EcoDrugPlus


Synonyms	(r)-pramipexole Dexpramipexole
Status
Molecule Category	Free-form
UNII	WI638GUS96
EPA CompTox	DTXSID50146624


InChI Key	FASDKYOPVNHBLU-SSDOTTSWSA-N
Smiles	CCCN[C@@H]1CCc2nc(N)sc2C1
InChI	InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1

Property Name	Value
Molecular Formula	C10H17N3S
Molecular Weight	211.33
AlogP	1.58
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	50.94
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	14.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	-	-	0.6607	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	0.6607	-

Resources	Reference
ChEMBL	CHEMBL249420
DrugBank	DB15130
FDA SRS	WI638GUS96
PharmGKB	PA164742949
PubChem	59868
SureChEMBL	SCHEMBL74780
ZINC	ZINC000003831352

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

DEXPRAMIPEXOLE

Structure

Physicochemical Descriptors

Pharmacology

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