TRIAMTERENE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC C03DB02
UNII WS821Z52LQ
EPA CompTox DTXSID6021373

Structure

InChI Key FNYLWPVRPXGIIP-UHFFFAOYSA-N
Smiles Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
InChI
InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H11N7
Molecular Weight 253.27
AlogP 0.83
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 1.0
Polar Surface Area 129.62
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 19.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action Action Reference
Amiloride-sensitive sodium channel, ENaC blocker BLOCKER PubMed DailyMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase RSK family AGC protein kinase p70 subfamily
- - - - 95
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase SGK family
- - - - 94
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase PAKA subfamily
- - - - 100
Enzyme Oxidoreductase
- - - - 21
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 69.61-78.63
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 69.61-78.63

Target Conservation

Protein: Amiloride-sensitive sodium channel, ENaC
Description: Amiloride-sensitive sodium channel subunit alpha
Organism : Homo sapiens
P37088 ENSG00000111319
Protein: Amiloride-sensitive sodium channel, ENaC
Description: Amiloride-sensitive sodium channel subunit beta
Organism : Homo sapiens
P51168 ENSG00000168447
Protein: Amiloride-sensitive sodium channel, ENaC
Description: Amiloride-sensitive sodium channel subunit gamma
Organism : Homo sapiens
P51170 ENSG00000166828

Related Entries

Environmental Exposure

Environmental Exposure Map
Countries
Croatia
Germany
Hungary
USA

Cross References

Resources Reference
ChEBI 9671
ChEMBL CHEMBL585
DrugBank DB00384
DrugCentral 2728
FDA SRS WS821Z52LQ
Human Metabolome Database HMDB0001940
Guide to Pharmacology 4329
PDB DX2
PharmGKB PA451752
PubChem 5546
SureChEMBL SCHEMBL40707
ZINC ZINC000000120286
CONTENTS