ZATOLMILAST

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Search structure


Synonyms	BPN-14770 BPN14770 Bpn-14770 Bpn14770 Zatolmilast
Status
Molecule Category	Free-form
UNII	G786V328X6

Structure


InChI Key	LTSUMTMGJHPGFX-UHFFFAOYSA-N
Smiles	O=C(O)Cc1ccc(Cc2cc(-c3cccc(Cl)c3)nc(C(F)(F)F)c2)cc1
InChI	InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H15ClF3NO2
Molecular Weight	405.8
AlogP	5.64
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	50.19
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Phosphodiesterase 4D inhibitor	INHIBITOR	PubMed Other

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D	-	127	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	2.9-133	-	-	-

Target Conservation


Protein: Phosphodiesterase 4D Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4D Organism : Homo sapiens Q08499 ENSG00000113448

Cross References

Resources	Reference
ChEMBL	CHEMBL4541964
FDA SRS	G786V328X6
Guide to Pharmacology	10451
PDB	KR7
SureChEMBL	SCHEMBL15660260

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025