DEXRAZOXANE

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC V03AF02
UNII 048L81261F
EPA CompTox DTXSID3040647

Structure

InChI Key BMKDZUISNHGIBY-ZETCQYMHSA-N
Smiles C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
InChI
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H16N4O4
Molecular Weight 268.27
AlogP -2.71
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 98.82
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 19.0

Pharmacology

Mechanism of Action Action Reference
DNA topoisomerase II inhibitor INHIBITOR EMA

Target Conservation

Protein: DNA topoisomerase II
Description: DNA topoisomerase 2-alpha
Organism : Homo sapiens
P11388 ENSG00000131747
Protein: DNA topoisomerase II
Description: DNA topoisomerase 2-beta
Organism : Homo sapiens
Q02880 ENSG00000077097

Related Entries

Cross References

Resources Reference
ChEBI 50223
ChEMBL CHEMBL1738
DrugBank DB00380
DrugCentral 839
FDA SRS 048L81261F
Human Metabolome Database HMDB0014524
Guide to Pharmacology 7330
PharmGKB PA449259
PubChem 71384
SureChEMBL SCHEMBL18400
ZINC ZINC000087515509
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