DEXRAZOXANE


Synonyms	ADR-529 Cardioxane Dexrazoxane ICRF-187 NSC-169780 Razoxane, (s)- Razoxane, d- Zinecard
Status
Molecule Category	Free-form
ATC	V03AF02
UNII	048L81261F
EPA CompTox	DTXSID3040647


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	BMKDZUISNHGIBY-ZETCQYMHSA-N
Smiles	C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
InChI	InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

Mechanism of Action	Action	Reference
DNA topoisomerase II inhibitor	INHIBITOR	EMA


Protein: DNA topoisomerase II Description: DNA topoisomerase 2-alpha Organism : Homo sapiens P11388 ENSG00000131747











Protein: DNA topoisomerase II Description: DNA topoisomerase 2-beta Organism : Homo sapiens Q02880 ENSG00000077097

Assay Description	Organism	Bioactivity	Reference
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	30.8 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.12 %		Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.12 %

CONTENTS