PAZUFLOXACIN

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Search structure


Synonyms	Pazufloxacin T-3761
Status
Molecule Category	Free-form
ATC	J01MA18
UNII	4CZ1R38NDI
EPA CompTox	DTXSID5046697

Structure


InChI Key	XAGMUUZPGZWTRP-ZETCQYMHSA-N
Smiles	C[C@H]1COc2c(C3(N)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
InChI	InChI=1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H15FN2O4
Molecular Weight	318.3
AlogP	1.74
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	94.55
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Bacterial DNA gyrase inhibitor	INHIBITOR	Other

Target Conservation


Protein: DNA topoisomerase II Description: DNA topoisomerase 2-alpha Organism : Homo sapiens P11388 ENSG00000131747












Protein: DNA topoisomerase II Description: DNA topoisomerase 2-beta Organism : Homo sapiens Q02880 ENSG00000077097

Cross References

Resources	Reference
ChEBI	94700
ChEMBL	CHEMBL240163
DrugBank	DB11774
DrugCentral	2070
FDA SRS	4CZ1R38NDI
PubChem	65957
SureChEMBL	SCHEMBL34460
ZINC	ZINC000003779726

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025