VARESPLADIB

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Search structure


Synonyms	LY-315920 LY315920 Varepladib Varespladib Varespladib sodium
Status
Molecule Category	Free-form
UNII	2Q3P98DATH
EPA CompTox	DTXSID50169378

Structure


InChI Key	BHLXTPHDSZUFHR-UHFFFAOYSA-N
Smiles	CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1
InChI	InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H20N2O5
Molecular Weight	380.4
AlogP	2.38
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	8.0
Polar Surface Area	111.62
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Phospholipase A2 group IIA inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	7-750	-	-	-
Enzyme	-	7-750	-	-	-
Unclassified protein	-	114-131	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	7-750	-	-	-
Mus musculus	-	70-750	-	-	-
Sus scrofa	-	48	-	-	-

Target Conservation


Protein: Phospholipase A2 group IIA Description: Phospholipase A2, membrane associated Organism : Homo sapiens P14555 ENSG00000188257

Cross References

Resources	Reference
ChEMBL	CHEMBL148674
DrugBank	DB11909
FDA SRS	2Q3P98DATH
Guide to Pharmacology	9657
PDB	VRD
PubChem	155815
SureChEMBL	SCHEMBL26726
ZINC	ZINC000001543773

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025