ALCLOFENAC

/static/temp/default.svg

Search structure


Synonyms	Alclofenac Mervan W 7320
Status
Molecule Category	Free-form
ATC	M01AB06
UNII	M9CP5H21N8
EPA CompTox	DTXSID4020038

Structure


InChI Key	ARHWPKZXBHOEEE-UHFFFAOYSA-N
Smiles	C=CCOc1ccc(CC(=O)O)cc1Cl
InChI	InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C11H11ClO3
Molecular Weight	226.66
AlogP	2.53
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	46.53
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Mechanism of Action	Action	Reference
Cyclooxygenase-1 inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed PubMed

Target Conservation


Protein: Cyclooxygenase-1 Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303

Cross References

Resources	Reference
ChEBI	31183
ChEMBL	CHEMBL94081
DrugBank	DB13167
DrugCentral	107
FDA SRS	M9CP5H21N8
PubChem	30951
SureChEMBL	SCHEMBL25703
ZINC	ZINC000002014875

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025