FLECAINIDE

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Search structure


Synonyms	Flecainide NSC-719273 THN-102 COMPONENT FLECAINIDE
Status
Molecule Category	Free-form
ATC	C01BC04
UNII	K94FTS1806
EPA CompTox	DTXSID8023054

Structure


InChI Key	DJBNUMBKLMJRSA-UHFFFAOYSA-N
Smiles	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F
InChI	InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H20F6N2O3
Molecular Weight	414.35
AlogP	3.44
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	59.59
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	28.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	74

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	15
Rattus norvegicus	-	-	-	-	74

Environmental Exposure

Environmental Exposure Map

Countries
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia

Cross References

Resources	Reference
ChEBI	75984
ChEMBL	CHEMBL652
DrugBank	DB01195
DrugCentral	1176
FDA SRS	K94FTS1806
Human Metabolome Database	HMDB0015326
Guide to Pharmacology	2560
KEGG	C07001
PharmGKB	PA449646
PubChem	3356
SureChEMBL	SCHEMBL14970

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025