EcoDrugPlus


Synonyms	Daprodustat GSK-1278863 GSK1278863
Status
Molecule Category	Free-form
UNII	JVR38ZM64B

Synonyms

Daprodustat

GSK-1278863

GSK1278863

Status

Molecule Category

Free-form

UNII

JVR38ZM64B


InChI Key	RUEYEZADQJCKGV-UHFFFAOYSA-N
Smiles	O=C(O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O
InChI	InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)

InChI Key

RUEYEZADQJCKGV-UHFFFAOYSA-N

Smiles

O=C(O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O

InChI

InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)

Property Name	Value
Molecular Formula	C19H27N3O6
Molecular Weight	393.44
AlogP	1.26
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	124.09
Molecular species	ACID
Aromatic Rings	0.0
Heavy Atoms	28.0

Property Name

Value

Molecular Formula

C19H27N3O6

Molecular Weight

393.44

AlogP

1.26

Hydrogen Bond Acceptor

5.0

Hydrogen Bond Donor

2.0

Number of Rotational Bond

5.0

Polar Surface Area

124.09

Molecular species

ACID

Aromatic Rings

0.0

Heavy Atoms

28.0

Mechanism of Action	Action	Reference
Hypoxia-inducible factor prolyl hydroxylase inhibitor	INHIBITOR	PubMed

Mechanism of Action

Action

Reference

Hypoxia-inducible factor prolyl hydroxylase inhibitor

INHIBITOR

PubMed

Resources	Reference
ChEMBL	CHEMBL3544988
DrugBank	DB11682
FDA SRS	JVR38ZM64B
Guide to Pharmacology	8455
PubChem	91617630
ZINC	ZINC000231226004

Resources

Reference

ChEMBL

CHEMBL3544988

DrugBank

DB11682

FDA SRS

JVR38ZM64B

Guide to Pharmacology

8455

PubChem

91617630

ZINC

ZINC000231226004

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

DAPRODUSTAT

Structure

Physicochemical Descriptors

Pharmacology

Cross References