DAPOXETINE

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Search structure


Synonyms	Dapoxetine Kutub LY-210448
Status
Molecule Category	Free-form
ATC	G04BX14
UNII	GB2433A4M3
EPA CompTox	DTXSID0057627

Structure


InChI Key	USRHYDPUVLEVMC-FQEVSTJZSA-N
Smiles	CN(C)[C@@H](CCOc1cccc2ccccc12)c1ccccc1
InChI	InChI=1S/C21H23NO/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21/h3-14,20H,15-16H2,1-2H3/t20-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H23NO
Molecular Weight	305.42
AlogP	4.91
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	12.47
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Serotonin transporter inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed PubMed PMC

Target Conservation


Protein: Serotonin transporter Description: Sodium-dependent serotonin transporter Organism : Homo sapiens P31645 ENSG00000108576

Cross References

Resources	Reference
ChEBI	135962
ChEMBL	CHEMBL2110900
DrugBank	DB04884
DrugCentral	4381
FDA SRS	GB2433A4M3
Guide to Pharmacology	7901
PharmGKB	PA166151992
PubChem	71353
SureChEMBL	SCHEMBL34479
ZINC	ZINC000001482019

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025