OLMESARTAN MEDOXOMIL

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Synonyms
Status
Molecule Category Free-form
ATC C09CA08
UNII 6M97XTV3HD
EPA CompTox DTXSID9045924

Structure

InChI Key UQGKUQLKSCSZGY-UHFFFAOYSA-N
Smiles CCCc1nc(C(C)(C)O)c(C(=O)OCc2oc(=O)oc2C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
InChI
InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H30N6O6
Molecular Weight 558.6
AlogP 4.17
Hydrogen Bond Acceptor 11.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 162.16
Molecular species ACID
Aromatic Rings 5.0
Heavy Atoms 41.0

Pharmacology

Mechanism of Action Action Reference
Type-1 angiotensin II receptor antagonist ANTAGONIST DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- 977.24-977.24 - 540-750 -7.9-60.4
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- 977.24-977.24 - 540-750 9.702-15.39
Homo sapiens
- - - - -7.9-60.4

Target Conservation

Protein: Type-1 angiotensin II receptor
Description: Type-1 angiotensin II receptor
Organism : Homo sapiens
P30556 ENSG00000144891

Cross References

Resources Reference
ChEBI 31932
ChEMBL CHEMBL1200692
DrugCentral 1985
FDA SRS 6M97XTV3HD
Guide to Pharmacology 591
PharmGKB PA164742950
SureChEMBL SCHEMBL16403
ZINC ZINC000004149248
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