NEVANIMIBE

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Search structure


Synonyms	Nevanimibe PD 132301 PD-132301
Status
Molecule Category	Free-form
UNII	VK9OS8R205

Structure


InChI Key	PKKNCEXEVUFFFI-UHFFFAOYSA-N
Smiles	CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(c2ccc(N(C)C)cc2)CCCC1
InChI	InChI=1S/C27H39N3O/c1-19(2)23-10-9-11-24(20(3)4)25(23)29-26(31)28-18-27(16-7-8-17-27)21-12-14-22(15-13-21)30(5)6/h9-15,19-20H,7-8,16-18H2,1-6H3,(H2,28,29,31)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C27H39N3O
Molecular Weight	421.63
AlogP	6.63
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	44.37
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	31.0

Pharmacology

Mechanism of Action	Action	Reference
Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme	-	37-52	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Oryctolagus cuniculus	-	37-52	-	-	-

Target Conservation


Protein: Acyl coenzyme A:cholesterol acyltransferase 1 Description: Sterol O-acyltransferase 1 Organism : Homo sapiens P35610 ENSG00000057252

Cross References

Resources	Reference
ChEMBL	CHEMBL46423
DrugBank	DB16254
FDA SRS	VK9OS8R205
PDB	ROV
PubChem	131679
SureChEMBL	SCHEMBL1119314

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025