SALICYLIC ACID

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Search structure


Synonyms	2-Hydroxy-benzoic acid Acnisal Advanced pain relief callus removers Advanced pain relief com removers Bazuka Clear away wart remover Compound v Compound w Cuplex verruca Dr. scholl's callus removers Dr. scholl's corn removers Dr. scholl's wart remover kit Duofilm Duofilm wart remover Duoplant
Status
Molecule Category	Free-form
ATC	D01AE12 S01BC08
UNII	O414PZ4LPZ
EPA CompTox	DTXSID7026368

Structure


InChI Key	YGSDEFSMJLZEOE-UHFFFAOYSA-N
Smiles	O=C(O)c1ccccc1O
InChI	InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C7H6O3
Molecular Weight	138.12
AlogP	1.09
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	57.53
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	10.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	6-92.9
Enzyme Oxidoreductase	-	-	-	-	0-97
Enzyme Protease Metallo protease Metallo protease MAE clan Metallo protease M34 family	-	-	-	-	6
Enzyme Protease Metallo protease Metallo protease MAM clan Metallo protease M10A subfamily	-	-	-	-	-2-14
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	-	-	-	-	84.99-86.64
Enzyme	-	-	-	-	0-97

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Agaricus bisporus	-	-	-	-	23-97
Bacillus anthracis	-	-	-	-	6
Bos taurus	-	-	-	-	6
Diplodia seriata	-	-	-	-	58
Glycine max	-	-	-	-	48.4
Homo sapiens	-	-	-	-	-2-92.9
Lasiodiplodia theobromae	-	-	-	-	57-58
Mus musculus	-	200	-	-	13-18.5
Neofusicoccum ribis	-	-	-	-	50
Oryctolagus cuniculus	-	-	-	-	0-0
Pseudomonas aeruginosa	-	-	-	-	35-60
Rattus norvegicus	-	-	-	-	36.8
Staphylococcus aureus	-	-	-	-	26.3

Environmental Exposure

Environmental Exposure Map

Countries
Croatia
Hungary
Romania
Slovakia
Sweden

Cross References

Resources	Reference
ChEBI	16914
ChEMBL	CHEMBL424
DrugBank	DB00936
DrugCentral	2416
FDA SRS	O414PZ4LPZ
Human Metabolome Database	HMDB0001895
Guide to Pharmacology	4306
KEGG	C00805
PDB	SAL
PharmGKB	PA451299
PubChem	338
SureChEMBL	SCHEMBL16880297
ZINC	ZINC000000001554

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A. Ross Brown, Charles R. Tyler, and Henri Xhaard. EcoDrugPLUS: An advanced database for drug target conservation analysis and environmental risk assessment. Nucleic Acids Research. In press.

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025