ROBALZOTAN

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Search structure


Synonyms	Azd-7371 NAD-299 Robalzotan
Status
Molecule Category	Free-form
UNII	I18M56OGME
EPA CompTox	DTXSID30168743

Structure


InChI Key	MQTUXRKNJYPMCG-CYBMUJFWSA-N
Smiles	NC(=O)c1ccc(F)c2c1C[C@@H](N(C1CCC1)C1CCC1)CO2
InChI	InChI=1S/C18H23FN2O2/c19-16-8-7-14(18(20)22)15-9-13(10-23-17(15)16)21(11-3-1-4-11)12-5-2-6-12/h7-8,11-13H,1-6,9-10H2,(H2,20,22)/t13-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H23FN2O2
Molecular Weight	318.39
AlogP	2.64
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	55.56
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin 1a (5-HT1a) receptor antagonist	ANTAGONIST	PubMed PubMed Wikipedia

Target Conservation


Protein: Serotonin 1a (5-HT1a) receptor Description: 5-hydroxytryptamine receptor 1A Organism : Homo sapiens P08908 ENSG00000178394

Cross References

Resources	Reference
ChEMBL	CHEMBL1628569
DrugBank	DB06538
FDA SRS	I18M56OGME
Guide to Pharmacology	72
PubChem	3055171
SureChEMBL	SCHEMBL115079
ZINC	ZINC000003811952

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025