EcoDrugPlus


Synonyms	Lomefloxacin Maxaquin Okacyn SC-47111A
Status
Molecule Category	Free-form
ATC	J01MA07 S01AE04
UNII	L6BR2WJD8V
EPA CompTox	DTXSID4040680


InChI Key	ZEKZLJVOYLTDKK-UHFFFAOYSA-N
Smiles	CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21
InChI	InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)

Property Name	Value
Molecular Formula	C17H19F2N3O3
Molecular Weight	351.35
AlogP	1.8
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	74.57
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	25.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Epigenetic regulator Writer Protein methyltransferase SET domain	-	-	-	-	14-23

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	14-23

Resources	Reference
ChEBI	116278
ChEMBL	CHEMBL561
DrugBank	DB00978
DrugCentral	1594
FDA SRS	L6BR2WJD8V
Human Metabolome Database	HMDB0015113
KEGG	C07078
PharmGKB	PA164749165
PubChem	3948
SureChEMBL	SCHEMBL34609

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

LOMEFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

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