UREA

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Search structure


Trade Names	STERILE UREA UREAPHIL
Synonyms	Aquadrate Azodicarboxylic acid-diamide Balneum plus Calmurid Carbamide E-927A E927b Eucerin Flexifoot Flexitol Hydromol intensive INS NO.927A INS-927A NSC-34375 Nutraplus
Status
Molecule Category	Free-form
UNII	8W8T17847W
EPA CompTox	DTXSID4021426

Structure


InChI Key	XSQUKJJJFZCRTK-UHFFFAOYSA-N
Smiles	NC(N)=O
InChI	InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	CH4N2O
Molecular Weight	60.06
AlogP	-0.98
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	2.0
Polar Surface Area	69.11
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	4.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	87.46-105.91

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	87.46-105.91

Cross References

Resources	Reference
ChEBI	16199
ChEMBL	CHEMBL985
DrugBank	DB03904
DrugCentral	4264
FDA SRS	8W8T17847W
Human Metabolome Database	HMDB0000294
Guide to Pharmacology	4539
KEGG	C00086
PDB	URE
PharmGKB	PA451831
PubChem	1176
SureChEMBL	SCHEMBL4441
ZINC	ZINC000008214514

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025