VOSAROXIN

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Search structure


Synonyms	AG-7352 SNS-595 SPC-595 Voreloxin Vosaroxin
Status
Molecule Category	Free-form
ATC	L01XX53
UNII	K6A90IIZ19

Structure


InChI Key	XZAFZXJXZHRNAQ-STQMWFEESA-N
Smiles	CN[C@H]1CN(c2ccc3c(=O)c(C(=O)O)cn(-c4nccs4)c3n2)C[C@@H]1OC
InChI	InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H19N5O4S
Molecular Weight	401.45
AlogP	0.96
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	109.58
Molecular species	ZWITTERION
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
DNA inhibitor	INHIBITOR	PubMed

Target Conservation


Protein: DNA topoisomerase II Description: DNA topoisomerase 2-alpha Organism : Homo sapiens P11388 ENSG00000131747












Protein: DNA topoisomerase II Description: DNA topoisomerase 2-beta Organism : Homo sapiens Q02880 ENSG00000077097

Cross References

Resources	Reference
ChEMBL	CHEMBL68117
DrugBank	DB11999
FDA SRS	K6A90IIZ19
PubChem	9952884
SureChEMBL	SCHEMBL674441
ZINC	ZINC000026186622

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025