ADOMEGLIVANT

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Search structure


Synonyms	Adomeglivant Adomeglivant, (-)- LY-2409021 LY2409021 Ly2409021
Status
Molecule Category	Free-form
UNII	74Z5ZL2KVG

Structure


InChI Key	FASLTMSUPQDLIB-MHZLTWQESA-N
Smiles	Cc1cc(O[C@@H](CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)cc(C)c1-c1ccc(C(C)(C)C)cc1
InChI	InChI=1S/C32H36F3NO4/c1-20-18-26(19-21(2)29(20)23-10-12-25(13-11-23)31(3,4)5)40-27(14-16-32(33,34)35)22-6-8-24(9-7-22)30(39)36-17-15-28(37)38/h6-13,18-19,27H,14-17H2,1-5H3,(H,36,39)(H,37,38)/t27-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C32H36F3NO4
Molecular Weight	555.64
AlogP	7.94
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	10.0
Polar Surface Area	75.63
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	40.0

Pharmacology

Mechanism of Action	Action	Reference
Glucagon receptor antagonist	ANTAGONIST	PubMed PubMed PubMed

Target Conservation


Protein: Glucagon receptor Description: Glucagon receptor Organism : Homo sapiens P47871 ENSG00000215644

Cross References

Resources	Reference
ChEMBL	CHEMBL3707351
DrugBank	DB11704
FDA SRS	74Z5ZL2KVG
Guide to Pharmacology	9479
PubChem	91933867
ZINC	ZINC000117040414

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025