Gene: P2RX7
Ensembl ID : ENSG00000089041
Description: purinergic receptor P2X 7
Gene Synonyms: MGC20089,P2X7
4 APIs:
195 Possible Orthologues:

Purinergic signaling in leishmaniasis infection R-HSA-9660826
Infectious disease R-HSA-5663205
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Hemostasis R-HSA-109582
Inflammasomes R-HSA-622312
Immune System R-HSA-168256
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Elevation of cytosolic Ca2+ levels R-HSA-139853
Platelet homeostasis R-HSA-418346
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Innate Immune System R-HSA-168249
The NLRP3 inflammasome R-HSA-844456
Platelet calcium homeostasis R-HSA-418360
The NLRP3 inflammasome R-HSA-844456
Immune System R-HSA-168256
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Hemostasis R-HSA-109582
Platelet calcium homeostasis R-HSA-418360
Inflammasomes R-HSA-622312
Leishmania infection R-HSA-9658195
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Elevation of cytosolic Ca2+ levels R-HSA-139853
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Platelet homeostasis R-HSA-418346
Disease R-HSA-1643685
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet homeostasis R-HSA-418346
Immune System R-HSA-168256
Platelet calcium homeostasis R-HSA-418360
Cell recruitment (pro-inflammatory response) R-HSA-9664424
The NLRP3 inflammasome R-HSA-844456
Inflammasomes R-HSA-622312
Hemostasis R-HSA-109582
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Disease R-HSA-1643685
Elevation of cytosolic Ca2+ levels R-HSA-139853
Infectious disease R-HSA-5663205
Leishmania infection R-HSA-9658195
Innate Immune System R-HSA-168249
Elevation of cytosolic Ca2+ levels R-HSA-139853
Hemostasis R-HSA-109582
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Platelet homeostasis R-HSA-418346
Inflammasomes R-HSA-622312
The NLRP3 inflammasome R-HSA-844456
Infectious disease R-HSA-5663205
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Platelet calcium homeostasis R-HSA-418360
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Disease R-HSA-1643685
Immune System R-HSA-168256
Platelet calcium homeostasis R-HSA-418360
Infectious disease R-HSA-5663205
Elevation of cytosolic Ca2+ levels R-HSA-139853
Innate Immune System R-HSA-168249
Inflammasomes R-HSA-622312
Platelet homeostasis R-HSA-418346
The NLRP3 inflammasome R-HSA-844456
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Hemostasis R-HSA-109582
Leishmania infection R-HSA-9658195
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Inflammasomes R-HSA-622312
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Immune System R-HSA-168256
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Disease R-HSA-1643685
Elevation of cytosolic Ca2+ levels R-HSA-139853
Hemostasis R-HSA-109582
Platelet homeostasis R-HSA-418346
Purinergic signaling in leishmaniasis infection R-HSA-9660826
The NLRP3 inflammasome R-HSA-844456
Leishmania infection R-HSA-9658195
Platelet calcium homeostasis R-HSA-418360
Infectious disease R-HSA-5663205
Innate Immune System R-HSA-168249
Disease R-HSA-1643685
Inflammasomes R-HSA-622312
Immune System R-HSA-168256
Elevation of cytosolic Ca2+ levels R-HSA-139853
Innate Immune System R-HSA-168249
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Hemostasis R-HSA-109582
Leishmania infection R-HSA-9658195
Infectious disease R-HSA-5663205
The NLRP3 inflammasome R-HSA-844456
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Platelet homeostasis R-HSA-418346
Platelet calcium homeostasis R-HSA-418360
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Elevation of cytosolic Ca2+ levels R-HSA-139853
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Leishmania infection R-HSA-9658195
Infectious disease R-HSA-5663205
Innate Immune System R-HSA-168249
Inflammasomes R-HSA-622312
Disease R-HSA-1643685
Platelet calcium homeostasis R-HSA-418360
Platelet homeostasis R-HSA-418346
Immune System R-HSA-168256
Hemostasis R-HSA-109582
The NLRP3 inflammasome R-HSA-844456
Innate Immune System R-HSA-168249
Platelet calcium homeostasis R-HSA-418360
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Infectious disease R-HSA-5663205
Elevation of cytosolic Ca2+ levels R-HSA-139853
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Hemostasis R-HSA-109582
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Immune System R-HSA-168256
Inflammasomes R-HSA-622312
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Platelet homeostasis R-HSA-418346
The NLRP3 inflammasome R-HSA-844456
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Elevation of cytosolic Ca2+ levels R-HSA-139853
Platelet homeostasis R-HSA-418346
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet calcium homeostasis R-HSA-418360
Leishmania infection R-HSA-9658195
Inflammasomes R-HSA-622312
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Hemostasis R-HSA-109582
Disease R-HSA-1643685
The NLRP3 inflammasome R-HSA-844456
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Infectious disease R-HSA-5663205

Expression Atlas ENSG00000089041
NCBI gene (formerly Entrezgene) 5027
GeneCards 8537
HGNC Symbol HGNC:8537
MIM gene 602566
UniProtKB Gene Name Q99572
WikiGene 5027
Gene: ADA
Ensembl ID : ENSG00000196839
Description: adenosine deaminase
Gene Synonyms: ADA1
2 APIs:
219 Possible Orthologues:

Metabolism R-HSA-1430728
Nucleotide salvage defects R-HSA-9734207
Ribavirin ADME R-HSA-9755088
Drug ADME R-HSA-9748784
Nucleotide salvage R-HSA-8956321
Diseases of metabolism R-HSA-5668914
Diseases of nucleotide metabolism R-HSA-9735804
Disease R-HSA-1643685
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Metabolism of nucleotides R-HSA-15869
Purine salvage R-HSA-74217
Diseases of nucleotide metabolism R-HSA-9735804
Drug ADME R-HSA-9748784
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Metabolism of nucleotides R-HSA-15869
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Nucleotide salvage R-HSA-8956321
Nucleotide salvage defects R-HSA-9734207
Ribavirin ADME R-HSA-9755088
Diseases of metabolism R-HSA-5668914
Purine salvage R-HSA-74217
Metabolism of nucleotides R-HSA-15869
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Purine salvage R-HSA-74217
Drug ADME R-HSA-9748784
Nucleotide salvage R-HSA-8956321
Nucleotide salvage defects R-HSA-9734207
Metabolism R-HSA-1430728
Diseases of nucleotide metabolism R-HSA-9735804
Diseases of metabolism R-HSA-5668914
Ribavirin ADME R-HSA-9755088
Disease R-HSA-1643685
Disease R-HSA-1643685
Ribavirin ADME R-HSA-9755088
Metabolism of nucleotides R-HSA-15869
Diseases of metabolism R-HSA-5668914
Nucleotide salvage R-HSA-8956321
Drug ADME R-HSA-9748784
Nucleotide salvage defects R-HSA-9734207
Diseases of nucleotide metabolism R-HSA-9735804
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Metabolism R-HSA-1430728
Purine salvage R-HSA-74217
Metabolism of nucleotides R-HSA-15869
Metabolism R-HSA-1430728
Diseases of nucleotide metabolism R-HSA-9735804
Disease R-HSA-1643685
Purine salvage R-HSA-74217
Ribavirin ADME R-HSA-9755088
Drug ADME R-HSA-9748784
Diseases of metabolism R-HSA-5668914
Nucleotide salvage R-HSA-8956321
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Nucleotide salvage defects R-HSA-9734207
Drug ADME R-HSA-9748784
Nucleotide salvage defects R-HSA-9734207
Metabolism R-HSA-1430728
Diseases of nucleotide metabolism R-HSA-9735804
Metabolism of nucleotides R-HSA-15869
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Disease R-HSA-1643685
Diseases of metabolism R-HSA-5668914
Ribavirin ADME R-HSA-9755088
Nucleotide salvage R-HSA-8956321
Purine salvage R-HSA-74217
Nucleotide salvage R-HSA-8956321
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Metabolism of nucleotides R-HSA-15869
Drug ADME R-HSA-9748784
Purine salvage R-HSA-74217
Nucleotide salvage defects R-HSA-9734207
Diseases of nucleotide metabolism R-HSA-9735804
Disease R-HSA-1643685
Metabolism R-HSA-1430728
Ribavirin ADME R-HSA-9755088
Diseases of metabolism R-HSA-5668914
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Metabolism R-HSA-1430728
Nucleotide salvage R-HSA-8956321
Diseases of nucleotide metabolism R-HSA-9735804
Drug ADME R-HSA-9748784
Metabolism of nucleotides R-HSA-15869
Ribavirin ADME R-HSA-9755088
Diseases of metabolism R-HSA-5668914
Disease R-HSA-1643685
Purine salvage R-HSA-74217
Nucleotide salvage defects R-HSA-9734207
Nucleotide salvage R-HSA-8956321
Ribavirin ADME R-HSA-9755088
Diseases of nucleotide metabolism R-HSA-9735804
Disease R-HSA-1643685
Drug ADME R-HSA-9748784
Metabolism of nucleotides R-HSA-15869
Diseases of metabolism R-HSA-5668914
Metabolism R-HSA-1430728
Purine salvage R-HSA-74217
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Nucleotide salvage defects R-HSA-9734207
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735
Metabolism of nucleotides R-HSA-15869
Metabolism R-HSA-1430728
Diseases of metabolism R-HSA-5668914
Disease R-HSA-1643685
Diseases of nucleotide metabolism R-HSA-9735804
Nucleotide salvage defects R-HSA-9734207
Nucleotide salvage R-HSA-8956321
Drug ADME R-HSA-9748784
Purine salvage R-HSA-74217
Ribavirin ADME R-HSA-9755088
Nucleotide salvage defects R-HSA-9734207
Disease R-HSA-1643685
Metabolism R-HSA-1430728
Ribavirin ADME R-HSA-9755088
Metabolism of nucleotides R-HSA-15869
Nucleotide salvage R-HSA-8956321
Drug ADME R-HSA-9748784
Purine salvage R-HSA-74217
Diseases of metabolism R-HSA-5668914
Diseases of nucleotide metabolism R-HSA-9735804
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735

Expression Atlas ENSG00000196839
DataBase of Aberrant 3' Splice Sites
LRG display in Ensembl gene LRG_16
NCBI gene (formerly Entrezgene) 100
GeneCards 186
HGNC Symbol HGNC:186
MIM gene 608958
MIM morbid 102700
UniProtKB Gene Name P00813
WikiGene 100
Gene: GRM2
Ensembl ID : ENSG00000164082
Description: glutamate metabotropic receptor 2
Gene Synonyms: GPRC1B,MGLU2,MGLUR2
6 APIs:
281 Possible Orthologues:

G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
G alpha (i) signalling events R-HSA-418594
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594

Expression Atlas ENSG00000164082
NCBI gene (formerly Entrezgene) 2912
GeneCards 4594
HGNC Symbol HGNC:4594
MIM gene 604099
UniProtKB Gene Name Q14416
WikiGene 2912
Gene: RPL4
Ensembl ID : ENSG00000174444
Description: ribosomal protein L4
Gene Synonyms: L4
4 APIs:
263 Possible Orthologues:

Nonsense-Mediated Decay (NMD) R-HSA-927802
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Metabolism of proteins R-HSA-392499
Eukaryotic Translation Elongation R-HSA-156842
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Translation R-HSA-72766
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Metabolism of amino acids and derivatives R-HSA-71291
Axon guidance R-HSA-422475
rRNA processing R-HSA-72312
Peptide chain elongation R-HSA-156902
Viral mRNA Translation R-HSA-192823
Influenza Viral RNA Transcription and Replication R-HSA-168273
Eukaryotic Translation Termination R-HSA-72764
Cap-dependent Translation Initiation R-HSA-72737
Infectious disease R-HSA-5663205
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Formation of a pool of free 40S subunits R-HSA-72689
Disease R-HSA-1643685
Metabolism R-HSA-1430728
Selenocysteine synthesis R-HSA-2408557
Influenza Infection R-HSA-168255
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
rRNA processing in the nucleus and cytosol R-HSA-8868773
Nervous system development R-HSA-9675108
Metabolism of RNA R-HSA-8953854
Eukaryotic Translation Initiation R-HSA-72613
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Cellular response to starvation R-HSA-9711097
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Selenoamino acid metabolism R-HSA-2408522
Cellular responses to stress R-HSA-2262752
Eukaryotic Translation Termination R-HSA-72764
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Cap-dependent Translation Initiation R-HSA-72737
Disease R-HSA-1643685
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Eukaryotic Translation Initiation R-HSA-72613
Cellular response to starvation R-HSA-9711097
Peptide chain elongation R-HSA-156902
Metabolism of amino acids and derivatives R-HSA-71291
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Cellular responses to stimuli R-HSA-8953897
Signaling by ROBO receptors R-HSA-376176
Translation R-HSA-72766
Eukaryotic Translation Elongation R-HSA-156842
Axon guidance R-HSA-422475
rRNA processing in the nucleus and cytosol R-HSA-8868773
rRNA processing R-HSA-72312
Infectious disease R-HSA-5663205
Influenza Viral RNA Transcription and Replication R-HSA-168273
Selenoamino acid metabolism R-HSA-2408522
Selenocysteine synthesis R-HSA-2408557
Developmental Biology R-HSA-1266738
Metabolism R-HSA-1430728
Nonsense-Mediated Decay (NMD) R-HSA-927802
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Formation of a pool of free 40S subunits R-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Metabolism of proteins R-HSA-392499
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Influenza Infection R-HSA-168255
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Metabolism of RNA R-HSA-8953854
Nervous system development R-HSA-9675108
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Viral mRNA Translation R-HSA-192823
Cellular responses to stress R-HSA-2262752
Developmental Biology R-HSA-1266738
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
rRNA processing in the nucleus and cytosol R-HSA-8868773
Disease R-HSA-1643685
Signaling by ROBO receptors R-HSA-376176
Influenza Viral RNA Transcription and Replication R-HSA-168273
Nonsense-Mediated Decay (NMD) R-HSA-927802
Metabolism of RNA R-HSA-8953854
Translation R-HSA-72766
Cap-dependent Translation Initiation R-HSA-72737
Influenza Infection R-HSA-168255
Peptide chain elongation R-HSA-156902
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Eukaryotic Translation Initiation R-HSA-72613
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Cellular responses to stimuli R-HSA-8953897
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Eukaryotic Translation Termination R-HSA-72764
Metabolism of proteins R-HSA-392499
Viral mRNA Translation R-HSA-192823
Infectious disease R-HSA-5663205
Eukaryotic Translation Elongation R-HSA-156842
Axon guidance R-HSA-422475
Selenoamino acid metabolism R-HSA-2408522
Metabolism of amino acids and derivatives R-HSA-71291
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Cellular response to starvation R-HSA-9711097
Metabolism R-HSA-1430728
Formation of a pool of free 40S subunits R-HSA-72689
Selenocysteine synthesis R-HSA-2408557
rRNA processing R-HSA-72312
Nervous system development R-HSA-9675108
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
rRNA processing in the nucleus and cytosol R-HSA-8868773
Viral mRNA Translation R-HSA-192823
Metabolism of proteins R-HSA-392499
Formation of a pool of free 40S subunits R-HSA-72689
Metabolism of RNA R-HSA-8953854
Developmental Biology R-HSA-1266738
Infectious disease R-HSA-5663205
Influenza Infection R-HSA-168255
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Metabolism R-HSA-1430728
Translation R-HSA-72766
Eukaryotic Translation Elongation R-HSA-156842
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Selenoamino acid metabolism R-HSA-2408522
Metabolism of amino acids and derivatives R-HSA-71291
Signaling by ROBO receptors R-HSA-376176
Eukaryotic Translation Initiation R-HSA-72613
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Nervous system development R-HSA-9675108
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Disease R-HSA-1643685
Nonsense-Mediated Decay (NMD) R-HSA-927802
Influenza Viral RNA Transcription and Replication R-HSA-168273
Axon guidance R-HSA-422475
Eukaryotic Translation Termination R-HSA-72764
Selenocysteine synthesis R-HSA-2408557
Cellular responses to stimuli R-HSA-8953897
Cap-dependent Translation Initiation R-HSA-72737
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Peptide chain elongation R-HSA-156902
Cellular response to starvation R-HSA-9711097
Cellular responses to stress R-HSA-2262752
rRNA processing R-HSA-72312
Formation of a pool of free 40S subunits R-HSA-72689
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Eukaryotic Translation Initiation R-HSA-72613
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Cellular responses to stress R-HSA-2262752
Metabolism of RNA R-HSA-8953854
Metabolism of amino acids and derivatives R-HSA-71291
Axon guidance R-HSA-422475
rRNA processing R-HSA-72312
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Disease R-HSA-1643685
Metabolism R-HSA-1430728
Infectious disease R-HSA-5663205
Developmental Biology R-HSA-1266738
Selenoamino acid metabolism R-HSA-2408522
Influenza Infection R-HSA-168255
Peptide chain elongation R-HSA-156902
Cellular responses to stimuli R-HSA-8953897
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Translation R-HSA-72766
Eukaryotic Translation Elongation R-HSA-156842
Signaling by ROBO receptors R-HSA-376176
Influenza Viral RNA Transcription and Replication R-HSA-168273
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Cellular response to starvation R-HSA-9711097
Eukaryotic Translation Termination R-HSA-72764
Selenocysteine synthesis R-HSA-2408557
Viral mRNA Translation R-HSA-192823
Cap-dependent Translation Initiation R-HSA-72737
rRNA processing in the nucleus and cytosol R-HSA-8868773
Nonsense-Mediated Decay (NMD) R-HSA-927802
Nervous system development R-HSA-9675108
Metabolism of proteins R-HSA-392499
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Formation of a pool of free 40S subunits R-HSA-72689
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Metabolism of RNA R-HSA-8953854
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Translation R-HSA-72766
Signaling by ROBO receptors R-HSA-376176
Eukaryotic Translation Elongation R-HSA-156842
Nonsense-Mediated Decay (NMD) R-HSA-927802
Infectious disease R-HSA-5663205
Selenoamino acid metabolism R-HSA-2408522
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Influenza Infection R-HSA-168255
Axon guidance R-HSA-422475
rRNA processing R-HSA-72312
Disease R-HSA-1643685
Nervous system development R-HSA-9675108
Cap-dependent Translation Initiation R-HSA-72737
Viral mRNA Translation R-HSA-192823
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
rRNA processing in the nucleus and cytosol R-HSA-8868773
Cellular responses to stimuli R-HSA-8953897
Cellular response to starvation R-HSA-9711097
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Metabolism of proteins R-HSA-392499
Developmental Biology R-HSA-1266738
Cellular responses to stress R-HSA-2262752
Influenza Viral RNA Transcription and Replication R-HSA-168273
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Eukaryotic Translation Initiation R-HSA-72613
Peptide chain elongation R-HSA-156902
Eukaryotic Translation Termination R-HSA-72764
Metabolism of amino acids and derivatives R-HSA-71291
Metabolism R-HSA-1430728
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Selenocysteine synthesis R-HSA-2408557
Metabolism of RNA R-HSA-8953854
Signaling by ROBO receptors R-HSA-376176
rRNA processing R-HSA-72312
Viral mRNA Translation R-HSA-192823
Metabolism of proteins R-HSA-392499
rRNA processing in the nucleus and cytosol R-HSA-8868773
Metabolism of amino acids and derivatives R-HSA-71291
Cellular response to starvation R-HSA-9711097
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Influenza Viral RNA Transcription and Replication R-HSA-168273
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Translation R-HSA-72766
Eukaryotic Translation Termination R-HSA-72764
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Cellular responses to stress R-HSA-2262752
Eukaryotic Translation Elongation R-HSA-156842
Cellular responses to stimuli R-HSA-8953897
Nonsense-Mediated Decay (NMD) R-HSA-927802
Metabolism R-HSA-1430728
Selenoamino acid metabolism R-HSA-2408522
Selenocysteine synthesis R-HSA-2408557
Nervous system development R-HSA-9675108
Cap-dependent Translation Initiation R-HSA-72737
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Developmental Biology R-HSA-1266738
Eukaryotic Translation Initiation R-HSA-72613
Formation of a pool of free 40S subunits R-HSA-72689
Peptide chain elongation R-HSA-156902
Influenza Infection R-HSA-168255
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Infectious disease R-HSA-5663205
Influenza Viral RNA Transcription and Replication R-HSA-168273
Nervous system development R-HSA-9675108
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Eukaryotic Translation Initiation R-HSA-72613
Signaling by ROBO receptors R-HSA-376176
rRNA processing R-HSA-72312
rRNA processing in the nucleus and cytosol R-HSA-8868773
Peptide chain elongation R-HSA-156902
Metabolism of proteins R-HSA-392499
Selenocysteine synthesis R-HSA-2408557
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Metabolism of RNA R-HSA-8953854
Cellular responses to stimuli R-HSA-8953897
Cap-dependent Translation Initiation R-HSA-72737
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Nonsense-Mediated Decay (NMD) R-HSA-927802
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Metabolism R-HSA-1430728
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Cellular response to starvation R-HSA-9711097
Axon guidance R-HSA-422475
Influenza Infection R-HSA-168255
Eukaryotic Translation Termination R-HSA-72764
Formation of a pool of free 40S subunits R-HSA-72689
Viral mRNA Translation R-HSA-192823
Eukaryotic Translation Elongation R-HSA-156842
Translation R-HSA-72766
Metabolism of amino acids and derivatives R-HSA-71291
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Cellular responses to stress R-HSA-2262752
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Developmental Biology R-HSA-1266738
Selenoamino acid metabolism R-HSA-2408522
Cellular responses to stimuli R-HSA-8953897
Translation R-HSA-72766
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Selenocysteine synthesis R-HSA-2408557
Eukaryotic Translation Initiation R-HSA-72613
Nonsense-Mediated Decay (NMD) R-HSA-927802
Cellular response to starvation R-HSA-9711097
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Formation of a pool of free 40S subunits R-HSA-72689
Selenoamino acid metabolism R-HSA-2408522
Influenza Infection R-HSA-168255
Peptide chain elongation R-HSA-156902
rRNA processing in the nucleus and cytosol R-HSA-8868773
Signaling by ROBO receptors R-HSA-376176
Cap-dependent Translation Initiation R-HSA-72737
rRNA processing R-HSA-72312
Influenza Viral RNA Transcription and Replication R-HSA-168273
Viral mRNA Translation R-HSA-192823
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Eukaryotic Translation Termination R-HSA-72764
Nervous system development R-HSA-9675108
Metabolism R-HSA-1430728
Axon guidance R-HSA-422475
Eukaryotic Translation Elongation R-HSA-156842
Infectious disease R-HSA-5663205
Metabolism of proteins R-HSA-392499
Developmental Biology R-HSA-1266738
Metabolism of RNA R-HSA-8953854
Cellular responses to stress R-HSA-2262752
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Metabolism of amino acids and derivatives R-HSA-71291
Regulation of expression of SLITs and ROBOs R-HSA-9010553
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Disease R-HSA-1643685
Signaling by ROBO receptors R-HSA-376176
Metabolism of proteins R-HSA-392499
Formation of a pool of free 40S subunits R-HSA-72689
Peptide chain elongation R-HSA-156902
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226
Selenoamino acid metabolism R-HSA-2408522
Eukaryotic Translation Initiation R-HSA-72613
Metabolism of amino acids and derivatives R-HSA-71291
Developmental Biology R-HSA-1266738
Eukaryotic Translation Elongation R-HSA-156842
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957
Influenza Infection R-HSA-168255
Metabolism of RNA R-HSA-8953854
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Nervous system development R-HSA-9675108
Cellular response to starvation R-HSA-9711097
rRNA processing in the nucleus and cytosol R-HSA-8868773
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Influenza Viral RNA Transcription and Replication R-HSA-168273
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956
Cellular responses to stimuli R-HSA-8953897
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012
Viral mRNA Translation R-HSA-192823
rRNA processing R-HSA-72312
Selenocysteine synthesis R-HSA-2408557
Infectious disease R-HSA-5663205
Cellular responses to stress R-HSA-2262752
Nonsense-Mediated Decay (NMD) R-HSA-927802
Eukaryotic Translation Termination R-HSA-72764
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339
Metabolism R-HSA-1430728
Cap-dependent Translation Initiation R-HSA-72737
Translation R-HSA-72766

Expression Atlas ENSG00000174444
NCBI gene (formerly Entrezgene) 6124
GeneCards 10353
HGNC Symbol HGNC:10353
MIM gene 180479
UniProtKB Gene Name P36578
WikiGene 6124
Gene: ARAF
Ensembl ID : ENSG00000078061
Description: A-Raf proto-oncogene, serine/threonine kinase
Gene Synonyms: ARAF1
1 APIs:
192 Possible Orthologues:

Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Oncogenic MAPK signaling R-HSA-6802957
Signaling by MRAS-complex mutants R-HSA-9660537
Signal Transduction R-HSA-162582
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Disease R-HSA-1643685
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by RAF1 mutants R-HSA-9656223
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF activation R-HSA-5673000
RAF/MAP kinase cascade R-HSA-5673001
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative regulation of MAPK pathway R-HSA-5675221
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by RAS mutants R-HSA-6802949
MAPK family signaling cascades R-HSA-5683057
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAP2K and MAPK activation R-HSA-5674135
Signaling by RAS mutants R-HSA-6802949
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling downstream of RAS mutants R-HSA-9649948
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
RAF activation R-HSA-5673000
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAP2K and MAPK activation R-HSA-5674135
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Disease R-HSA-1643685
Signaling by RAS mutants R-HSA-6802949
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAF1 mutants R-HSA-9656223
Signaling by MRAS-complex mutants R-HSA-9660537
Negative regulation of MAPK pathway R-HSA-5675221
MAP2K and MAPK activation R-HSA-5674135
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Oncogenic MAPK signaling R-HSA-6802957
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by RAF1 mutants R-HSA-9656223
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of MAPK pathway R-HSA-5675221
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAP2K and MAPK activation R-HSA-5674135
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Oncogenic MAPK signaling R-HSA-6802957
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signal Transduction R-HSA-162582
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Oncogenic MAPK signaling R-HSA-6802957
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by MRAS-complex mutants R-HSA-9660537
MAPK family signaling cascades R-HSA-5683057
Signaling by RAF1 mutants R-HSA-9656223
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MRAS-complex mutants R-HSA-9660537
Oncogenic MAPK signaling R-HSA-6802957
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAS mutants R-HSA-6802949
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
RAF/MAP kinase cascade R-HSA-5673001
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling downstream of RAS mutants R-HSA-9649948
RAF activation R-HSA-5673000
Negative regulation of MAPK pathway R-HSA-5675221
MAPK family signaling cascades R-HSA-5683057
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF activation R-HSA-5673000
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAP2K and MAPK activation R-HSA-5674135
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
RAF/MAP kinase cascade R-HSA-5673001
MAP2K and MAPK activation R-HSA-5674135
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF activation R-HSA-5673000
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAF1 mutants R-HSA-9656223
Signal Transduction R-HSA-162582
Signaling by RAS mutants R-HSA-6802949
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of MAPK pathway R-HSA-5675221
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signal Transduction R-HSA-162582
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by RAF1 mutants R-HSA-9656223
RAF activation R-HSA-5673000
MAPK1/MAPK3 signaling R-HSA-5684996
MAP2K and MAPK activation R-HSA-5674135
Signaling by RAS mutants R-HSA-6802949
RAF/MAP kinase cascade R-HSA-5673001
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAS mutants R-HSA-6802949
Negative regulation of MAPK pathway R-HSA-5675221
RAF activation R-HSA-5673000
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948

Expression Atlas ENSG00000078061
NCBI gene (formerly Entrezgene) 369
GeneCards 646
HGNC Symbol HGNC:646
MIM gene 311010
UniProtKB Gene Name P10398
WikiGene 369
Gene: GRM4
Ensembl ID : ENSG00000124493
Description: glutamate metabotropic receptor 4
Gene Synonyms: GPRC1D,MGLU4,MGLUR4
1 APIs:
266 Possible Orthologues:

GPCR downstream signalling R-HSA-388396
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Sensory Perception R-HSA-9709957
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Sensory perception of taste R-HSA-9717189
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
G alpha (i) signalling events R-HSA-418594
Sensory perception of taste R-HSA-9717189
Sensory Perception R-HSA-9709957
Signaling by GPCR R-HSA-372790
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signal Transduction R-HSA-162582
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
GPCR downstream signalling R-HSA-388396
Sensory perception of taste R-HSA-9717189
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Signaling by GPCR R-HSA-372790
Sensory Perception R-HSA-9709957
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Sensory perception of taste R-HSA-9717189
Sensory Perception R-HSA-9709957
G alpha (i) signalling events R-HSA-418594
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Sensory perception of taste R-HSA-9717189
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
GPCR ligand binding R-HSA-500792
Sensory Perception R-HSA-9709957
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
Sensory Perception R-HSA-9709957
Sensory perception of taste R-HSA-9717189
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
Sensory Perception R-HSA-9709957
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Sensory perception of taste R-HSA-9717189
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Sensory perception of taste R-HSA-9717189
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Sensory Perception R-HSA-9709957
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
G alpha (i) signalling events R-HSA-418594
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
GPCR downstream signalling R-HSA-388396
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Sensory perception of taste R-HSA-9717189
GPCR ligand binding R-HSA-500792
Sensory Perception R-HSA-9709957
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
GPCR downstream signalling R-HSA-388396
G alpha (i) signalling events R-HSA-418594
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207
Sensory perception of taste R-HSA-9717189
Signaling by GPCR R-HSA-372790
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499
Sensory Perception R-HSA-9709957

Expression Atlas ENSG00000124493
NCBI gene (formerly Entrezgene) 2914
GeneCards 4596
HGNC Symbol HGNC:4596
MIM gene 604100
UniProtKB Gene Name V9GYR3
WikiGene 2914
Gene: PTPN11
Ensembl ID : ENSG00000179295
Description: protein tyrosine phosphatase non-receptor type 11
Gene Synonyms: BPTP3,NS1,PTP2C,SH-PTP2,SHP-2,SHP2
1 APIs:
209 Possible Orthologues:

MET activates PTPN11 R-HSA-8865999
IRS-related events triggered by IGF1R R-HSA-2428928
GAB1 signalosome R-HSA-180292
Signaling by FGFR1 R-HSA-5654736
PIP3 activates AKT signaling R-HSA-1257604
Downstream signaling of activated FGFR3 R-HSA-5654708
FRS-mediated FGFR4 signaling R-HSA-5654712
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MyD88-independent TLR4 cascade R-HSA-166166
Signal regulatory protein family interactions R-HSA-391160
Nervous system development R-HSA-9675108
Interleukin-1 family signaling R-HSA-446652
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Cell-Cell communication R-HSA-1500931
Hemostasis R-HSA-109582
Prolactin receptor signaling R-HSA-1170546
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by PDGF R-HSA-186797
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Signaling by EGFR R-HSA-177929
Signaling by FGFR1 R-HSA-5654736
FRS-mediated FGFR3 signaling R-HSA-5654706
Interleukin-20 family signaling R-HSA-8854691
PECAM1 interactions R-HSA-210990
IGF1R signaling cascade R-HSA-2428924
Signaling by CSF3 (G-CSF) R-HSA-9674555
MAPK1/MAPK3 signaling R-HSA-5684996
Infectious disease R-HSA-5663205
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
MET activates PTPN11 R-HSA-8865999
Interleukin-37 signaling R-HSA-9008059
FLT3 signaling in disease R-HSA-9682385
Spry regulation of FGF signaling R-HSA-1295596
Interleukin-6 family signaling R-HSA-6783589
CTLA4 inhibitory signaling R-HSA-389513
Intracellular signaling by second messengers R-HSA-9006925
Gene expression (Transcription) R-HSA-74160
Interferon alpha/beta signaling R-HSA-909733
Interferon Signaling R-HSA-913531
Downstream signaling of activated FGFR1 R-HSA-5654687
Tie2 Signaling R-HSA-210993
Downstream signaling of activated FGFR4 R-HSA-5654716
Toll-like Receptor Cascades R-HSA-168898
Insulin receptor signalling cascade R-HSA-74751
IRS-mediated signalling R-HSA-112399
Interferon gamma signaling R-HSA-877300
PI3K Cascade R-HSA-109704
FLT3 Signaling R-HSA-9607240
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
MAPK1 (ERK2) activation R-HSA-112411
Platelet activation, signaling and aggregation R-HSA-76002
STAT5 Activation R-HSA-9645135
Interleukin-6 signaling R-HSA-1059683
Signaling by Interleukins R-HSA-449147
PD-1 signaling R-HSA-389948
Netrin-1 signaling R-HSA-373752
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
FRS-mediated FGFR1 signaling R-HSA-5654693
GPVI-mediated activation cascade R-HSA-114604
PI-3K cascade:FGFR4 R-HSA-5654720
PI-3K cascade:FGFR2 R-HSA-5654695
Negative regulation of FGFR2 signaling R-HSA-5654727
Signal Transduction R-HSA-162582
Regulation of IFNG signaling R-HSA-877312
Signaling by Insulin receptor R-HSA-74752
Downstream signaling of activated FGFR2 R-HSA-5654696
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by FGFR3 R-HSA-5654741
Transcriptional regulation by RUNX1 R-HSA-8878171
Netrin mediated repulsion signals R-HSA-418886
FRS-mediated FGFR2 signaling R-HSA-5654700
MAPK3 (ERK1) activation R-HSA-110056
RAF-independent MAPK1/3 activation R-HSA-112409
GAB1 signalosome R-HSA-180292
Negative regulation of FGFR1 signaling R-HSA-5654726
Innate Immune System R-HSA-168249
Signaling by NTRK2 (TRKB) R-HSA-9006115
Developmental Biology R-HSA-1266738
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Immune System R-HSA-168256
PI-3K cascade:FGFR3 R-HSA-5654710
Adaptive Immune System R-HSA-1280218
Signaling by FGFR4 R-HSA-5654743
RET signaling R-HSA-8853659
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Costimulation by the CD28 family R-HSA-388841
Cytokine Signaling in Immune system R-HSA-1280215
PI-3K cascade:FGFR1 R-HSA-5654689
Downstream signal transduction R-HSA-186763
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by MET R-HSA-6806834
Platelet homeostasis R-HSA-418346
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by SCF-KIT R-HSA-1433557
SARS-CoV-2 Infection R-HSA-9694516
Axon guidance R-HSA-422475
IRS-related events triggered by IGF1R R-HSA-2428928
Regulation of IFNA/IFNB signaling R-HSA-912694
Negative regulation of the PI3K/AKT network R-HSA-199418
Disease R-HSA-1643685
SARS-CoV Infections R-HSA-9679506
Platelet sensitization by LDL R-HSA-432142
Signaling by Leptin R-HSA-2586552
Signaling by FGFR2 R-HSA-5654738
SARS-CoV-2-host interactions R-HSA-9705683
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR R-HSA-190236
Signaling by NTRKs R-HSA-166520
Adaptive Immune System R-HSA-1280218
Downstream signaling of activated FGFR3 R-HSA-5654708
Axon guidance R-HSA-422475
Insulin receptor signalling cascade R-HSA-74751
Signaling by EGFR R-HSA-177929
Signal regulatory protein family interactions R-HSA-391160
Downstream signal transduction R-HSA-186763
IGF1R signaling cascade R-HSA-2428924
Developmental Biology R-HSA-1266738
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
GAB1 signalosome R-HSA-180292
Infectious disease R-HSA-5663205
Toll-like Receptor Cascades R-HSA-168898
Nervous system development R-HSA-9675108
PI3K Cascade R-HSA-109704
Interleukin-6 family signaling R-HSA-6783589
Costimulation by the CD28 family R-HSA-388841
FLT3 Signaling R-HSA-9607240
Downstream signaling of activated FGFR2 R-HSA-5654696
Cell-Cell communication R-HSA-1500931
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Platelet homeostasis R-HSA-418346
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Interleukin-37 signaling R-HSA-9008059
Signaling by MET R-HSA-6806834
Netrin mediated repulsion signals R-HSA-418886
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR3 R-HSA-5654741
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
MAPK3 (ERK1) activation R-HSA-110056
Signaling by FGFR2 R-HSA-5654738
Disease R-HSA-1643685
Regulation of IFNA/IFNB signaling R-HSA-912694
Signaling by Interleukins R-HSA-449147
SARS-CoV-2-host interactions R-HSA-9705683
IRS-mediated signalling R-HSA-112399
STAT5 Activation R-HSA-9645135
Hemostasis R-HSA-109582
Netrin-1 signaling R-HSA-373752
Signaling by FGFR4 R-HSA-5654743
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by CSF3 (G-CSF) R-HSA-9674555
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by Leptin R-HSA-2586552
Interferon alpha/beta signaling R-HSA-909733
Signaling by PDGF R-HSA-186797
Intracellular signaling by second messengers R-HSA-9006925
FRS-mediated FGFR3 signaling R-HSA-5654706
PD-1 signaling R-HSA-389948
PI-3K cascade:FGFR3 R-HSA-5654710
PIP3 activates AKT signaling R-HSA-1257604
PI3K/AKT Signaling in Cancer R-HSA-2219528
SARS-CoV-2 Infection R-HSA-9694516
Signaling by SCF-KIT R-HSA-1433557
Platelet activation, signaling and aggregation R-HSA-76002
Cytokine Signaling in Immune system R-HSA-1280215
FRS-mediated FGFR1 signaling R-HSA-5654693
MyD88-independent TLR4 cascade R-HSA-166166
Generic Transcription Pathway R-HSA-212436
Platelet sensitization by LDL R-HSA-432142
PI-3K cascade:FGFR1 R-HSA-5654689
Negative regulation of FGFR4 signaling R-HSA-5654733
Tie2 Signaling R-HSA-210993
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Interleukin-20 family signaling R-HSA-8854691
Downstream signaling of activated FGFR1 R-HSA-5654687
RET signaling R-HSA-8853659
Negative regulation of FGFR1 signaling R-HSA-5654726
IRS-related events triggered by IGF1R R-HSA-2428928
Interferon gamma signaling R-HSA-877300
GPVI-mediated activation cascade R-HSA-114604
Cell surface interactions at the vascular wall R-HSA-202733
Regulation of IFNG signaling R-HSA-877312
Gene expression (Transcription) R-HSA-74160
MAPK1 (ERK2) activation R-HSA-112411
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Negative regulation of FGFR2 signaling R-HSA-5654727
MET activates PTPN11 R-HSA-8865999
Transcriptional regulation by RUNX1 R-HSA-8878171
CTLA4 inhibitory signaling R-HSA-389513
Signaling by NTRK2 (TRKB) R-HSA-9006115
Prolactin receptor signaling R-HSA-1170546
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
FRS-mediated FGFR4 signaling R-HSA-5654712
Spry regulation of FGF signaling R-HSA-1295596
Signaling by NTRKs R-HSA-166520
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Interleukin-6 signaling R-HSA-1059683
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR1 R-HSA-5654736
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Regulation of RUNX1 Expression and Activity R-HSA-8934593
MAPK family signaling cascades R-HSA-5683057
Interferon Signaling R-HSA-913531
SARS-CoV Infections R-HSA-9679506
Interleukin-1 family signaling R-HSA-446652
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by FGFR R-HSA-190236
Signaling by Insulin receptor R-HSA-74752
PECAM1 interactions R-HSA-210990
RAF-independent MAPK1/3 activation R-HSA-112409
RNA Polymerase II Transcription R-HSA-73857
FRS-mediated FGFR2 signaling R-HSA-5654700
FLT3 signaling in disease R-HSA-9682385
PI-3K cascade:FGFR2 R-HSA-5654695
PI-3K cascade:FGFR4 R-HSA-5654720
Netrin-1 signaling R-HSA-373752
Signaling by Insulin receptor R-HSA-74752
Signaling by MET R-HSA-6806834
Platelet sensitization by LDL R-HSA-432142
RET signaling R-HSA-8853659
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by FGFR1 R-HSA-5654736
Toll-like Receptor Cascades R-HSA-168898
Signaling by Interleukins R-HSA-449147
STAT5 Activation R-HSA-9645135
Transcriptional regulation by RUNX1 R-HSA-8878171
FLT3 Signaling R-HSA-9607240
Negative regulation of FGFR3 signaling R-HSA-5654732
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Intracellular signaling by second messengers R-HSA-9006925
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by FGFR3 R-HSA-5654741
Signal Transduction R-HSA-162582
FRS-mediated FGFR4 signaling R-HSA-5654712
IGF1R signaling cascade R-HSA-2428924
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
GAB1 signalosome R-HSA-180292
Interleukin-1 family signaling R-HSA-446652
Prolactin receptor signaling R-HSA-1170546
Signaling by SCF-KIT R-HSA-1433557
Signaling by EGFR R-HSA-177929
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Disease R-HSA-1643685
Signal regulatory protein family interactions R-HSA-391160
Hemostasis R-HSA-109582
Signaling by FGFR2 R-HSA-5654738
Innate Immune System R-HSA-168249
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by PDGF R-HSA-186797
Signaling by FGFR R-HSA-190236
FRS-mediated FGFR2 signaling R-HSA-5654700
Interferon gamma signaling R-HSA-877300
Netrin mediated repulsion signals R-HSA-418886
Cell surface interactions at the vascular wall R-HSA-202733
Cell-Cell communication R-HSA-1500931
Negative regulation of FGFR4 signaling R-HSA-5654733
Developmental Biology R-HSA-1266738
Signaling by CSF3 (G-CSF) R-HSA-9674555
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Downstream signaling of activated FGFR1 R-HSA-5654687
Cytokine Signaling in Immune system R-HSA-1280215
FLT3 signaling in disease R-HSA-9682385
Interleukin-20 family signaling R-HSA-8854691
PI-3K cascade:FGFR1 R-HSA-5654689
Interleukin-37 signaling R-HSA-9008059
Nervous system development R-HSA-9675108
Interferon alpha/beta signaling R-HSA-909733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Adaptive Immune System R-HSA-1280218
Infectious disease R-HSA-5663205
Interferon Signaling R-HSA-913531
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PD-1 signaling R-HSA-389948
Signaling by Leptin R-HSA-2586552
MAPK3 (ERK1) activation R-HSA-110056
Downstream signal transduction R-HSA-186763
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by NTRKs R-HSA-166520
MAPK family signaling cascades R-HSA-5683057
Axon guidance R-HSA-422475
Negative regulation of FGFR1 signaling R-HSA-5654726
MAPK1 (ERK2) activation R-HSA-112411
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR4 R-HSA-5654743
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
MAPK1/MAPK3 signaling R-HSA-5684996
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
Downstream signaling of activated FGFR2 R-HSA-5654696
SARS-CoV-2-host interactions R-HSA-9705683
PI-3K cascade:FGFR4 R-HSA-5654720
Regulation of IFNG signaling R-HSA-877312
PI-3K cascade:FGFR3 R-HSA-5654710
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K Cascade R-HSA-109704
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
SARS-CoV Infections R-HSA-9679506
Immune System R-HSA-168256
PI3K/AKT Signaling in Cancer R-HSA-2219528
RNA Polymerase II Transcription R-HSA-73857
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
CTLA4 inhibitory signaling R-HSA-389513
Spry regulation of FGF signaling R-HSA-1295596
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Regulation of IFNA/IFNB signaling R-HSA-912694
PECAM1 interactions R-HSA-210990
Platelet homeostasis R-HSA-418346
Platelet activation, signaling and aggregation R-HSA-76002
Costimulation by the CD28 family R-HSA-388841
Downstream signaling of activated FGFR3 R-HSA-5654708
FRS-mediated FGFR3 signaling R-HSA-5654706
Interleukin-6 family signaling R-HSA-6783589
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
GPVI-mediated activation cascade R-HSA-114604
RAF-independent MAPK1/3 activation R-HSA-112409
Downstream signaling of activated FGFR4 R-HSA-5654716
Tie2 Signaling R-HSA-210993
Interleukin-6 signaling R-HSA-1059683
FRS-mediated FGFR1 signaling R-HSA-5654693
SARS-CoV-2 Infection R-HSA-9694516
Insulin receptor signalling cascade R-HSA-74751
Costimulation by the CD28 family R-HSA-388841
Downstream signaling of activated FGFR1 R-HSA-5654687
PI-3K cascade:FGFR1 R-HSA-5654689
FRS-mediated FGFR2 signaling R-HSA-5654700
RET signaling R-HSA-8853659
Signal regulatory protein family interactions R-HSA-391160
Disease R-HSA-1643685
Axon guidance R-HSA-422475
Regulation of IFNG signaling R-HSA-877312
Negative regulation of FGFR3 signaling R-HSA-5654732
Infectious disease R-HSA-5663205
Interleukin-6 signaling R-HSA-1059683
SARS-CoV Infections R-HSA-9679506
FRS-mediated FGFR3 signaling R-HSA-5654706
FRS-mediated FGFR4 signaling R-HSA-5654712
Netrin-1 signaling R-HSA-373752
Interferon Signaling R-HSA-913531
SARS-CoV-2 Infection R-HSA-9694516
PD-1 signaling R-HSA-389948
Signaling by FGFR1 R-HSA-5654736
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by Leptin R-HSA-2586552
Interferon alpha/beta signaling R-HSA-909733
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signal Transduction R-HSA-162582
Downstream signaling of activated FGFR2 R-HSA-5654696
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR R-HSA-190236
Transcriptional regulation by RUNX1 R-HSA-8878171
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Developmental Biology R-HSA-1266738
Signaling by FGFR3 R-HSA-5654741
Negative regulation of the PI3K/AKT network R-HSA-199418
MAPK3 (ERK1) activation R-HSA-110056
Negative regulation of FGFR1 signaling R-HSA-5654726
IGF1R signaling cascade R-HSA-2428924
Cytokine Signaling in Immune system R-HSA-1280215
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by MET R-HSA-6806834
MAPK family signaling cascades R-HSA-5683057
Platelet sensitization by LDL R-HSA-432142
RNA Polymerase II Transcription R-HSA-73857
IRS-mediated signalling R-HSA-112399
PI-3K cascade:FGFR3 R-HSA-5654710
PECAM1 interactions R-HSA-210990
IRS-related events triggered by IGF1R R-HSA-2428928
FLT3 Signaling R-HSA-9607240
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by NTRK2 (TRKB) R-HSA-9006115
SARS-CoV-2-host interactions R-HSA-9705683
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
MET activates PTPN11 R-HSA-8865999
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
FLT3 signaling in disease R-HSA-9682385
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Adaptive Immune System R-HSA-1280218
Signaling by NTRKs R-HSA-166520
Gene expression (Transcription) R-HSA-74160
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Netrin mediated repulsion signals R-HSA-418886
Signaling by Insulin receptor R-HSA-74752
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Negative regulation of FGFR2 signaling R-HSA-5654727
Spry regulation of FGF signaling R-HSA-1295596
MyD88-independent TLR4 cascade R-HSA-166166
CTLA4 inhibitory signaling R-HSA-389513
GPVI-mediated activation cascade R-HSA-114604
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Negative regulation of FGFR4 signaling R-HSA-5654733
Nervous system development R-HSA-9675108
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by CSF3 (G-CSF) R-HSA-9674555
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Platelet homeostasis R-HSA-418346
Prolactin receptor signaling R-HSA-1170546
STAT5 Activation R-HSA-9645135
PI3K Cascade R-HSA-109704
Regulation of IFNA/IFNB signaling R-HSA-912694
Innate Immune System R-HSA-168249
Signaling by EGFR R-HSA-177929
Interleukin-37 signaling R-HSA-9008059
Interferon gamma signaling R-HSA-877300
Signaling by FGFR2 R-HSA-5654738
Interleukin-6 family signaling R-HSA-6783589
Signaling by Interleukins R-HSA-449147
Intracellular signaling by second messengers R-HSA-9006925
Immune System R-HSA-168256
MAPK1 (ERK2) activation R-HSA-112411
Signaling by SCF-KIT R-HSA-1433557
Toll-like Receptor Cascades R-HSA-168898
Downstream signal transduction R-HSA-186763
FRS-mediated FGFR1 signaling R-HSA-5654693
GAB1 signalosome R-HSA-180292
Tie2 Signaling R-HSA-210993
Generic Transcription Pathway R-HSA-212436
Interleukin-20 family signaling R-HSA-8854691
Cell-Cell communication R-HSA-1500931
Platelet activation, signaling and aggregation R-HSA-76002
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
PIP3 activates AKT signaling R-HSA-1257604
RAF-independent MAPK1/3 activation R-HSA-112409
Cell surface interactions at the vascular wall R-HSA-202733
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR4 R-HSA-5654743
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by PDGF R-HSA-186797
Interleukin-1 family signaling R-HSA-446652
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
PI-3K cascade:FGFR4 R-HSA-5654720
Hemostasis R-HSA-109582
IGF1R signaling cascade R-HSA-2428924
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by MET R-HSA-6806834
FRS-mediated FGFR3 signaling R-HSA-5654706
GPVI-mediated activation cascade R-HSA-114604
Axon guidance R-HSA-422475
Downstream signaling of activated FGFR1 R-HSA-5654687
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by FGFR2 R-HSA-5654738
Generic Transcription Pathway R-HSA-212436
Spry regulation of FGF signaling R-HSA-1295596
Netrin-1 signaling R-HSA-373752
Interferon gamma signaling R-HSA-877300
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Infectious disease R-HSA-5663205
Interleukin-37 signaling R-HSA-9008059
RET signaling R-HSA-8853659
Signaling by Leptin R-HSA-2586552
Platelet sensitization by LDL R-HSA-432142
Costimulation by the CD28 family R-HSA-388841
Downstream signal transduction R-HSA-186763
SARS-CoV-2 Infection R-HSA-9694516
Signaling by CSF3 (G-CSF) R-HSA-9674555
GAB1 signalosome R-HSA-180292
Signaling by NTRKs R-HSA-166520
Interleukin-1 family signaling R-HSA-446652
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
RNA Polymerase II Transcription R-HSA-73857
IRS-mediated signalling R-HSA-112399
Platelet homeostasis R-HSA-418346
Signaling by SCF-KIT R-HSA-1433557
Cytokine Signaling in Immune system R-HSA-1280215
Developmental Biology R-HSA-1266738
Negative regulation of FGFR2 signaling R-HSA-5654727
Interleukin-6 family signaling R-HSA-6783589
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by PDGF R-HSA-186797
MAPK1 (ERK2) activation R-HSA-112411
Signaling by FGFR4 R-HSA-5654743
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Gene expression (Transcription) R-HSA-74160
Interleukin-20 family signaling R-HSA-8854691
PIP3 activates AKT signaling R-HSA-1257604
Downstream signaling of activated FGFR2 R-HSA-5654696
Netrin mediated repulsion signals R-HSA-418886
Downstream signaling of activated FGFR4 R-HSA-5654716
SARS-CoV Infections R-HSA-9679506
PI3K Cascade R-HSA-109704
FRS-mediated FGFR2 signaling R-HSA-5654700
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR1 signaling R-HSA-5654693
FRS-mediated FGFR4 signaling R-HSA-5654712
Cell-Cell communication R-HSA-1500931
Transcriptional regulation by RUNX1 R-HSA-8878171
Prolactin receptor signaling R-HSA-1170546
Interferon Signaling R-HSA-913531
Toll-like Receptor Cascades R-HSA-168898
Interferon alpha/beta signaling R-HSA-909733
Adaptive Immune System R-HSA-1280218
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR3 R-HSA-5654741
Tie2 Signaling R-HSA-210993
Disease R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Regulation of RUNX1 Expression and Activity R-HSA-8934593
MET activates PTPN11 R-HSA-8865999
Signaling by Insulin receptor R-HSA-74752
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
MyD88-independent TLR4 cascade R-HSA-166166
PI-3K cascade:FGFR4 R-HSA-5654720
Regulation of IFNG signaling R-HSA-877312
Interleukin-6 signaling R-HSA-1059683
Signal Transduction R-HSA-162582
Signaling by NTRK2 (TRKB) R-HSA-9006115
Cell surface interactions at the vascular wall R-HSA-202733
Insulin receptor signalling cascade R-HSA-74751
Hemostasis R-HSA-109582
SARS-CoV-2-host interactions R-HSA-9705683
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Nervous system development R-HSA-9675108
Innate Immune System R-HSA-168249
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K/AKT Signaling in Cancer R-HSA-2219528
Platelet activation, signaling and aggregation R-HSA-76002
STAT5 Activation R-HSA-9645135
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by EGFR R-HSA-177929
PD-1 signaling R-HSA-389948
Regulation of IFNA/IFNB signaling R-HSA-912694
Signaling by FGFR1 R-HSA-5654736
Signal regulatory protein family interactions R-HSA-391160
MAPK family signaling cascades R-HSA-5683057
PI-3K cascade:FGFR1 R-HSA-5654689
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR4 signaling R-HSA-5654733
Immune System R-HSA-168256
MAPK3 (ERK1) activation R-HSA-110056
Intracellular signaling by second messengers R-HSA-9006925
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
CTLA4 inhibitory signaling R-HSA-389513
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PECAM1 interactions R-HSA-210990
FLT3 signaling in disease R-HSA-9682385
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Interleukins R-HSA-449147
Signaling by FGFR3 R-HSA-5654741
Immune System R-HSA-168256
STAT5 Activation R-HSA-9645135
MAPK family signaling cascades R-HSA-5683057
RET signaling R-HSA-8853659
IRS-related events triggered by IGF1R R-HSA-2428928
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by EGFR R-HSA-177929
MAPK1 (ERK2) activation R-HSA-112411
CTLA4 inhibitory signaling R-HSA-389513
Signaling by PDGF R-HSA-186797
Signaling by CSF3 (G-CSF) R-HSA-9674555
Innate Immune System R-HSA-168249
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Hemostasis R-HSA-109582
Intracellular signaling by second messengers R-HSA-9006925
GPVI-mediated activation cascade R-HSA-114604
Platelet activation, signaling and aggregation R-HSA-76002
MAPK3 (ERK1) activation R-HSA-110056
Negative regulation of FGFR4 signaling R-HSA-5654733
FRS-mediated FGFR4 signaling R-HSA-5654712
Interleukin-6 signaling R-HSA-1059683
Cell surface interactions at the vascular wall R-HSA-202733
Interleukin-1 family signaling R-HSA-446652
Interferon Signaling R-HSA-913531
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Regulation of RUNX1 Expression and Activity R-HSA-8934593
IGF1R signaling cascade R-HSA-2428924
Interferon gamma signaling R-HSA-877300
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K Cascade R-HSA-109704
PI3K/AKT Signaling in Cancer R-HSA-2219528
Toll-like Receptor Cascades R-HSA-168898
Downstream signaling of activated FGFR3 R-HSA-5654708
Downstream signaling of activated FGFR4 R-HSA-5654716
Prolactin receptor signaling R-HSA-1170546
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR R-HSA-190236
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Adaptive Immune System R-HSA-1280218
Signaling by NTRK2 (TRKB) R-HSA-9006115
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by MET R-HSA-6806834
Signaling by Leptin R-HSA-2586552
Platelet homeostasis R-HSA-418346
Signaling by FGFR1 R-HSA-5654736
Netrin mediated repulsion signals R-HSA-418886
Signal regulatory protein family interactions R-HSA-391160
PI-3K cascade:FGFR2 R-HSA-5654695
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by Insulin receptor R-HSA-74752
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Platelet sensitization by LDL R-HSA-432142
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SARS-CoV Infections R-HSA-9679506
Downstream signal transduction R-HSA-186763
Signaling by SCF-KIT R-HSA-1433557
RNA Polymerase II Transcription R-HSA-73857
Nervous system development R-HSA-9675108
Infectious disease R-HSA-5663205
PI-3K cascade:FGFR4 R-HSA-5654720
SARS-CoV-2 Infection R-HSA-9694516
Transcriptional regulation by RUNX1 R-HSA-8878171
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR1 signaling R-HSA-5654693
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
PECAM1 interactions R-HSA-210990
Developmental Biology R-HSA-1266738
MyD88-independent TLR4 cascade R-HSA-166166
FRS-mediated FGFR3 signaling R-HSA-5654706
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Negative regulation of FGFR2 signaling R-HSA-5654727
Downstream signaling of activated FGFR2 R-HSA-5654696
Spry regulation of FGF signaling R-HSA-1295596
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
Signaling by FGFR2 R-HSA-5654738
MET activates PTPN11 R-HSA-8865999
PI-3K cascade:FGFR3 R-HSA-5654710
Interleukin-20 family signaling R-HSA-8854691
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
IRS-mediated signalling R-HSA-112399
RAF-independent MAPK1/3 activation R-HSA-112409
Costimulation by the CD28 family R-HSA-388841
Netrin-1 signaling R-HSA-373752
Cell-Cell communication R-HSA-1500931
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by FGFR4 R-HSA-5654743
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Axon guidance R-HSA-422475
Downstream signaling of activated FGFR1 R-HSA-5654687
Regulation of IFNG signaling R-HSA-877312
Tie2 Signaling R-HSA-210993
Interferon alpha/beta signaling R-HSA-909733
FLT3 signaling in disease R-HSA-9682385
Signal Transduction R-HSA-162582
PD-1 signaling R-HSA-389948
Interleukin-6 family signaling R-HSA-6783589
Interleukin-37 signaling R-HSA-9008059
Signaling by Interleukins R-HSA-449147
Negative regulation of FGFR3 signaling R-HSA-5654732
Generic Transcription Pathway R-HSA-212436
Regulation of IFNA/IFNB signaling R-HSA-912694
Insulin receptor signalling cascade R-HSA-74751
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
GPVI-mediated activation cascade R-HSA-114604
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by CSF3 (G-CSF) R-HSA-9674555
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FLT3 signaling in disease R-HSA-9682385
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional regulation by RUNX1 R-HSA-8878171
Interleukin-6 signaling R-HSA-1059683
Netrin-1 signaling R-HSA-373752
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Negative regulation of FGFR2 signaling R-HSA-5654727
Cell surface interactions at the vascular wall R-HSA-202733
Platelet homeostasis R-HSA-418346
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by FGFR4 R-HSA-5654743
RAF-independent MAPK1/3 activation R-HSA-112409
Regulation of IFNA/IFNB signaling R-HSA-912694
Developmental Biology R-HSA-1266738
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by PDGF R-HSA-186797
Interleukin-6 family signaling R-HSA-6783589
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Hemostasis R-HSA-109582
Interferon Signaling R-HSA-913531
Adaptive Immune System R-HSA-1280218
Downstream signaling of activated FGFR3 R-HSA-5654708
PI-3K cascade:FGFR3 R-HSA-5654710
Infectious disease R-HSA-5663205
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Nervous system development R-HSA-9675108
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
SARS-CoV-2 Infection R-HSA-9694516
Tie2 Signaling R-HSA-210993
MAPK1 (ERK2) activation R-HSA-112411
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by FGFR R-HSA-190236
Interferon gamma signaling R-HSA-877300
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Interleukin-20 family signaling R-HSA-8854691
Signaling by NTRKs R-HSA-166520
MET activates PTPN11 R-HSA-8865999
Cell-Cell communication R-HSA-1500931
IGF1R signaling cascade R-HSA-2428924
Signaling by FGFR2 R-HSA-5654738
Downstream signaling of activated FGFR2 R-HSA-5654696
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
MyD88-independent TLR4 cascade R-HSA-166166
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interleukin-1 family signaling R-HSA-446652
Interleukin-37 signaling R-HSA-9008059
IRS-related events triggered by IGF1R R-HSA-2428928
PI-3K cascade:FGFR1 R-HSA-5654689
Generic Transcription Pathway R-HSA-212436
Signaling by EGFR R-HSA-177929
Interferon alpha/beta signaling R-HSA-909733
FRS-mediated FGFR4 signaling R-HSA-5654712
Axon guidance R-HSA-422475
PECAM1 interactions R-HSA-210990
Intracellular signaling by second messengers R-HSA-9006925
Signaling by Insulin receptor R-HSA-74752
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Immune System R-HSA-168256
PI-3K cascade:FGFR4 R-HSA-5654720
Insulin receptor signalling cascade R-HSA-74751
PI3K/AKT Signaling in Cancer R-HSA-2219528
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
FLT3 Signaling R-HSA-9607240
RET signaling R-HSA-8853659
MAPK family signaling cascades R-HSA-5683057
Toll-like Receptor Cascades R-HSA-168898
Regulation of IFNG signaling R-HSA-877312
Signaling by FGFR1 R-HSA-5654736
Costimulation by the CD28 family R-HSA-388841
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PIP3 activates AKT signaling R-HSA-1257604
MAPK3 (ERK1) activation R-HSA-110056
Regulation of RUNX1 Expression and Activity R-HSA-8934593
FRS-mediated FGFR3 signaling R-HSA-5654706
IRS-mediated signalling R-HSA-112399
PD-1 signaling R-HSA-389948
Signal regulatory protein family interactions R-HSA-391160
STAT5 Activation R-HSA-9645135
Prolactin receptor signaling R-HSA-1170546
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Downstream signal transduction R-HSA-186763
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR3 signaling R-HSA-5654732
PI-3K cascade:FGFR2 R-HSA-5654695
Netrin mediated repulsion signals R-HSA-418886
Innate Immune System R-HSA-168249
PI3K Cascade R-HSA-109704
Platelet sensitization by LDL R-HSA-432142
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by Leptin R-HSA-2586552
Spry regulation of FGF signaling R-HSA-1295596
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by Interleukins R-HSA-449147
Platelet activation, signaling and aggregation R-HSA-76002
Downstream signaling of activated FGFR1 R-HSA-5654687
FRS-mediated FGFR1 signaling R-HSA-5654693
GAB1 signalosome R-HSA-180292
MAPK1/MAPK3 signaling R-HSA-5684996
CTLA4 inhibitory signaling R-HSA-389513
Signaling by MET R-HSA-6806834
Signaling by SCF-KIT R-HSA-1433557
SARS-CoV Infections R-HSA-9679506
Signaling by FGFR3 R-HSA-5654741
Interleukin-37 signaling R-HSA-9008059
PI-3K cascade:FGFR1 R-HSA-5654689
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
MAPK family signaling cascades R-HSA-5683057
Interleukin-6 signaling R-HSA-1059683
Transcriptional regulation by RUNX1 R-HSA-8878171
Toll-like Receptor Cascades R-HSA-168898
Insulin receptor signalling cascade R-HSA-74751
Signaling by SCF-KIT R-HSA-1433557
Infectious disease R-HSA-5663205
Gene expression (Transcription) R-HSA-74160
Nervous system development R-HSA-9675108
SARS-CoV Infections R-HSA-9679506
FLT3 Signaling R-HSA-9607240
Cell-Cell communication R-HSA-1500931
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signal regulatory protein family interactions R-HSA-391160
Disease R-HSA-1643685
Downstream signal transduction R-HSA-186763
STAT5 Activation R-HSA-9645135
Signaling by Interleukins R-HSA-449147
Signaling by FGFR2 R-HSA-5654738
PI-3K cascade:FGFR4 R-HSA-5654720
MAPK3 (ERK1) activation R-HSA-110056
Immune System R-HSA-168256
Signaling by EGFR R-HSA-177929
Interferon gamma signaling R-HSA-877300
Interferon Signaling R-HSA-913531
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by Leptin R-HSA-2586552
Interleukin-6 family signaling R-HSA-6783589
Signaling by MET R-HSA-6806834
PI3K Cascade R-HSA-109704
FLT3 signaling in disease R-HSA-9682385
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
MAPK1/MAPK3 signaling R-HSA-5684996
PD-1 signaling R-HSA-389948
Signaling by Insulin receptor R-HSA-74752
Interferon alpha/beta signaling R-HSA-909733
Signaling by NTRKs R-HSA-166520
Innate Immune System R-HSA-168249
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Downstream signaling of activated FGFR4 R-HSA-5654716
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by CSF3 (G-CSF) R-HSA-9674555
Developmental Biology R-HSA-1266738
GPVI-mediated activation cascade R-HSA-114604
RET signaling R-HSA-8853659
Platelet sensitization by LDL R-HSA-432142
Netrin mediated repulsion signals R-HSA-418886
GAB1 signalosome R-HSA-180292
PECAM1 interactions R-HSA-210990
RNA Polymerase II Transcription R-HSA-73857
Interleukin-1 family signaling R-HSA-446652
PIP3 activates AKT signaling R-HSA-1257604
Regulation of IFNG signaling R-HSA-877312
Axon guidance R-HSA-422475
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin-20 family signaling R-HSA-8854691
Negative regulation of the PI3K/AKT network R-HSA-199418
Negative regulation of FGFR1 signaling R-HSA-5654726
MAPK1 (ERK2) activation R-HSA-112411
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Adaptive Immune System R-HSA-1280218
IRS-related events triggered by IGF1R R-HSA-2428928
MET activates PTPN11 R-HSA-8865999
Signaling by FGFR3 R-HSA-5654741
Signaling by PDGF R-HSA-186797
Negative regulation of FGFR4 signaling R-HSA-5654733
CTLA4 inhibitory signaling R-HSA-389513
FRS-mediated FGFR4 signaling R-HSA-5654712
RAF-independent MAPK1/3 activation R-HSA-112409
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signaling by FGFR R-HSA-190236
FRS-mediated FGFR2 signaling R-HSA-5654700
IRS-mediated signalling R-HSA-112399
Netrin-1 signaling R-HSA-373752
PI3K/AKT Signaling in Cancer R-HSA-2219528
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Platelet homeostasis R-HSA-418346
PI-3K cascade:FGFR3 R-HSA-5654710
Hemostasis R-HSA-109582
IGF1R signaling cascade R-HSA-2428924
FRS-mediated FGFR1 signaling R-HSA-5654693
Costimulation by the CD28 family R-HSA-388841
Negative regulation of FGFR3 signaling R-HSA-5654732
Negative regulation of FGFR2 signaling R-HSA-5654727
Platelet activation, signaling and aggregation R-HSA-76002
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR3 R-HSA-5654708
Spry regulation of FGF signaling R-HSA-1295596
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Generic Transcription Pathway R-HSA-212436
Downstream signaling of activated FGFR2 R-HSA-5654696
Signal Transduction R-HSA-162582
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Tie2 Signaling R-HSA-210993
SARS-CoV-2 Infection R-HSA-9694516
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR4 R-HSA-5654743
Cell surface interactions at the vascular wall R-HSA-202733
Prolactin receptor signaling R-HSA-1170546
PI-3K cascade:FGFR2 R-HSA-5654695
Intracellular signaling by second messengers R-HSA-9006925
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NTRK2 (TRKB) R-HSA-9006115
Platelet homeostasis R-HSA-418346
Signaling by Insulin receptor R-HSA-74752
Platelet activation, signaling and aggregation R-HSA-76002
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
PIP3 activates AKT signaling R-HSA-1257604
RET signaling R-HSA-8853659
STAT5 Activation R-HSA-9645135
PI3K/AKT Signaling in Cancer R-HSA-2219528
Interleukin-37 signaling R-HSA-9008059
PI-3K cascade:FGFR3 R-HSA-5654710
Interleukin-1 family signaling R-HSA-446652
Netrin-1 signaling R-HSA-373752
FRS-mediated FGFR4 signaling R-HSA-5654712
MAPK family signaling cascades R-HSA-5683057
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Insulin receptor signalling cascade R-HSA-74751
Regulation of IFNG signaling R-HSA-877312
Signaling by Interleukins R-HSA-449147
Signaling by EGFR R-HSA-177929
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Regulation of RUNX1 Expression and Activity R-HSA-8934593
PI3K Cascade R-HSA-109704
Disease R-HSA-1643685
Prolactin receptor signaling R-HSA-1170546
MET activates PTPN11 R-HSA-8865999
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR3 signaling R-HSA-5654706
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by FGFR1 R-HSA-5654736
GAB1 signalosome R-HSA-180292
Costimulation by the CD28 family R-HSA-388841
Spry regulation of FGF signaling R-HSA-1295596
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Platelet sensitization by LDL R-HSA-432142
MAPK3 (ERK1) activation R-HSA-110056
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
Adaptive Immune System R-HSA-1280218
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Toll-like Receptor Cascades R-HSA-168898
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FRS-mediated FGFR2 signaling R-HSA-5654700
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Downstream signaling of activated FGFR2 R-HSA-5654696
RAF-independent MAPK1/3 activation R-HSA-112409
Negative regulation of FGFR4 signaling R-HSA-5654733
PI-3K cascade:FGFR4 R-HSA-5654720
Downstream signaling of activated FGFR3 R-HSA-5654708
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Intracellular signaling by second messengers R-HSA-9006925
PI-3K cascade:FGFR2 R-HSA-5654695
IGF1R signaling cascade R-HSA-2428924
Downstream signal transduction R-HSA-186763
Developmental Biology R-HSA-1266738
Infectious disease R-HSA-5663205
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Nervous system development R-HSA-9675108
Negative regulation of FGFR2 signaling R-HSA-5654727
SARS-CoV-2 Infection R-HSA-9694516
MyD88-independent TLR4 cascade R-HSA-166166
CTLA4 inhibitory signaling R-HSA-389513
Signaling by FGFR3 R-HSA-5654741
GPVI-mediated activation cascade R-HSA-114604
Gene expression (Transcription) R-HSA-74160
Negative regulation of the PI3K/AKT network R-HSA-199418
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Cytokine Signaling in Immune system R-HSA-1280215
Tie2 Signaling R-HSA-210993
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by PDGF R-HSA-186797
Signaling by FGFR2 R-HSA-5654738
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Transcriptional regulation by RUNX1 R-HSA-8878171
Signaling by Leptin R-HSA-2586552
Signaling by MET R-HSA-6806834
Interferon Signaling R-HSA-913531
Interferon alpha/beta signaling R-HSA-909733
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Interleukin-20 family signaling R-HSA-8854691
Regulation of IFNA/IFNB signaling R-HSA-912694
Signal regulatory protein family interactions R-HSA-391160
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Generic Transcription Pathway R-HSA-212436
Hemostasis R-HSA-109582
Cell surface interactions at the vascular wall R-HSA-202733
SARS-CoV-2-host interactions R-HSA-9705683
PD-1 signaling R-HSA-389948
PI-3K cascade:FGFR1 R-HSA-5654689
RNA Polymerase II Transcription R-HSA-73857
PECAM1 interactions R-HSA-210990
Signaling by SCF-KIT R-HSA-1433557
Interleukin-6 family signaling R-HSA-6783589
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR R-HSA-190236
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR1 signaling R-HSA-5654726
SARS-CoV Infections R-HSA-9679506
Interleukin-6 signaling R-HSA-1059683
IRS-mediated signalling R-HSA-112399
Interferon gamma signaling R-HSA-877300
FLT3 signaling in disease R-HSA-9682385
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by CSF3 (G-CSF) R-HSA-9674555
Immune System R-HSA-168256
Signaling by FGFR4 R-HSA-5654743
Cell-Cell communication R-HSA-1500931
Netrin mediated repulsion signals R-HSA-418886
Innate Immune System R-HSA-168249
Prolactin receptor signaling R-HSA-1170546
Cell surface interactions at the vascular wall R-HSA-202733
FRS-mediated FGFR4 signaling R-HSA-5654712
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
PI3K/AKT Signaling in Cancer R-HSA-2219528
Immune System R-HSA-168256
PI3K Cascade R-HSA-109704
Signal Transduction R-HSA-162582
MyD88-independent TLR4 cascade R-HSA-166166
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR1 R-HSA-5654736
MAPK1 (ERK2) activation R-HSA-112411
PD-1 signaling R-HSA-389948
Downstream signal transduction R-HSA-186763
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by CSF3 (G-CSF) R-HSA-9674555
Axon guidance R-HSA-422475
Infectious disease R-HSA-5663205
Netrin mediated repulsion signals R-HSA-418886
Signaling by FGFR3 R-HSA-5654741
Generic Transcription Pathway R-HSA-212436
Interleukin-6 signaling R-HSA-1059683
Platelet activation, signaling and aggregation R-HSA-76002
FLT3 Signaling R-HSA-9607240
Signaling by FGFR R-HSA-190236
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by NTRKs R-HSA-166520
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PI-3K cascade:FGFR1 R-HSA-5654689
Transcriptional regulation by RUNX1 R-HSA-8878171
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Tie2 Signaling R-HSA-210993
GAB1 signalosome R-HSA-180292
PI-3K cascade:FGFR2 R-HSA-5654695
FLT3 signaling in disease R-HSA-9682385
Signaling by SCF-KIT R-HSA-1433557
Insulin receptor signalling cascade R-HSA-74751
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR R-HSA-177929
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by FGFR4 R-HSA-5654743
Innate Immune System R-HSA-168249
MET activates PTPN11 R-HSA-8865999
Adaptive Immune System R-HSA-1280218
IRS-mediated signalling R-HSA-112399
Interferon alpha/beta signaling R-HSA-909733
Nervous system development R-HSA-9675108
Intracellular signaling by second messengers R-HSA-9006925
Downstream signaling of activated FGFR3 R-HSA-5654708
Platelet homeostasis R-HSA-418346
GPVI-mediated activation cascade R-HSA-114604
Interferon Signaling R-HSA-913531
Signaling by MET R-HSA-6806834
Gene expression (Transcription) R-HSA-74160
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal regulatory protein family interactions R-HSA-391160
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
SARS-CoV Infections R-HSA-9679506
Cell-Cell communication R-HSA-1500931
CTLA4 inhibitory signaling R-HSA-389513
Negative regulation of FGFR1 signaling R-HSA-5654726
Interferon gamma signaling R-HSA-877300
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Regulation of IFNG signaling R-HSA-877312
Interleukin-20 family signaling R-HSA-8854691
Negative regulation of FGFR3 signaling R-HSA-5654732
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
PECAM1 interactions R-HSA-210990
Costimulation by the CD28 family R-HSA-388841
Negative regulation of FGFR2 signaling R-HSA-5654727
IGF1R signaling cascade R-HSA-2428924
Cytokine Signaling in Immune system R-HSA-1280215
RAF-independent MAPK1/3 activation R-HSA-112409
MAPK3 (ERK1) activation R-HSA-110056
Downstream signaling of activated FGFR1 R-HSA-5654687
STAT5 Activation R-HSA-9645135
Disease R-HSA-1643685
RET signaling R-HSA-8853659
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by Interleukins R-HSA-449147
Toll-like Receptor Cascades R-HSA-168898
Signaling by Leptin R-HSA-2586552
PIP3 activates AKT signaling R-HSA-1257604
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Platelet sensitization by LDL R-HSA-432142
Regulation of IFNA/IFNB signaling R-HSA-912694
Hemostasis R-HSA-109582
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by FGFR2 R-HSA-5654738
Developmental Biology R-HSA-1266738
Interleukin-6 family signaling R-HSA-6783589
Signaling by Insulin receptor R-HSA-74752
FRS-mediated FGFR3 signaling R-HSA-5654706
Netrin-1 signaling R-HSA-373752
SARS-CoV-2 Infection R-HSA-9694516
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by NTRK2 (TRKB) R-HSA-9006115
Interleukin-37 signaling R-HSA-9008059
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by PDGF R-HSA-186797
Interleukin-1 family signaling R-HSA-446652
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR4 R-HSA-5654716
FRS-mediated FGFR2 signaling R-HSA-5654700
MAPK family signaling cascades R-HSA-5683057
PI-3K cascade:FGFR4 R-HSA-5654720

Expression Atlas ENSG00000179295
LRG display in Ensembl gene LRG_614
NCBI gene (formerly Entrezgene) 5781
GeneCards 9644
HGNC Symbol HGNC:9644
MIM gene 176876
MIM morbid 607785
UniProtKB Gene Name Q06124
WikiGene 5781
Gene: SPHK2
Ensembl ID : ENSG00000063176
Description: sphingosine kinase 2
Gene Synonyms:
1 APIs:
209 Possible Orthologues:

Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661

Expression Atlas ENSG00000063176
NCBI gene (formerly Entrezgene) 56848
GeneCards 18859
HGNC Symbol HGNC:18859
MIM gene 607092
UniProtKB Gene Name Q9NRA0
WikiGene 56848