GANAPLACIDE

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Search structure


Synonyms	GNF 156 GNF-156 Ganaplacide KAF 156 KAF-156 KAF156 Kaf156
Status
Molecule Category	Free-form
UNII	85VMN9JU7A

Structure


InChI Key	BUPRVECGWBHCQV-UHFFFAOYSA-N
Smiles	CC1(C)c2nc(-c3ccc(F)cc3)c(Nc3ccc(F)cc3)n2CCN1C(=O)CN
InChI	InChI=1S/C22H23F2N5O/c1-22(2)21-27-19(14-3-5-15(23)6-4-14)20(26-17-9-7-16(24)8-10-17)28(21)11-12-29(22)18(30)13-25/h3-10,26H,11-13,25H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H23F2N5O
Molecular Weight	411.46
AlogP	3.61
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	76.18
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	30.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	-	-	156	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	156	-
Plasmodium falciparum	6-12.6	11.1-108.4	-	-	-
Plasmodium falciparum Dd2	-	8.8	-	-	-
Plasmodium vivax	5.5	-	-	-	-

Cross References

Resources	Reference
ChEMBL	CHEMBL2058833
DrugBank	DB16173
FDA SRS	85VMN9JU7A
Guide to Pharmacology	9946
PubChem	49856296
SureChEMBL	SCHEMBL1047381

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025