PALOVAROTENE

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Search structure


Synonyms	CLM-001 IPN-60120 IPN60120 Palovarotene R-667 RG-667 RO-3300074 RO3300074 Sohonos
Status
Molecule Category	Free-form
ATC	M09AX11
UNII	28K6I5M16G

Structure


InChI Key	YTFHCXIPDIHOIA-DHZHZOJOSA-N
Smiles	CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21
InChI	InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C27H30N2O2
Molecular Weight	414.55
AlogP	6.15
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	55.12
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	31.0

Pharmacology

Mechanism of Action	Action	Reference
Retinoic acid receptor gamma agonist	AGONIST	PubMed PubMed PubMed Other

Target Conservation


Protein: Retinoic acid receptor gamma Description: Retinoic acid receptor gamma Organism : Homo sapiens P13631 ENSG00000172819

Cross References

Resources	Reference
ChEMBL	CHEMBL2105648
DrugBank	DB12320
FDA SRS	28K6I5M16G
Guide to Pharmacology	8276
PubChem	10295295
SureChEMBL	SCHEMBL4658931
ZINC	ZINC000038467831

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025