Gene: NCSTN
Ensembl ID : ENSG00000162736
Description: nicastrin
Gene Synonyms: APH2,KIAA0253
5 APIs:
204 Possible Orthologues:

Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Death Receptor Signaling R-HSA-73887
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH3 R-HSA-9012852
Nervous system development R-HSA-9675108
Amyloid fiber formation R-HSA-977225
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 in Cancer R-HSA-2644603
Extracellular matrix organization R-HSA-1474244
Degradation of the extracellular matrix R-HSA-1474228
Signal Transduction R-HSA-162582
Metabolism of proteins R-HSA-392499
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulated proteolysis of p75NTR R-HSA-193692
Disease R-HSA-1643685
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Neutrophil degranulation R-HSA-6798695
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Immune System R-HSA-168256
Signaling by ERBB4 R-HSA-1236394
Innate Immune System R-HSA-168249
Axon guidance R-HSA-422475
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH4 R-HSA-9013694
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by ERBB4 R-HSA-1236394
Neutrophil degranulation R-HSA-6798695
Amyloid fiber formation R-HSA-977225
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Developmental Biology R-HSA-1266738
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Innate Immune System R-HSA-168249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Immune System R-HSA-168256
Nuclear signaling by ERBB4 R-HSA-1251985
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH3 R-HSA-9012852
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Nervous system development R-HSA-9675108
Extracellular matrix organization R-HSA-1474244
Degradation of the extracellular matrix R-HSA-1474228
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
EPH-Ephrin signaling R-HSA-2682334
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Degradation of the extracellular matrix R-HSA-1474228
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Neutrophil degranulation R-HSA-6798695
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
p75 NTR receptor-mediated signalling R-HSA-193704
Noncanonical activation of NOTCH3 R-HSA-9017802
Regulated proteolysis of p75NTR R-HSA-193692
Death Receptor Signaling R-HSA-73887
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
Disease R-HSA-1643685
Innate Immune System R-HSA-168249
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Metabolism of proteins R-HSA-392499
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH2 R-HSA-1980145
Immune System R-HSA-168256
Signaling by NOTCH1 in Cancer R-HSA-2644603
Axon guidance R-HSA-422475
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nuclear signaling by ERBB4 R-HSA-1251985
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
NRIF signals cell death from the nucleus R-HSA-205043
Signal Transduction R-HSA-162582
p75 NTR receptor-mediated signalling R-HSA-193704
Degradation of the extracellular matrix R-HSA-1474228
Disease R-HSA-1643685
Neutrophil degranulation R-HSA-6798695
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Immune System R-HSA-168256
Nervous system development R-HSA-9675108
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH4 R-HSA-9013694
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Extracellular matrix organization R-HSA-1474244
Developmental Biology R-HSA-1266738
Regulated proteolysis of p75NTR R-HSA-193692
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Noncanonical activation of NOTCH3 R-HSA-9017802
Regulated proteolysis of p75NTR R-HSA-193692
Neutrophil degranulation R-HSA-6798695
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NRIF signals cell death from the nucleus R-HSA-205043
Death Receptor Signaling R-HSA-73887
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Metabolism of proteins R-HSA-392499
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Developmental Biology R-HSA-1266738
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH4 R-HSA-9013694
Nuclear signaling by ERBB4 R-HSA-1251985
Immune System R-HSA-168256
EPH-Ephrin signaling R-HSA-2682334
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Innate Immune System R-HSA-168249
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Amyloid fiber formation R-HSA-977225
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Degradation of the extracellular matrix R-HSA-1474228
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by ERBB4 R-HSA-1236394
Metabolism of proteins R-HSA-392499
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH R-HSA-157118
Axon guidance R-HSA-422475
Amyloid fiber formation R-HSA-977225
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Extracellular matrix organization R-HSA-1474244
Immune System R-HSA-168256
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH4 R-HSA-9013694
Developmental Biology R-HSA-1266738
Degradation of the extracellular matrix R-HSA-1474228
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Neutrophil degranulation R-HSA-6798695
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Noncanonical activation of NOTCH3 R-HSA-9017802
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH3 R-HSA-9012852
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
Innate Immune System R-HSA-168249
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 R-HSA-1980143
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Innate Immune System R-HSA-168249
Nervous system development R-HSA-9675108
p75 NTR receptor-mediated signalling R-HSA-193704
Death Receptor Signaling R-HSA-73887
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH4 R-HSA-9013694
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH2 R-HSA-1980145
NRIF signals cell death from the nucleus R-HSA-205043
Amyloid fiber formation R-HSA-977225
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 in Cancer R-HSA-2644603
Regulated proteolysis of p75NTR R-HSA-193692
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH3 R-HSA-9012852
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Extracellular matrix organization R-HSA-1474244
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Degradation of the extracellular matrix R-HSA-1474228
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Immune System R-HSA-168256
p75 NTR receptor-mediated signalling R-HSA-193704
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 in Cancer R-HSA-2644603
Amyloid fiber formation R-HSA-977225
Developmental Biology R-HSA-1266738
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH2 R-HSA-1980145
Nervous system development R-HSA-9675108
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Noncanonical activation of NOTCH3 R-HSA-9017802
Axon guidance R-HSA-422475
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
NRIF signals cell death from the nucleus R-HSA-205043
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Degradation of the extracellular matrix R-HSA-1474228
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH3 R-HSA-9012852
Death Receptor Signaling R-HSA-73887
Innate Immune System R-HSA-168249
Noncanonical activation of NOTCH3 R-HSA-9017802
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH4 R-HSA-9013694
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Extracellular matrix organization R-HSA-1474244
Neutrophil degranulation R-HSA-6798695
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Amyloid fiber formation R-HSA-977225
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Metabolism of proteins R-HSA-392499
Immune System R-HSA-168256
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH2 R-HSA-1980145
Axon guidance R-HSA-422475
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Innate Immune System R-HSA-168249
Metabolism of proteins R-HSA-392499
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NRIF signals cell death from the nucleus R-HSA-205043
Neutrophil degranulation R-HSA-6798695
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
EPH-ephrin mediated repulsion of cells R-HSA-3928665
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Developmental Biology R-HSA-1266738
Signaling by NOTCH R-HSA-157118
Amyloid fiber formation R-HSA-977225
Nuclear signaling by ERBB4 R-HSA-1251985
Regulated proteolysis of p75NTR R-HSA-193692
Immune System R-HSA-168256
Signaling by NOTCH4 R-HSA-9013694
Extracellular matrix organization R-HSA-1474244
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH4 R-HSA-9013694
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Noncanonical activation of NOTCH3 R-HSA-9017802
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Amyloid fiber formation R-HSA-977225
Immune System R-HSA-168256
Nervous system development R-HSA-9675108
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Degradation of the extracellular matrix R-HSA-1474228
p75 NTR receptor-mediated signalling R-HSA-193704
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB4 R-HSA-1236394
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
Neutrophil degranulation R-HSA-6798695
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Nuclear signaling by ERBB4 R-HSA-1251985
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603

Expression Atlas ENSG00000162736
LRG display in Ensembl gene LRG_223
NCBI gene (formerly Entrezgene) 23385
GeneCards 17091
HGNC Symbol HGNC:17091
MIM gene 605254
MIM morbid 142690
UniProtKB Gene Name Q92542
WikiGene 23385
Gene: APH1B
Ensembl ID : ENSG00000138613
Description: aph-1 homolog B, gamma-secretase subunit
Gene Synonyms: APH-1B,DKFZP564D0372,PSFL
5 APIs:
193 Possible Orthologues:

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH4 R-HSA-9013694
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Developmental Biology R-HSA-1266738
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Axon guidance R-HSA-422475
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH2 R-HSA-1980145
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NRIF signals cell death from the nucleus R-HSA-205043
Regulated proteolysis of p75NTR R-HSA-193692
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Nuclear signaling by ERBB4 R-HSA-1251985
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH1 in Cancer R-HSA-2644603
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH4 R-HSA-9013694
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
p75 NTR receptor-mediated signalling R-HSA-193704
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Axon guidance R-HSA-422475
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Metabolism of proteins R-HSA-392499
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Regulated proteolysis of p75NTR R-HSA-193692
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
NRIF signals cell death from the nucleus R-HSA-205043
Noncanonical activation of NOTCH3 R-HSA-9017802
Nervous system development R-HSA-9675108
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Metabolism of proteins R-HSA-392499
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Regulated proteolysis of p75NTR R-HSA-193692
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
NRIF signals cell death from the nucleus R-HSA-205043
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Disease R-HSA-1643685
Signaling by NOTCH1 R-HSA-1980143
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH4 R-HSA-9013694
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH4 R-HSA-9013694
Regulated proteolysis of p75NTR R-HSA-193692
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Signaling by NOTCH2 R-HSA-1980145
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH3 R-HSA-9012852
Death Receptor Signaling R-HSA-73887
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NRIF signals cell death from the nucleus R-HSA-205043
Developmental Biology R-HSA-1266738
Amyloid fiber formation R-HSA-977225
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by ERBB4 R-HSA-1236394
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nuclear signaling by ERBB4 R-HSA-1251985
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Amyloid fiber formation R-HSA-977225
Nervous system development R-HSA-9675108
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Nuclear signaling by ERBB4 R-HSA-1251985
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Developmental Biology R-HSA-1266738
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH R-HSA-157118
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 in Cancer R-HSA-2644603
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signal Transduction R-HSA-162582
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 R-HSA-1980143
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nervous system development R-HSA-9675108
Signaling by NOTCH1 in Cancer R-HSA-2644603
Regulated proteolysis of p75NTR R-HSA-193692
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH2 R-HSA-1980145
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Axon guidance R-HSA-422475
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Metabolism of proteins R-HSA-392499
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH2 R-HSA-1980145
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH R-HSA-157118
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Amyloid fiber formation R-HSA-977225
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH2 R-HSA-1980145
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signal Transduction R-HSA-162582
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH4 R-HSA-9013694
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 in Cancer R-HSA-2644603
Noncanonical activation of NOTCH3 R-HSA-9017802
Metabolism of proteins R-HSA-392499
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Amyloid fiber formation R-HSA-977225
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Amyloid fiber formation R-HSA-977225
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nervous system development R-HSA-9675108
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Regulated proteolysis of p75NTR R-HSA-193692
Noncanonical activation of NOTCH3 R-HSA-9017802
Signal Transduction R-HSA-162582
Nuclear signaling by ERBB4 R-HSA-1251985
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH3 R-HSA-9012852
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
NRIF signals cell death from the nucleus R-HSA-205043
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Signaling by NOTCH4 R-HSA-9013694
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH2 R-HSA-1980145

Expression Atlas ENSG00000138613
NCBI gene (formerly Entrezgene) 83464
GeneCards 24080
HGNC Symbol HGNC:24080
MIM gene 607630
UniProtKB Gene Name Q8WW43
WikiGene 83464
Gene: PSENEN
Ensembl ID : ENSG00000205155
Description: presenilin enhancer, gamma-secretase subunit
Gene Synonyms: PEN2
5 APIs:
185 Possible Orthologues:

Signaling by ERBB4 R-HSA-1236394
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH1 R-HSA-1980143
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nervous system development R-HSA-9675108
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
p75 NTR receptor-mediated signalling R-HSA-193704
Metabolism of proteins R-HSA-392499
Disease R-HSA-1643685
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH4 R-HSA-9013694
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Regulated proteolysis of p75NTR R-HSA-193692
Amyloid fiber formation R-HSA-977225
Signal Transduction R-HSA-162582
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH2 R-HSA-1980145
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-Ephrin signaling R-HSA-2682334
Signaling by ERBB4 R-HSA-1236394
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulated proteolysis of p75NTR R-HSA-193692
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Developmental Biology R-HSA-1266738
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Nuclear signaling by ERBB4 R-HSA-1251985
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH2 R-HSA-1980145
Disease R-HSA-1643685
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 R-HSA-1980143
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Amyloid fiber formation R-HSA-977225
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH4 R-HSA-9013694
Noncanonical activation of NOTCH3 R-HSA-9017802
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Axon guidance R-HSA-422475
Metabolism of proteins R-HSA-392499
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
Signaling by NOTCH1 in Cancer R-HSA-2644603
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH2 R-HSA-1980145
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Noncanonical activation of NOTCH3 R-HSA-9017802
Death Receptor Signaling R-HSA-73887
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH4 R-HSA-9013694
Nervous system development R-HSA-9675108
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
Nuclear signaling by ERBB4 R-HSA-1251985
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Axon guidance R-HSA-422475
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 in Cancer R-HSA-2644603
NRIF signals cell death from the nucleus R-HSA-205043
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
p75 NTR receptor-mediated signalling R-HSA-193704
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH R-HSA-157118
Regulated proteolysis of p75NTR R-HSA-193692
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
EPH-Ephrin signaling R-HSA-2682334
Nervous system development R-HSA-9675108
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nuclear signaling by ERBB4 R-HSA-1251985
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH3 R-HSA-9012852
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH2 R-HSA-1980145
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Death Receptor Signaling R-HSA-73887
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Signaling by NOTCH R-HSA-157118
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH3 R-HSA-9012852
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Death Receptor Signaling R-HSA-73887
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Regulated proteolysis of p75NTR R-HSA-193692
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH4 R-HSA-9013694
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH2 R-HSA-1980145
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH1 R-HSA-1980143
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Nervous system development R-HSA-9675108
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
EPH-Ephrin signaling R-HSA-2682334
Nuclear signaling by ERBB4 R-HSA-1251985
Nuclear signaling by ERBB4 R-HSA-1251985
Metabolism of proteins R-HSA-392499
Signal Transduction R-HSA-162582
Death Receptor Signaling R-HSA-73887
Signaling by ERBB4 R-HSA-1236394
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH4 R-HSA-9013694
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nervous system development R-HSA-9675108
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Amyloid fiber formation R-HSA-977225
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH2 R-HSA-1980145
Axon guidance R-HSA-422475
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-Ephrin signaling R-HSA-2682334
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signal Transduction R-HSA-162582
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH R-HSA-157118
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH2 R-HSA-1980145
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH3 R-HSA-9012852
Noncanonical activation of NOTCH3 R-HSA-9017802
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Nervous system development R-HSA-9675108
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Death Receptor Signaling R-HSA-73887
EPH-Ephrin signaling R-HSA-2682334
Metabolism of proteins R-HSA-392499
Nuclear signaling by ERBB4 R-HSA-1251985
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Axon guidance R-HSA-422475
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NRIF signals cell death from the nucleus R-HSA-205043
Death Receptor Signaling R-HSA-73887
Disease R-HSA-1643685
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Amyloid fiber formation R-HSA-977225
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 in Cancer R-HSA-2644603
Axon guidance R-HSA-422475
Nervous system development R-HSA-9675108
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signal Transduction R-HSA-162582
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
Metabolism of proteins R-HSA-392499
Signaling by NOTCH2 R-HSA-1980145
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 R-HSA-1980143
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Developmental Biology R-HSA-1266738
Noncanonical activation of NOTCH3 R-HSA-9017802
Nervous system development R-HSA-9675108
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Regulated proteolysis of p75NTR R-HSA-193692
Signal Transduction R-HSA-162582
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-Ephrin signaling R-HSA-2682334
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH3 R-HSA-9012852
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH R-HSA-157118
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nuclear signaling by ERBB4 R-HSA-1251985
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH1 in Cancer R-HSA-2644603
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Death Receptor Signaling R-HSA-73887
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 R-HSA-1980143
Amyloid fiber formation R-HSA-977225
Disease R-HSA-1643685
Signaling by NOTCH2 R-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH3 R-HSA-9012852
Nervous system development R-HSA-9675108
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by ERBB4 R-HSA-1236394
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH4 R-HSA-9013694
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NRIF signals cell death from the nucleus R-HSA-205043
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-Ephrin signaling R-HSA-2682334
Axon guidance R-HSA-422475
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Signaling by ERBB4 R-HSA-1236394
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
Axon guidance R-HSA-422475
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 in Cancer R-HSA-2644603
EPH-Ephrin signaling R-HSA-2682334
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
Disease R-HSA-1643685
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Nervous system development R-HSA-9675108
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Amyloid fiber formation R-HSA-977225

Expression Atlas ENSG00000205155
LRG display in Ensembl gene LRG_222
NCBI gene (formerly Entrezgene) 55851
GeneCards 30100
HGNC Symbol HGNC:30100
MIM gene 607632
MIM morbid 613736
UniProtKB Gene Name Q9NZ42
WikiGene 55851
Gene: APH1A
Ensembl ID : ENSG00000117362
Description: aph-1 homolog A, gamma-secretase subunit
Gene Synonyms: APH-1A,CGI-78
5 APIs:
138 Possible Orthologues:

Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 in Cancer R-HSA-2644603
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH2 R-HSA-1980145
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
Nuclear signaling by ERBB4 R-HSA-1251985
Amyloid fiber formation R-HSA-977225
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH3 R-HSA-9012852
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism of proteins R-HSA-392499
Developmental Biology R-HSA-1266738
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Amyloid fiber formation R-HSA-977225
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 in Cancer R-HSA-2644603
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
Signaling by NOTCH1 R-HSA-1980143
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH3 R-HSA-9012852
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH4 R-HSA-9013694
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
p75 NTR receptor-mediated signalling R-HSA-193704
Death Receptor Signaling R-HSA-73887
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
Regulated proteolysis of p75NTR R-HSA-193692
Nuclear signaling by ERBB4 R-HSA-1251985
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH3 R-HSA-9012852
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nervous system development R-HSA-9675108
Signaling by NOTCH4 R-HSA-9013694
Axon guidance R-HSA-422475
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
Amyloid fiber formation R-HSA-977225
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 R-HSA-1980143
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Regulated proteolysis of p75NTR R-HSA-193692
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH1 in Cancer R-HSA-2644603
EPH-ephrin mediated repulsion of cells R-HSA-3928665
p75 NTR receptor-mediated signalling R-HSA-193704
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
Metabolism of proteins R-HSA-392499
Nervous system development R-HSA-9675108
Signaling by NOTCH2 R-HSA-1980145
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Developmental Biology R-HSA-1266738
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Regulated proteolysis of p75NTR R-HSA-193692
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
Axon guidance R-HSA-422475
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by ERBB4 R-HSA-1236394
Noncanonical activation of NOTCH3 R-HSA-9017802
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-Ephrin signaling R-HSA-2682334
Metabolism of proteins R-HSA-392499
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Regulated proteolysis of p75NTR R-HSA-193692
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH2 R-HSA-1980145
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nervous system development R-HSA-9675108
Death Receptor Signaling R-HSA-73887
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by ERBB4 R-HSA-1236394
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Developmental Biology R-HSA-1266738
Noncanonical activation of NOTCH3 R-HSA-9017802
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by ERBB4 R-HSA-1236394
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH4 R-HSA-9013694
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 R-HSA-1980143
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH3 R-HSA-9012852
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH R-HSA-157118
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Death Receptor Signaling R-HSA-73887
Amyloid fiber formation R-HSA-977225
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Metabolism of proteins R-HSA-392499
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 R-HSA-1980143
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH3 R-HSA-9012852
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH2 R-HSA-1980145
NRIF signals cell death from the nucleus R-HSA-205043
Signal Transduction R-HSA-162582
Regulated proteolysis of p75NTR R-HSA-193692
Nuclear signaling by ERBB4 R-HSA-1251985
Disease R-HSA-1643685
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Noncanonical activation of NOTCH3 R-HSA-9017802
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Axon guidance R-HSA-422475
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 in Cancer R-HSA-2644603
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Signal Transduction R-HSA-162582
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Nervous system development R-HSA-9675108
Metabolism of proteins R-HSA-392499
Regulated proteolysis of p75NTR R-HSA-193692
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH2 R-HSA-1980145
Developmental Biology R-HSA-1266738
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 R-HSA-1980143
Regulated proteolysis of p75NTR R-HSA-193692
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH2 R-HSA-1980145
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Metabolism of proteins R-HSA-392499
Signaling by ERBB4 R-HSA-1236394
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH4 R-HSA-9013694
Death Receptor Signaling R-HSA-73887
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
EPH-Ephrin signaling R-HSA-2682334
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Axon guidance R-HSA-422475
Signaling by NOTCH1 in Cancer R-HSA-2644603
Amyloid fiber formation R-HSA-977225
Developmental Biology R-HSA-1266738
EPH-Ephrin signaling R-HSA-2682334
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH2 R-HSA-1980145
Signal Transduction R-HSA-162582
Death Receptor Signaling R-HSA-73887
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
Metabolism of proteins R-HSA-392499
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Amyloid fiber formation R-HSA-977225
Nervous system development R-HSA-9675108
Metabolism of proteins R-HSA-392499
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
EPH-Ephrin signaling R-HSA-2682334
Disease R-HSA-1643685
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH2 R-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Axon guidance R-HSA-422475
Death Receptor Signaling R-HSA-73887

Expression Atlas ENSG00000117362
NCBI gene (formerly Entrezgene) 51107
GeneCards 29509
HGNC Symbol HGNC:29509
MIM gene 607629
UniProtKB Gene Name Q96BI3
WikiGene 51107
Gene: PSEN2
Ensembl ID : ENSG00000143801
Description: presenilin 2
Gene Synonyms: AD3L,AD4,E5-1,PS-2,PS2,STM2
5 APIs:
205 Possible Orthologues:

NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH4 R-HSA-9013694
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Nervous system development R-HSA-9675108
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH3 R-HSA-9012852
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Nuclear signaling by ERBB4 R-HSA-1251985
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by ERBB4 R-HSA-1236394
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
EPH-Ephrin signaling R-HSA-2682334
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signal Transduction R-HSA-162582
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Axon guidance R-HSA-422475
Signaling by NOTCH3 R-HSA-9012852
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH2 R-HSA-1980145
p75 NTR receptor-mediated signalling R-HSA-193704
Death Receptor Signaling R-HSA-73887
EPH-Ephrin signaling R-HSA-2682334
Noncanonical activation of NOTCH3 R-HSA-9017802
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Developmental Biology R-HSA-1266738
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NRIF signals cell death from the nucleus R-HSA-205043
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH4 R-HSA-9013694
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH2 R-HSA-1980145
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Noncanonical activation of NOTCH3 R-HSA-9017802
Axon guidance R-HSA-422475
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
NRIF signals cell death from the nucleus R-HSA-205043
Disease R-HSA-1643685
Nervous system development R-HSA-9675108
Death Receptor Signaling R-HSA-73887
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Developmental Biology R-HSA-1266738
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 in Cancer R-HSA-2644603
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
p75 NTR receptor-mediated signalling R-HSA-193704
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
Regulated proteolysis of p75NTR R-HSA-193692
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Axon guidance R-HSA-422475
Signaling by ERBB4 R-HSA-1236394
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH2 R-HSA-1980145
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
Nuclear signaling by ERBB4 R-HSA-1251985
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Disease R-HSA-1643685
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Noncanonical activation of NOTCH3 R-HSA-9017802
p75 NTR receptor-mediated signalling R-HSA-193704
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH2 R-HSA-1980145
Signal Transduction R-HSA-162582
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Noncanonical activation of NOTCH3 R-HSA-9017802
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH4 R-HSA-9013694
Signal Transduction R-HSA-162582
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Axon guidance R-HSA-422475
Nervous system development R-HSA-9675108
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Developmental Biology R-HSA-1266738
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nuclear signaling by ERBB4 R-HSA-1251985
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-Ephrin signaling R-HSA-2682334
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603
Noncanonical activation of NOTCH3 R-HSA-9017802
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH3 R-HSA-9012852
Nervous system development R-HSA-9675108
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Death Receptor Signaling R-HSA-73887
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by ERBB4 R-HSA-1236394
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nervous system development R-HSA-9675108
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Axon guidance R-HSA-422475
Signaling by NOTCH3 R-HSA-9012852
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH2 R-HSA-1980145
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Developmental Biology R-HSA-1266738
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nuclear signaling by ERBB4 R-HSA-1251985
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 in Cancer R-HSA-2644603
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Disease R-HSA-1643685
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by ERBB4 R-HSA-1236394
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH4 R-HSA-9013694
Nuclear signaling by ERBB4 R-HSA-1251985
Death Receptor Signaling R-HSA-73887
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096

Expression Atlas ENSG00000143801
LRG display in Ensembl gene LRG_225
NCBI gene (formerly Entrezgene) 5664
GeneCards 9509
HGNC Symbol HGNC:9509
MIM gene 600759
MIM morbid 613697
UniProtKB Gene Name P49810
WikiGene 5664
Gene: MTOR
Ensembl ID : ENSG00000198793
Description: mechanistic target of rapamycin kinase
Gene Synonyms: FLJ44809,FRAP,FRAP1,FRAP2,RAFT1,RAPT1
26 APIs:
224 Possible Orthologues:

Costimulation by the CD28 family R-HSA-388841
MTOR signalling R-HSA-165159
Costimulation by the CD28 family R-HSA-388841
HSF1-dependent transactivation R-HSA-3371571
Signal Transduction R-HSA-162582
Autophagy R-HSA-9612973
Cellular response to starvation R-HSA-9711097
Cellular responses to stimuli R-HSA-8953897
RNA Polymerase II Transcription R-HSA-73857
PIP3 activates AKT signaling R-HSA-1257604
Macroautophagy R-HSA-1632852
Generic Transcription Pathway R-HSA-212436
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
MTOR signalling R-HSA-165159
TP53 Regulates Metabolic Genes R-HSA-5628897
Gene expression (Transcription) R-HSA-74160
VEGFR2 mediated vascular permeability R-HSA-5218920
VEGFA-VEGFR2 Pathway R-HSA-4420097
PTEN Regulation R-HSA-6807070
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K/AKT Signaling in Cancer R-HSA-2219528
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular response to heat stress R-HSA-3371556
Regulation of TP53 Degradation R-HSA-6804757
Regulation of PTEN gene transcription R-HSA-8943724
Immune System R-HSA-168256
Regulation of TP53 Expression and Degradation R-HSA-6806003
Signaling by VEGF R-HSA-194138
Adaptive Immune System R-HSA-1280218
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cellular responses to stress R-HSA-2262752
mTORC1-mediated signalling R-HSA-166208
Amino acids regulate mTORC1 R-HSA-9639288
CD28 co-stimulation R-HSA-389356
Transcriptional Regulation by TP53 R-HSA-3700989
Disease R-HSA-1643685
Intracellular signaling by second messengers R-HSA-9006925
CD28 dependent PI3K/Akt signaling R-HSA-389357
Regulation of TP53 Activity R-HSA-5633007
Adaptive Immune System R-HSA-1280218
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
Transcriptional Regulation by TP53 R-HSA-3700989
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Regulation of TP53 Degradation R-HSA-6804757
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
MTOR signalling R-HSA-165159
Macroautophagy R-HSA-1632852
Amino acids regulate mTORC1 R-HSA-9639288
Signal Transduction R-HSA-162582
CD28 co-stimulation R-HSA-389356
VEGFR2 mediated vascular permeability R-HSA-5218920
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
HSF1-dependent transactivation R-HSA-3371571
Autophagy R-HSA-9612973
Cellular responses to stress R-HSA-2262752
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by VEGF R-HSA-194138
TP53 Regulates Metabolic Genes R-HSA-5628897
CD28 dependent PI3K/Akt signaling R-HSA-389357
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
VEGFA-VEGFR2 Pathway R-HSA-4420097
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Expression and Degradation R-HSA-6806003
Costimulation by the CD28 family R-HSA-388841
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PTEN Regulation R-HSA-6807070
mTORC1-mediated signalling R-HSA-166208
Generic Transcription Pathway R-HSA-212436
Cellular response to heat stress R-HSA-3371556
Immune System R-HSA-168256
Intracellular signaling by second messengers R-HSA-9006925
Cellular response to starvation R-HSA-9711097
Cellular response to heat stress R-HSA-3371556
CD28 dependent PI3K/Akt signaling R-HSA-389357
PIP3 activates AKT signaling R-HSA-1257604
Transcriptional Regulation by TP53 R-HSA-3700989
Autophagy R-HSA-9612973
VEGFR2 mediated vascular permeability R-HSA-5218920
Regulation of PTEN gene transcription R-HSA-8943724
Immune System R-HSA-168256
MTOR signalling R-HSA-165159
Signaling by VEGF R-HSA-194138
VEGFA-VEGFR2 Pathway R-HSA-4420097
Cellular responses to stimuli R-HSA-8953897
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
HSF1-dependent transactivation R-HSA-3371571
Cellular response to starvation R-HSA-9711097
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Regulation of TP53 Expression and Degradation R-HSA-6806003
Regulation of TP53 Activity R-HSA-5633007
TP53 Regulates Metabolic Genes R-HSA-5628897
Signal Transduction R-HSA-162582
Regulation of TP53 Degradation R-HSA-6804757
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Disease R-HSA-1643685
Costimulation by the CD28 family R-HSA-388841
Gene expression (Transcription) R-HSA-74160
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
mTORC1-mediated signalling R-HSA-166208
Amino acids regulate mTORC1 R-HSA-9639288
Adaptive Immune System R-HSA-1280218
Macroautophagy R-HSA-1632852
PTEN Regulation R-HSA-6807070
CD28 co-stimulation R-HSA-389356
Cellular responses to stress R-HSA-2262752
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RNA Polymerase II Transcription R-HSA-73857
Regulation of PTEN gene transcription R-HSA-8943724
Costimulation by the CD28 family R-HSA-388841
Intracellular signaling by second messengers R-HSA-9006925
Immune System R-HSA-168256
RNA Polymerase II Transcription R-HSA-73857
Signaling by VEGF R-HSA-194138
PIP3 activates AKT signaling R-HSA-1257604
CD28 co-stimulation R-HSA-389356
Autophagy R-HSA-9612973
Signal Transduction R-HSA-162582
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Generic Transcription Pathway R-HSA-212436
HSF1-dependent transactivation R-HSA-3371571
mTORC1-mediated signalling R-HSA-166208
Macroautophagy R-HSA-1632852
Adaptive Immune System R-HSA-1280218
Cellular response to starvation R-HSA-9711097
PTEN Regulation R-HSA-6807070
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
CD28 dependent PI3K/Akt signaling R-HSA-389357
Gene expression (Transcription) R-HSA-74160
TP53 Regulates Metabolic Genes R-HSA-5628897
VEGFR2 mediated vascular permeability R-HSA-5218920
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFA-VEGFR2 Pathway R-HSA-4420097
Regulation of TP53 Degradation R-HSA-6804757
PI3K/AKT Signaling in Cancer R-HSA-2219528
Disease R-HSA-1643685
Transcriptional Regulation by TP53 R-HSA-3700989
MTOR signalling R-HSA-165159
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Expression and Degradation R-HSA-6806003
Amino acids regulate mTORC1 R-HSA-9639288
Cellular responses to stimuli R-HSA-8953897
Cellular response to heat stress R-HSA-3371556
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Expression and Degradation R-HSA-6806003
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular responses to stimuli R-HSA-8953897
Cellular response to starvation R-HSA-9711097
Transcriptional Regulation by TP53 R-HSA-3700989
TP53 Regulates Metabolic Genes R-HSA-5628897
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
MTOR signalling R-HSA-165159
CD28 dependent PI3K/Akt signaling R-HSA-389357
PIP3 activates AKT signaling R-HSA-1257604
mTORC1-mediated signalling R-HSA-166208
VEGFA-VEGFR2 Pathway R-HSA-4420097
CD28 co-stimulation R-HSA-389356
Macroautophagy R-HSA-1632852
Autophagy R-HSA-9612973
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Regulation of TP53 Activity R-HSA-5633007
Regulation of TP53 Degradation R-HSA-6804757
HSF1-dependent transactivation R-HSA-3371571
PTEN Regulation R-HSA-6807070
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Generic Transcription Pathway R-HSA-212436
Disease R-HSA-1643685
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cellular responses to stress R-HSA-2262752
Gene expression (Transcription) R-HSA-74160
Intracellular signaling by second messengers R-HSA-9006925
Amino acids regulate mTORC1 R-HSA-9639288
Signaling by VEGF R-HSA-194138
Cellular response to heat stress R-HSA-3371556
VEGFR2 mediated vascular permeability R-HSA-5218920
Signal Transduction R-HSA-162582
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Degradation R-HSA-6804757
mTORC1-mediated signalling R-HSA-166208
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFA-VEGFR2 Pathway R-HSA-4420097
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TP53 Regulates Metabolic Genes R-HSA-5628897
MTOR signalling R-HSA-165159
CD28 co-stimulation R-HSA-389356
VEGFR2 mediated vascular permeability R-HSA-5218920
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PTEN Regulation R-HSA-6807070
Adaptive Immune System R-HSA-1280218
Regulation of TP53 Activity R-HSA-5633007
Intracellular signaling by second messengers R-HSA-9006925
Costimulation by the CD28 family R-HSA-388841
HSF1-dependent transactivation R-HSA-3371571
Amino acids regulate mTORC1 R-HSA-9639288
Transcriptional Regulation by TP53 R-HSA-3700989
PIP3 activates AKT signaling R-HSA-1257604
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Expression and Degradation R-HSA-6806003
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cellular responses to stress R-HSA-2262752
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Gene expression (Transcription) R-HSA-74160
Cellular response to starvation R-HSA-9711097
Disease R-HSA-1643685
Cellular response to heat stress R-HSA-3371556
CD28 dependent PI3K/Akt signaling R-HSA-389357
Immune System R-HSA-168256
Autophagy R-HSA-9612973
Signaling by VEGF R-HSA-194138
Macroautophagy R-HSA-1632852
VEGFA-VEGFR2 Pathway R-HSA-4420097
PIP3 activates AKT signaling R-HSA-1257604
Costimulation by the CD28 family R-HSA-388841
Intracellular signaling by second messengers R-HSA-9006925
Cellular responses to stimuli R-HSA-8953897
HSF1-dependent transactivation R-HSA-3371571
Regulation of PTEN gene transcription R-HSA-8943724
Signal Transduction R-HSA-162582
mTORC1-mediated signalling R-HSA-166208
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by VEGF R-HSA-194138
Transcriptional Regulation by TP53 R-HSA-3700989
Adaptive Immune System R-HSA-1280218
Macroautophagy R-HSA-1632852
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Cellular response to starvation R-HSA-9711097
PTEN Regulation R-HSA-6807070
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular response to heat stress R-HSA-3371556
Regulation of TP53 Degradation R-HSA-6804757
Immune System R-HSA-168256
Autophagy R-HSA-9612973
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Activity R-HSA-5633007
CD28 co-stimulation R-HSA-389356
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
TP53 Regulates Metabolic Genes R-HSA-5628897
Amino acids regulate mTORC1 R-HSA-9639288
Regulation of TP53 Expression and Degradation R-HSA-6806003
PI3K/AKT Signaling in Cancer R-HSA-2219528
VEGFR2 mediated vascular permeability R-HSA-5218920
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stress R-HSA-2262752
HSF1-dependent transactivation R-HSA-3371571
PI3K/AKT Signaling in Cancer R-HSA-2219528
TP53 Regulates Metabolic Genes R-HSA-5628897
Cellular responses to stress R-HSA-2262752
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
PIP3 activates AKT signaling R-HSA-1257604
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFA-VEGFR2 Pathway R-HSA-4420097
Autophagy R-HSA-9612973
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
Regulation of PTEN gene transcription R-HSA-8943724
CD28 dependent PI3K/Akt signaling R-HSA-389357
RNA Polymerase II Transcription R-HSA-73857
Costimulation by the CD28 family R-HSA-388841
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
CD28 co-stimulation R-HSA-389356
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cellular response to starvation R-HSA-9711097
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
Macroautophagy R-HSA-1632852
MTOR signalling R-HSA-165159
Regulation of TP53 Expression and Degradation R-HSA-6806003
Gene expression (Transcription) R-HSA-74160
PTEN Regulation R-HSA-6807070
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Intracellular signaling by second messengers R-HSA-9006925
VEGFR2 mediated vascular permeability R-HSA-5218920
Cellular response to heat stress R-HSA-3371556
Amino acids regulate mTORC1 R-HSA-9639288
Signaling by VEGF R-HSA-194138
Regulation of TP53 Degradation R-HSA-6804757
mTORC1-mediated signalling R-HSA-166208
Cellular response to heat stress R-HSA-3371556
TP53 Regulates Metabolic Genes R-HSA-5628897
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
HSF1-dependent transactivation R-HSA-3371571
Costimulation by the CD28 family R-HSA-388841
Adaptive Immune System R-HSA-1280218
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Regulation of TP53 Degradation R-HSA-6804757
Cellular responses to stimuli R-HSA-8953897
mTORC1-mediated signalling R-HSA-166208
Signaling by VEGF R-HSA-194138
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Amino acids regulate mTORC1 R-HSA-9639288
Autophagy R-HSA-9612973
Regulation of PTEN gene transcription R-HSA-8943724
PTEN Regulation R-HSA-6807070
CD28 co-stimulation R-HSA-389356
Regulation of TP53 Expression and Degradation R-HSA-6806003
VEGFA-VEGFR2 Pathway R-HSA-4420097
Cellular responses to stress R-HSA-2262752
Signal Transduction R-HSA-162582
Macroautophagy R-HSA-1632852
MTOR signalling R-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
VEGFR2 mediated vascular permeability R-HSA-5218920
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
PIP3 activates AKT signaling R-HSA-1257604
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cellular response to starvation R-HSA-9711097
Regulation of TP53 Activity R-HSA-5633007
Immune System R-HSA-168256
Transcriptional Regulation by TP53 R-HSA-3700989
VEGFA-VEGFR2 Pathway R-HSA-4420097
Adaptive Immune System R-HSA-1280218
HSF1-dependent transactivation R-HSA-3371571
Immune System R-HSA-168256
RNA Polymerase II Transcription R-HSA-73857
Regulation of TP53 Activity R-HSA-5633007
Costimulation by the CD28 family R-HSA-388841
PTEN Regulation R-HSA-6807070
CD28 co-stimulation R-HSA-389356
Intracellular signaling by second messengers R-HSA-9006925
Cellular responses to stimuli R-HSA-8953897
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Gene expression (Transcription) R-HSA-74160
VEGFR2 mediated vascular permeability R-HSA-5218920
Cellular responses to stress R-HSA-2262752
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Degradation R-HSA-6804757
MTOR signalling R-HSA-165159
Signaling by VEGF R-HSA-194138
Macroautophagy R-HSA-1632852
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Expression and Degradation R-HSA-6806003
CD28 dependent PI3K/Akt signaling R-HSA-389357
Cellular response to heat stress R-HSA-3371556
Amino acids regulate mTORC1 R-HSA-9639288
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
Autophagy R-HSA-9612973
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
mTORC1-mediated signalling R-HSA-166208
Signal Transduction R-HSA-162582
Cellular response to starvation R-HSA-9711097
TP53 Regulates Metabolic Genes R-HSA-5628897
PI3K/AKT Signaling in Cancer R-HSA-2219528
Regulation of TP53 Activity R-HSA-5633007
RNA Polymerase II Transcription R-HSA-73857
Autophagy R-HSA-9612973
HSF1-dependent transactivation R-HSA-3371571
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cellular responses to stress R-HSA-2262752
CD28 dependent PI3K/Akt signaling R-HSA-389357
PI3K/AKT Signaling in Cancer R-HSA-2219528
Gene expression (Transcription) R-HSA-74160
Disease R-HSA-1643685
VEGFA-VEGFR2 Pathway R-HSA-4420097
Regulation of TP53 Degradation R-HSA-6804757
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cellular response to starvation R-HSA-9711097
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular responses to stimuli R-HSA-8953897
Signaling by VEGF R-HSA-194138
Adaptive Immune System R-HSA-1280218
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
Regulation of PTEN gene transcription R-HSA-8943724
PIP3 activates AKT signaling R-HSA-1257604
Transcriptional Regulation by TP53 R-HSA-3700989
Cellular response to heat stress R-HSA-3371556
TP53 Regulates Metabolic Genes R-HSA-5628897
VEGFR2 mediated vascular permeability R-HSA-5218920
Generic Transcription Pathway R-HSA-212436
MTOR signalling R-HSA-165159
CD28 co-stimulation R-HSA-389356
mTORC1-mediated signalling R-HSA-166208
Costimulation by the CD28 family R-HSA-388841
Immune System R-HSA-168256
Macroautophagy R-HSA-1632852
Amino acids regulate mTORC1 R-HSA-9639288
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
PTEN Regulation R-HSA-6807070

Expression Atlas ENSG00000198793
LRG display in Ensembl gene LRG_734
NCBI gene (formerly Entrezgene) 2475
GeneCards 3942
HGNC Symbol HGNC:3942
MIM gene 601231
MIM morbid 616638
UniProtKB Gene Name P42345
WikiGene 2475
Gene: CHEK1
Ensembl ID : ENSG00000149554
Description: checkpoint kinase 1
Gene Synonyms: CHK1
10 APIs:
179 Possible Orthologues:

Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) R-HSA-5685942
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of TP53 Activity R-HSA-5633007
Signaling by SCF-KIT R-HSA-1433557
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G2/M Checkpoints R-HSA-69481
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
G1/S DNA Damage Checkpoints R-HSA-69615
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Homology Directed Repair R-HSA-5693538
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cell Cycle R-HSA-1640170
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) R-HSA-5685942
G2/M DNA damage checkpoint R-HSA-69473
DNA Double-Strand Break Repair R-HSA-5693532
Processing of DNA double-strand break ends R-HSA-5693607
G2/M Checkpoints R-HSA-69481
Transcriptional Regulation by E2F6 R-HSA-8953750
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Homology Directed Repair R-HSA-5693538
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
p53-Independent DNA Damage Response R-HSA-69610
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
DNA Repair R-HSA-73894
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by SCF-KIT R-HSA-1433557
Activation of ATR in response to replication stress R-HSA-176187
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Gene expression (Transcription) R-HSA-74160
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
p53-Independent DNA Damage Response R-HSA-69610
Signaling by SCF-KIT R-HSA-1433557
G1/S DNA Damage Checkpoints R-HSA-69615
Processing of DNA double-strand break ends R-HSA-5693607
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Homology Directed Repair R-HSA-5693538
RNA Polymerase II Transcription R-HSA-73857
G2/M DNA damage checkpoint R-HSA-69473
HDR through Homologous Recombination (HRR) R-HSA-5685942
DNA Double-Strand Break Repair R-HSA-5693532
Signal Transduction R-HSA-162582
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M Checkpoints R-HSA-69481
DNA Repair R-HSA-73894
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of TP53 Activity R-HSA-5633007
Activation of ATR in response to replication stress R-HSA-176187
DNA Repair R-HSA-73894
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Activation of ATR in response to replication stress R-HSA-176187
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) R-HSA-5685942
Homology Directed Repair R-HSA-5693538
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M DNA damage checkpoint R-HSA-69473
DNA Double-Strand Break Repair R-HSA-5693532
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity R-HSA-5633007
Signaling by SCF-KIT R-HSA-1433557
G2/M Checkpoints R-HSA-69481
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Cell Cycle R-HSA-1640170
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle R-HSA-1640170
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Signal Transduction R-HSA-162582
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
G1/S DNA Damage Checkpoints R-HSA-69615
Cell Cycle Checkpoints R-HSA-69620
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
Homology Directed Repair R-HSA-5693538
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
Signaling by SCF-KIT R-HSA-1433557
Activation of ATR in response to replication stress R-HSA-176187
HDR through Homologous Recombination (HRR) R-HSA-5685942
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity R-HSA-5633007
Gene expression (Transcription) R-HSA-74160
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
G2/M Checkpoints R-HSA-69481
p53-Independent DNA Damage Response R-HSA-69610
Signal Transduction R-HSA-162582
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle R-HSA-1640170
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by SCF-KIT R-HSA-1433557
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Processing of DNA double-strand break ends R-HSA-5693607
DNA Repair R-HSA-73894
Activation of ATR in response to replication stress R-HSA-176187
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Generic Transcription Pathway R-HSA-212436
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) R-HSA-5685942
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G1/S DNA Damage Checkpoints R-HSA-69615
G2/M Checkpoints R-HSA-69481
Gene expression (Transcription) R-HSA-74160
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
Processing of DNA double-strand break ends R-HSA-5693607
Transcriptional Regulation by E2F6 R-HSA-8953750
DNA Repair R-HSA-73894
Cell Cycle Checkpoints R-HSA-69620
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
Generic Transcription Pathway R-HSA-212436
p53-Independent DNA Damage Response R-HSA-69610
HDR through Homologous Recombination (HRR) R-HSA-5685942
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
G1/S DNA Damage Checkpoints R-HSA-69615
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity R-HSA-5633007
G2/M DNA damage checkpoint R-HSA-69473
Signaling by SCF-KIT R-HSA-1433557
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homology Directed Repair R-HSA-5693538
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cell Cycle R-HSA-1640170
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by SCF-KIT R-HSA-1433557
Transcriptional Regulation by TP53 R-HSA-3700989
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Transcriptional Regulation by E2F6 R-HSA-8953750
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Processing of DNA double-strand break ends R-HSA-5693607
Activation of ATR in response to replication stress R-HSA-176187
HDR through Homologous Recombination (HRR) R-HSA-5685942
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of TP53 Activity R-HSA-5633007
DNA Repair R-HSA-73894
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
Generic Transcription Pathway R-HSA-212436
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
DNA Double-Strand Break Repair R-HSA-5693532
G1/S DNA Damage Checkpoints R-HSA-69615
Signal Transduction R-HSA-162582
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Gene expression (Transcription) R-HSA-74160
DNA Repair R-HSA-73894
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Signaling by SCF-KIT R-HSA-1433557
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
HDR through Homologous Recombination (HRR) R-HSA-5685942
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G2/M DNA damage checkpoint R-HSA-69473
Activation of ATR in response to replication stress R-HSA-176187
Regulation of TP53 Activity R-HSA-5633007
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Transcriptional Regulation by E2F6 R-HSA-8953750
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
Generic Transcription Pathway R-HSA-212436
G1/S DNA Damage Checkpoints R-HSA-69615
DNA Double-Strand Break Repair R-HSA-5693532
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Cell Cycle Checkpoints R-HSA-69620
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Signal Transduction R-HSA-162582
Activation of ATR in response to replication stress R-HSA-176187
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of TP53 Activity R-HSA-5633007
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by SCF-KIT R-HSA-1433557
Transcriptional Regulation by TP53 R-HSA-3700989
Transcriptional Regulation by E2F6 R-HSA-8953750
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
DNA Repair R-HSA-73894
Processing of DNA double-strand break ends R-HSA-5693607
Homology Directed Repair R-HSA-5693538
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity R-HSA-5633007
Processing of DNA double-strand break ends R-HSA-5693607
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Cell Cycle R-HSA-1640170
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
G2/M DNA damage checkpoint R-HSA-69473
Signaling by SCF-KIT R-HSA-1433557
DNA Double-Strand Break Repair R-HSA-5693532
p53-Independent DNA Damage Response R-HSA-69610
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Transcriptional Regulation by E2F6 R-HSA-8953750
HDR through Homologous Recombination (HRR) R-HSA-5685942
Activation of ATR in response to replication stress R-HSA-176187
Signal Transduction R-HSA-162582
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Homology Directed Repair R-HSA-5693538
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G1/S DNA Damage Checkpoints R-HSA-69615

Expression Atlas ENSG00000149554
NCBI gene (formerly Entrezgene) 1111
GeneCards 1925
HGNC Symbol HGNC:1925
MIM gene 603078
UniProtKB Gene Name O14757
WikiGene 1111
Ensembl ID : ENSG00000089022
Description: MAPK activated protein kinase 5
Gene Synonyms: MK5,PRAK
1 APIs:
179 Possible Orthologues:

Signal Transduction R-HSA-162582
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
MAPK6/MAPK4 signaling R-HSA-5687128
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
MAPK family signaling cascades R-HSA-5683057
Cellular Senescence R-HSA-2559583
Signal Transduction R-HSA-162582
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
Oxidative Stress Induced Senescence R-HSA-2559580
MAPK6/MAPK4 signaling R-HSA-5687128
MAPK6/MAPK4 signaling R-HSA-5687128
Oxidative Stress Induced Senescence R-HSA-2559580
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
MAPK family signaling cascades R-HSA-5683057
Cellular responses to stimuli R-HSA-8953897
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular Senescence R-HSA-2559583
Regulation of TP53 Activity R-HSA-5633007
Regulation of TP53 Activity R-HSA-5633007
MAPK6/MAPK4 signaling R-HSA-5687128
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular responses to stress R-HSA-2262752
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Cellular responses to stimuli R-HSA-8953897
Signal Transduction R-HSA-162582
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Cellular Senescence R-HSA-2559583
RNA Polymerase II Transcription R-HSA-73857
Regulation of TP53 Activity R-HSA-5633007
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
MAPK6/MAPK4 signaling R-HSA-5687128
Signal Transduction R-HSA-162582
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
MAPK family signaling cascades R-HSA-5683057
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Generic Transcription Pathway R-HSA-212436
Cellular Senescence R-HSA-2559583
MAPK6/MAPK4 signaling R-HSA-5687128
Regulation of TP53 Activity R-HSA-5633007
MAPK family signaling cascades R-HSA-5683057
Transcriptional Regulation by TP53 R-HSA-3700989
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cellular responses to stimuli R-HSA-8953897
MAPK6/MAPK4 signaling R-HSA-5687128
Oxidative Stress Induced Senescence R-HSA-2559580
Transcriptional Regulation by TP53 R-HSA-3700989
MAPK family signaling cascades R-HSA-5683057
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular Senescence R-HSA-2559583
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stimuli R-HSA-8953897
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
MAPK6/MAPK4 signaling R-HSA-5687128
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Gene expression (Transcription) R-HSA-74160
Oxidative Stress Induced Senescence R-HSA-2559580
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
MAPK family signaling cascades R-HSA-5683057
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Gene expression (Transcription) R-HSA-74160
MAPK6/MAPK4 signaling R-HSA-5687128
Regulation of TP53 Activity R-HSA-5633007
Generic Transcription Pathway R-HSA-212436
MAPK family signaling cascades R-HSA-5683057
Oxidative Stress Induced Senescence R-HSA-2559580
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular responses to stimuli R-HSA-8953897
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cellular Senescence R-HSA-2559583
Gene expression (Transcription) R-HSA-74160
MAPK6/MAPK4 signaling R-HSA-5687128
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Regulation of TP53 Activity R-HSA-5633007
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583

Expression Atlas ENSG00000089022
NCBI gene (formerly Entrezgene) 8550
GeneCards 6889
HGNC Symbol HGNC:6889
MIM gene 606723
MIM morbid 619869
UniProtKB Gene Name R4GN93
WikiGene 8550