PRASTERONE


Trade Names	INTRAROSA
Synonyms	Biolaif Dehydroandrosterone Dehydroepiandrosterone Dehydroisoandrosterone Dhea EM-760 Enzymatic therapy Intrarosa NSC-9896 Natrol dhea Prasterone Vaginorm
Status
Molecule Category	Free-form
ATC	A14AA07 G03XX01
UNII	459AG36T1B
EPA CompTox	DTXSID4020379


InChI Key	FMGSKLZLMKYGDP-USOAJAOKSA-N
Smiles	C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
InChI	InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

Property Name	Value
Molecular Formula	C19H28O2
Molecular Weight	288.43
AlogP	3.88
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Polar Surface Area	37.3
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	21.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	-	-	-	5.7-12.1
Secreted protein	-	-	14.45	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	14.45	-	5.7-12.1
Mus musculus	-	141	-	-	40-55.3
Rattus norvegicus	-	0.29-1.65	-	-	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	28689
ChEMBL	CHEMBL90593
DrugBank	DB01708
DrugCentral	795
FDA SRS	459AG36T1B
Human Metabolome Database	HMDB0000077
Guide to Pharmacology	2370
KEGG	C01227
PDB	AND
PharmGKB	PA451993
PubChem	5881
SureChEMBL	SCHEMBL24156
ZINC	ZINC000003807917

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PRASTERONE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References