CR-6086

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Search structure


Synonyms	CR6086 Cr 6086 Cr-6086 Cr6086
Status
Molecule Category	Free-form
UNII	SS2LQQ8094

Structure


InChI Key	CADWTPLFEZSAHM-UHFFFAOYSA-N
Smiles	O=C(O)c1ccc(C2(NC(=O)C3CC4(CCN3Cc3ccc(C(F)(F)F)cc3)CC4)CC2)cc1
InChI	InChI=1S/C26H27F3N2O3/c27-26(28,29)20-5-1-17(2-6-20)16-31-14-13-24(9-10-24)15-21(31)22(32)30-25(11-12-25)19-7-3-18(4-8-19)23(33)34/h1-8,21H,9-16H2,(H,30,32)(H,33,34)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C26H27F3N2O3
Molecular Weight	472.51
AlogP	4.95
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	69.64
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	34.0

Pharmacology

Mechanism of Action	Action	Reference
Prostanoid EP4 receptor antagonist	ANTAGONIST	Other PubMed

Target Conservation


Protein: Prostanoid EP4 receptor Description: Prostaglandin E2 receptor EP4 subtype Organism : Homo sapiens P35408 ENSG00000171522

Cross References

Resources	Reference
ChEMBL	CHEMBL3920982
DrugBank	DB16111
FDA SRS	SS2LQQ8094
PubChem	71186236
SureChEMBL	SCHEMBL14486354

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025