EcoDrugPlus


Synonyms	Acuatim Jinofloxacin NSC-759622 Nadifloxacin OPC 7251 OPC-7251
Status
Molecule Category	Free-form
ATC	D10AF05
UNII	6CL9Y5YZEQ
EPA CompTox	DTXSID5046483


InChI Key	JYJTVFIEFKZWCJ-UHFFFAOYSA-N
Smiles	CC1CCc2c(N3CCC(O)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
InChI	InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)

Property Name	Value
Molecular Formula	C19H21FN2O4
Molecular Weight	360.38
AlogP	2.31
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	82.77
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
Bacterial DNA gyrase inhibitor	INHIBITOR	Other PubMed PubMed

Resources	Reference
ChEBI	31889
ChEMBL	CHEMBL363449
DrugBank	DB12447
DrugCentral	1864
FDA SRS	6CL9Y5YZEQ
PubChem	4410
SureChEMBL	SCHEMBL36593

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

NADIFLOXACIN

Structure

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Pharmacology

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