
Antagonist activity against Muscarinic acetylcholine receptor of guinea pig ileum Cavia porcellus 1.23 nM
Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria Cavia porcellus 1.349 nM
Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor Cavia porcellus 1.479 nM
Compound was evaluated for blocking activity on Muscarinic acetylcholine receptor in guinea pig atria Cavia porcellus 2.042 nM
muscarinic acetylcholine receptor M1 Cricetulus griseus 0.344 nM
Inhibit the binding of [N-mnethyl-3H]-scopolamine [3H]-NMS) to Muscarinic acetylcholine receptor of human IRM-30 neuroblastoma cells None 1.0 nM
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M3 Homo sapiens 0.5 nM
Concentration of compound for 50% displacement of [3H]QNB from Muscarinic acetylcholine receptor in rat brain None 4.84 nM
In vitro receptor binding against Muscarinic acetylcholine receptor M3 in rat submandibular gland was determined using [3H]pirenzepine Rattus norvegicus 0.63 nM
In vitro receptor binding against Muscarinic acetylcholine receptor M1 in rat cerebral cortex was determined using [3H]pirenzepine Rattus norvegicus 1.3 nM
Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenates Rattus norvegicus 0.26 nM
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M4 Homo sapiens 0.34 nM
Inhibition of [3H]- Oxo-M binding to muscarinic acetylcholine receptor of rat brain membrane preparations None 0.459 nM
Inhibition of [3H]QNB binding to muscarinic acetylcholine receptor of rat heart membrane preparation. None 0.337 nM
The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brain None 0.3 nM
Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat brain. None 0.337 nM
Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranes None 0.459 nM
Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype. Cavia porcellus 1.995 nM
Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5 Homo sapiens 0.54 nM
Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortex None 0.9 nM
Antagonist activity against Muscarinic acetylcholine receptor of rat bladder Rattus norvegicus 1.288 nM
Compound was evaluated for blocking activity on Muscarinic acetylcholine receptor in rat bladder None 1.479 nM
Compound was evaluated for blocking activity on Muscarinic acetylcholine receptor in rat ileum None 1.318 nM
Affinity for the Muscarinic acetylcholine receptor Rattus norvegicus 1.862 nM
Displacement of [3H]- quinuclidinyl benzilate from rat brain Muscarinic acetylcholine receptor Rattus norvegicus 1.3 nM
Inhibition of [3H]QNB binding towards muscarinic acetylcholine receptor in rat brain None 0.834 nM
Inhibition of [3H]QNB binding towards muscarinic acetylcholine receptor in rat heart None 0.371 nM
Inhibition of [3H]pirenzepine binding towards muscarinic acetylcholine receptor in rat brain. None 0.545 nM
Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2 Homo sapiens 1.5 nM
Binding affinity towards muscarinic m1 receptor None 2.0 nM
Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex Mus musculus 0.7 nM
Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex Mus musculus 0.35 nM
Binding affinity towards muscarinic m2 receptor None 1.0 nM
Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum Bos taurus 0.2 nM
In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine Rattus norvegicus 2.7 nM
Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium Rattus norvegicus 0.7 nM
Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates Rattus norvegicus 0.76 nM
Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes None 1.6 nM
Inhibition of carbachol-induced release of alpha-amylase from pancreatic acini from rat was determined Rattus norvegicus 51.0 nM
Antispasmodic activity was measured as percent reduction in rat ileum contraction against 300 ug/mL barium chloride 0.5 ug/mL (1.5 X 10E-6 uM) Rattus norvegicus 5.9 %
Evaluated for the phosphatidyl inositol turnover at Muscarinic acetylcholine receptor M1 in rat cortex Rattus norvegicus 0.5 nM
Antispasmodic activity calculated as ability of compound to block ACh-induced contractions of the ileum and expressed as pA2 Rattus norvegicus 1.862 nM
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM Cavia porcellus 4.5 %
Inhibition of acetylcholine-induced contraction in guinea pig ileum preincubated for 5 mins before acetylcholine challenge Cavia porcellus 2.042 nM
Inhibition of COX2 at 100 uM by scintillation proximity assay None 30.0 %
Displacement of [3H]pirenzepine from muscarinic M1 receptor None 0.3 nM
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as increase in acetylcholine potency at 30 uM by calcium mobilization-based ACh concentration-response curve assay relative to control Homo sapiens 0.21 nM
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy Homo sapiens 76.5 %
Antagonist activity at muscarinic receptor None 0.4571 nM
Inhibition of [3H]NMS binding to muscarinic receptor in mouse N4TG1 neuroblastoma cells Mus musculus 3.981 nM
Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting Rattus norvegicus 0.52 nM Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting Rattus norvegicus 0.52 nM
Displacement of [3H]NMS from rat recombinant muscarinic M1 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting Rattus norvegicus 0.79 nM
Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting Rattus norvegicus 1.45 nM
Displacement of [3H]NMS from rat recombinant muscarinic M3 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting Rattus norvegicus 0.8 nM
Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting Rattus norvegicus 0.86 nM
Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells Homo sapiens 1.9 nM
Displacement of [3H]-4-DAMP from human muscarinic M3 receptor expressed in BHK-21 cells Homo sapiens 0.9 nM
Displacement of [3H]-4-DAMP from human muscarinic M4 receptor expressed in BHK-21 cells Homo sapiens 3.0 nM
Displacement of [3H]-4-DAMP from human muscarinic M5 receptor expressed in BHK-21 cells Homo sapiens 1.0 nM
Inhibition of rat muscarinic M receptor Rattus norvegicus 0.48 nM
Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation counting None 0.4 nM
DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) None 1.521 nM DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) None 0.366 nM
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) None 3.735 nM DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) None 1.328 nM
DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) None 2.071 nM DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) None 0.439 nM
DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) None 0.744 nM DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) None 0.104 nM
DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) None 0.922 nM DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) None 0.662 nM
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) None 666.0 nM
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) None 530.0 nM
Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42 Homo sapiens 1.202 nM
Displacement of [3H]NMS from EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 22 hrs by liquid scintillation counting Homo sapiens 0.5754 nM
Antiamoebic activity against Entamoeba histolytica Entamoeba histolytica 100.0 ug.mL-1
Ionotropic activity in Cavia porcellus (guinea pig) ileum assessed as inhibition of acetylcholine-induced contraction after 15 min by physiographic analysis Cavia porcellus 3.981 nM
Displacement of [3H]NMS from rat muscarinic M1 receptor expressed in CHO cells after 3 hrs Rattus norvegicus 1.38 nM Displacement of [3H]NMS from rat muscarinic M1 receptor expressed in CHO cells after 3 hrs Rattus norvegicus 1.4 nM
Displacement of [3H] N-methylscopolamine from human muscarinic M4 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis Homo sapiens 1.39 nM
Displacement of [3H] N-methylscopolamine from human muscarinic M3 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis Homo sapiens 2.18 nM
Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis Homo sapiens 1.44 nM
Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis Homo sapiens 0.922 nM
Displacement of [3H] N-methylscopolamine from muscarinic acetylcholine receptor in guinea pig brain homogenate after 30 mins by scintillation counting analysis Cavia porcellus 2.49 nM
Inhibition of muscarinic acetylcholine receptor in rat cortex Rattus norvegicus 0.12 nM
Displacement of [3H]NMS from human muscarinic acetylcholine receptor subtype 5 expressed in CHO cell membranes by scintillation counting method Homo sapiens 1.47 nM
Displacement of [3H]-quinuclydinyl benzylate from muscarinic receptor (unknown origin) Homo sapiens 470.0 nM
Displacement of [3H]-NMS from recombinant human M4 receptor expressed in CHO cell membranes Homo sapiens 1.6 nM
Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay Homo sapiens 0.8128 nM
Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay Homo sapiens 16.98 nM
Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells Homo sapiens 15.85 nM
Displacement of [3H]NMS from human recombinant muscarinic M4 receptor expressed in CHO cell membranes Homo sapiens 0.64 nM
Antagonist potency at muscarinic M3 receptor in guinea-pig ileum assessed as inhibition of carbachol-induced contractions after 15 mins Cavia porcellus 1.023 nM
Antagonist activity at muscarinic receptor in guinea pig ileum assessed as carbachol-induced ileum contraction measured after 15 mins Cavia porcellus 1.035 nM
Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method Homo sapiens 0.44 nM
Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method Homo sapiens 0.9 nM
Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method Homo sapiens 0.53 nM
Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method Homo sapiens 0.6 nM
Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay Homo sapiens 8.128 nM
Antagonist activity at muscarinic M3 receptor in guinea-pig ileum assessed as inhibition of carbachol-induced contractions after 15 mins Cavia porcellus 1.023 nM
Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay Homo sapiens 8.128 nM
Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry Homo sapiens 2.512 nM
Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay Homo sapiens 18.62 nM
Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay Homo sapiens 4.898 nM
Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay Homo sapiens 3.162 nM
Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay Homo sapiens 7.079 nM
Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay Homo sapiens 0.912 nM
Myorelaxant effect in Sprague-Dawley rat tracheal ring assessed as maximal relaxation of carbachol-induced smooth muscle contraction by organ bath assay Rattus norvegicus 0.98 nM

Related Entries

Cross References

Resources Reference
ChEBI 78734
ChEMBL CHEMBL517712
DrugBank DB00572
DrugCentral 260
FDA SRS 7C0697DR9I
Human Metabolome Database HMDB0014712
Guide to Pharmacology 320
KEGG C01479
SureChEMBL SCHEMBL2812
CONTENTS