DEXKETOPROFEN


Synonyms	(s)-ketoprofen Arveles Dexketoprofen Keral Ketoprofen, (s)-
Status
Molecule Category	Free-form
ATC	M01AE17 M02AA27
UNII	6KD9E78X68


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	DKYWVDODHFEZIM-NSHDSACASA-N
Smiles	C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1
InChI	InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303











Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	2	-	-	-
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor	-	50	-	-	52

Assay Description	Organism	Bioactivity
Concentration required for 50% inhibition against Prostaglandin G/H synthase 2 from human	None	27.0 nM
Concentration required for 50% inhibition against Prostaglandin G/H synthase 1 from human	None	1.9 nM
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells	Homo sapiens	50.0 nM
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M	Mus musculus	99.0 %
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M	Homo sapiens	52.0 %
DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	Homo sapiens	4.483 nM
DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	None	230.0 nM
Anti-inflammatory activity in Rattus norvegicus Fischer-344 (rat) assessed as inhibition of carrageenan-induced paw oedema at 0.30 mmol/kg, ip administered 5 min before FCA challenge measured after 3 hr relative to control	Rattus norvegicus	42.0 %

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