TRIPELENNAMINE HYDROCHLORIDE

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Search structure


Trade Names	PBZ PBZ-SR TRIPELENNAMINE HYDROCHLORIDE
Synonyms	Azaron Dehistin NSC-409943 Pbz-sr Pyribenzamine Tripelennamine chloride Tripelennamine hcl Tripelennamine hydrochloride Vetibenzamina
Status
Molecule Category	Salt-form
UNII	FWV8GJ56ZN
EPA CompTox	DTXSID6026248

Structure


InChI Key	FSSICIQKZGUEAE-UHFFFAOYSA-N
Smiles	CN(C)CCN(Cc1ccccc1)c1ccccn1.Cl
InChI	InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H22ClN3
Molecular Weight	291.83
AlogP	2.65
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	19.37
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	19.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	PubMed

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEMBL	CHEMBL1200446
FDA SRS	FWV8GJ56ZN
Guide to Pharmacology	7318
KEGG	C07180
PubChem	9066
SureChEMBL	SCHEMBL98916
ZINC	ZINC00057524

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025