AMINOCAPROIC ACID


Trade Names	AMICAR AMINOCAPROIC AMINOCAPROIC ACID AMINOCAPROIC ACID IN PLASTIC CONTAINER
Synonyms	.epsilon.-aminocaproic acid 177 J.D 177 J.D. 177 JD 177-JD 6-aminocaproic acid Amicar Aminocaproic Aminocaproic acid CL 10304 CL-10304 CY-116 EACA Epsikapron Epsilcapramin Epsilon-aminocaproic acid Hexanoic acid, 6-amino- NSC-26154 NSC-400230
Status
Molecule Category	UNKNOWN
ATC	B02AA01
UNII	U6F3787206
EPA CompTox	DTXSID0020070


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	SLXKOJJOQWFEFD-UHFFFAOYSA-N
Smiles	NCCCCCC(=O)O
InChI	InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

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Mechanism of Action	Action	Reference
Plasminogen inhibitor	INHIBITOR	DailyMed


Protein: Plasminogen Description: Plasminogen Organism : Homo sapiens P00747 ENSG00000122194











Protein: Tissue-type plasminogen activator Description: Tissue-type plasminogen activator Organism : Homo sapiens P00750 ENSG00000104368

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	-	40000	9000	-	-

Assay Description	Organism	Bioactivity
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	-7.52 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	7.08 %	SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	13.2 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.04 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.01 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.04 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.01 %

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