ENOXIMONE


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	ZJKNESGOIKRXQY-UHFFFAOYSA-N
Smiles	CSc1ccc(C(=O)c2[nH]c(=O)[nH]c2C)cc1
InChI	InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)

Mechanism of Action	Action	Reference
Phosphodiesterase 3 inhibitor	INHIBITOR	BNF


Protein: Phosphodiesterase 3 Description: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Organism : Homo sapiens Q13370 ENSG00000152270











Protein: Phosphodiesterase 3 Description: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Organism : Homo sapiens Q14432 ENSG00000172572

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A	-	3800-14000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B	-	3800-14000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4A	-	2900-5000	-	-	34
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B	-	2900-5000	-	-	34
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4C	-	2900-5000	-	-	34
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D	-	2900-5000	-	-	34

Assay Description	Organism	Bioactivity
Inhibition of canine kidney Phosphodiesterase 4 at 0.5 uM	Canis lupus familiaris	34.0 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	6.41 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	49.7 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.11 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.11 %

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