TUCATINIB

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Search structure


Synonyms	ARRY-380 Irbinitinib ONT-380 Ont-380 Tucatinib Tukysa
Status
Molecule Category	Free-form
ATC	L01EH03
UNII	234248D0HH

Structure


InChI Key	SDEAXTCZPQIFQM-UHFFFAOYSA-N
Smiles	Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1
InChI	InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C26H24N8O2
Molecular Weight	480.53
AlogP	5.09
Hydrogen Bond Acceptor	10.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	110.85
Molecular species	NEUTRAL
Aromatic Rings	5.0
Heavy Atoms	36.0

Pharmacology

Mechanism of Action	Action	Reference
Receptor protein-tyrosine kinase erbB-2 inhibitor	INHIBITOR	Other Other

Target Conservation


Protein: Receptor protein-tyrosine kinase erbB-2 Description: Receptor tyrosine-protein kinase erbB-2 Organism : Homo sapiens P04626 ENSG00000141736

Cross References

Resources	Reference
ChEMBL	CHEMBL3989868
DrugBank	DB11652
DrugCentral	5389
FDA SRS	234248D0HH
Guide to Pharmacology	9922
PubChem	51039094
SureChEMBL	SCHEMBL1193050
ZINC	ZINC000068250462

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025