In vitro antiamnesic activity was evaluated against HK-9 strain of Entamoeba histolytica
|
Entamoeba histolytica
|
0.22
ug.mL-1
|
|
In vitro antiprotozoal activity against Entamoeba histolytica
|
Entamoeba histolytica
|
350.0
nM
|
|
Tested for antiamnesic activity against HK-9 strain of Entamoeba histolytica
|
Entamoeba histolytica
|
0.33
ug.mL-1
|
|
The compound was tested in vitro against the protozoa Entamoeba histolytica, for the inhibition of tubulin polymerization in rat brain
|
Entamoeba histolytica
|
350.0
nM
|
|
Antiprotozoal activity against Trichomonas vaginalis
|
Trichomonas vaginalis
|
286.0
nM
|
|
Antiprotozoal activity against Entamoeba histolytica
|
Entamoeba histolytica
|
771.0
nM
|
|
Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS trophozoites after 48 hrs by MTT/PMS assay
|
Entamoeba histolytica HM-1:IMSS
|
0.04
ug.mL-1
|
|
Antiprotozoal activity against Giardia lamblia IMSS:0989:1 after 48 hrs by MTT/PMS assay
|
Giardia intestinalis
|
0.21
ug.mL-1
|
|
Antifungal activity against Giardia intestinalis ATCC 30888 after 48 hrs by XTT assay
|
Giardia intestinalis
|
0.1
ug.mL-1
|
|
Antiprotozoal activity against axenically grown trophozoites of Giardia lamblia IMSS:0989:1 after 48 hrs by MTT method
|
Giardia intestinalis
|
0.21
ug.mL-1
|
|
Antiprotozoal activity against axenically grown trophozoites of Entamoeba histolytica HM1-IMSS after 48 hrs by MTT method
|
Entamoeba histolytica
|
0.04
ug.mL-1
|
|
Antiprotozoal activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs
|
Trichomonas vaginalis
|
236.0
nM
|
|
Antiparasitic activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs by Hill culture method
|
Trichomonas vaginalis
|
290.0
nM
|
|
Antiamnesic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 48 hrs by Hill culture method
|
Entamoeba histolytica HM-1:IMSS
|
770.0
nM
|
|
Antigiardial activity against Giardia lamblia WB (ATCC 30957) trophozoites after 24 hrs by trypan blue assay
|
Giardia intestinalis
|
2.88
ug.mL-1
|
|
Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS after 48 hrs
|
Entamoeba histolytica HM-1:IMSS
|
350.0
nM
|
|
Antiprotozoal activity against Trichomonas vaginalis G3 after 48 hrs
|
Trichomonas vaginalis G3
|
216.0
nM
|
|
Antiparasitic activity against Trichomonas vaginalis T1 after 24 hrs by hemocytometric analysis
|
Trichomonas vaginalis
|
720.0
nM
|
|
Antiparasitic activity against Trichomonas vaginalis G3 after 24 hrs by hemocytometric analysis
|
Trichomonas vaginalis G3
|
770.0
nM
|
|
Antimicrobial activity against Trichomonas vaginalis GT3 after 48 hrs
|
Trichomonas vaginalis
|
290.0
nM
|
|
Antimicrobial activity against Entamoeba histolytica HM-1:IMSS after 48 hrs
|
Entamoeba histolytica HM-1:IMSS
|
770.0
nM
|
|
Inhibition of Helicobacter pylori invasion into human AGS cells at 2.5 uM after 6 hrs
|
Helicobacter pylori
|
20.0
%
|
|
Inhibition of Helicobacter pylori-induced inflammation in human AGS cells assessed as reduction of IL-8 production at 10 uM by ELISA
|
Helicobacter pylori
|
81.9
%
|
|
Antitrypanosomal activity against Trichomonas vaginalis T1
|
Trichomonas vaginalis
|
720.0
nM
|
|
Antitrypanosomal activity against Trichomonas vaginalis T1
|
Trichomonas vaginalis
|
0.12
ug.mL-1
|
|
Antimicrobial activity against Escherichia coli JM109 transformed with empty vector PQE30 after 16 hrs
|
Escherichia coli
|
25.0
ug.mL-1
|
|
Antimicrobial activity against Escherichia coli JM109 transformed with Entamoeba histolytica NTR1 after 16 hrs
|
Escherichia coli
|
7.0
ug.mL-1
|
|
Antimicrobial activity against Escherichia coli JM109 transformed with Entamoeba histolytica NTR2 after 16 hrs
|
Escherichia coli
|
8.0
ug.mL-1
|
|
Antimicrobial activity against Escherichia coli JM109 transformed with Entamoeba histolytica nim1 after 16 hrs
|
Escherichia coli
|
750.0
ug.mL-1
|
|
Antimicrobial activity against Escherichia coli JM109 transformed with Trichomonas vaginalis nim1 after 16 hrs
|
Escherichia coli
|
500.0
ug.mL-1
|
|
Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites after 48 hrs
|
Trichomonas vaginalis
|
290.0
nM
|
|
Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites after 48 hrs
|
Entamoeba histolytica
|
770.0
nM
|
|
Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites compound treated for 48 hrs measured after 48 hrs washout period
|
Trichomonas vaginalis
|
236.0
nM
|
|
Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites compound treated for 48 hrs measured after 48 hrs washout period
|
Entamoeba histolytica
|
350.0
nM
|
|
Growth inhibition of Trichomonas vaginalis T1 after 24 hrs by hemocytometry
|
Trichomonas vaginalis
|
720.0
nM
|
|
Growth inhibition of mtronidazole-resistant Trichomonas vaginalis after 24 hrs by hemocytometry
|
Trichomonas vaginalis
|
210.0
nM
|
|
Inhibition of Helicobacter pylori invasion to human AGS cells at 20 ug/ml after 6 hrs by gentamicin assay relative to control
|
Helicobacter pylori
|
20.0
%
|
|
Inhibition of Helicobacter pylori adhesion to human AGS cells at 20 ug/ml after 6 hrs by gentamicin assay relative to control
|
Helicobacter pylori
|
20.0
%
|
|
Antibacterial activity against Trichomonas vaginalis G3 after 24 hrs by hemocytometry
|
Trichomonas vaginalis G3
|
720.0
nM
|
|
Antiprotozoal activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs by haemocytometric analysis
|
Entamoeba histolytica HM-1:IMSS
|
379.8
nM
|
|
Antiprotozoal activity against trophozoite stage of Trichomonas vaginalis GT3 assessed as growth inhibition after 48 hrs by haemocytometric analysis
|
Trichomonas vaginalis
|
236.0
nM
|
|
Antiprotozoal activity against clinical isolates of Giardia lamblia IMSS:8901:1
|
Giardia intestinalis
|
0.21
ug.mL-1
|
|
Antiprotozoal activity against clinical isolates of Entamoeba histolytica HM-1:IMSS
|
Entamoeba histolytica HM-1:IMSS
|
0.04
ug.mL-1
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
102.59
%
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
98.27
%
|
|
Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products at 500 uM preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method relative to control
|
Homo sapiens
|
17.0
%
|
|
Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS
|
Entamoeba histolytica HM-1:IMSS
|
230.0
nM
|
|
Antimicrobial activity against Trichomonas vaginalis GT3 incubated for 48 hrs followed by compound washout measured after 48 hrs
|
Trichomonas vaginalis
|
316.23
nM
|
|
Antimicrobial activity against Trichomonas vaginalis GT3 incubated for 48 hrs followed by compound washout measured after 48 hrs
|
Trichomonas vaginalis
|
290.0
nM
|
|
Antiprotozoal activity against trophozoite stage of Trichomonas vaginalis GT3 assessed as growth inhibition
|
Trichomonas vaginalis
|
0.037
ug.mL-1
|
|
Antiprotozoal activity against trophozoite stage of Giardia lamblia IMSS:8909:1 assessed as growth inhibition after 48 hrs
|
Giardia intestinalis
|
1.22
ug.mL-1
|
|
Antiprotozoal activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs
|
Entamoeba histolytica HM-1:IMSS
|
0.23
ug.mL-1
|
|
Antimicrobial activity against Trichomonas vaginalis G3 assessed as growth inhibition after 24 hrs by hemocytometry
|
Trichomonas vaginalis G3
|
720.0
nM
|
|
Antiprotozoal activity against Giardia lamblia assessed as growth inhibition
|
Giardia intestinalis
|
580.0
nM
|
|
Antiprotozoan activity against Giardia lamblia G1
|
Giardia intestinalis
|
580.0
nM
|
|
Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS trophozoites assessed as growth inhibition compound treated for 48 hrs measured 48 hrs post wash-out by MTT assay
|
Entamoeba histolytica HM-1:IMSS
|
0.04
ug.mL-1
|
|
Antiprotozoal activity against Giardia lamblia IMSS: 8909:1 trophozoites assessed as growth inhibition compound treated for 48 hrs measured 48 hrs post wash-out by MTT assay
|
Giardia intestinalis
|
0.21
ug.mL-1
|
|
Trichomonicidal activity against Trichomonas vaginalis GT3 compound treated for 48 hrs followed by incubation for 48 hrs in compound-free medium by cell counting
|
Trichomonas vaginalis
|
290.0
nM
|
|
Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 1 hr relative to control
|
Rattus norvegicus
|
66.3
%
|
|
Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 2 hrs relative to control
|
Rattus norvegicus
|
66.3
%
|
|
Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 3 hrs relative to control
|
Rattus norvegicus
|
60.8
%
|
|
Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 4 hrs relative to control
|
Rattus norvegicus
|
58.9
%
|
|
Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg indomethacin mol equivalent, ip administered 1 hr prior to carrageenan challenge measured at 24 hrs relative to control
|
Rattus norvegicus
|
0.0
%
|
|
Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 300 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method
|
Trichomonas vaginalis
|
100.0
%
|
|
Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 150 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method
|
Trichomonas vaginalis
|
100.0
%
|
|
Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 75 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method
|
Trichomonas vaginalis
|
100.0
%
|
|
Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 37.5 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method
|
Trichomonas vaginalis
|
99.37
%
|
|
Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 18.75 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method
|
Trichomonas vaginalis
|
95.98
%
|
|
Trichomonicidal activity against Trichomonas vaginalis JH31A#4 trophozite assessed as inhibition of parasite growth at 9.37 uM after 24 hrs by resazurin redox dye based fluorimetric microtiter method
|
Trichomonas vaginalis
|
82.69
%
|
|
Trichomonicidal activity against Trichomonas vaginalis C-1:NIH trophozoites infected in NMRI mouse assessed as reduction of pathogenicity at 25 mg/kg/day, po administered for 7 days from day 3 to day 10 post-infection measured at day 15 post-infection
|
Trichomonas vaginalis
|
93.96
%
|
|
Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS
|
Entamoeba histolytica HM-1:IMSS
|
230.0
nM
|
|
Antiparasitic activity against metronidazole sensitive Trichomonas vaginalis F1623 trophozoites after 24 to 48 hrs under anaerobic conditions by Celltiter-Glo assay
|
Trichomonas vaginalis
|
800.0
nM
|
|
Antiparasitic activity against metronidazole sensitive Trichomonas vaginalis F1623 trophozoites after 24 to 48 hrs under anaerobic conditions by Celltiter-Glo assay
|
Trichomonas vaginalis
|
794.33
nM
|
|
Antiprotozoal activity against Trichomonas vaginalis GT3 trophozoites incubated for 48 hrs
|
Trichomonas vaginalis
|
290.0
nM
|
|
Antiparasitic activity against trophozoite stage of Trichomonas vaginalis CNCD 147 after 48 hrs
|
Trichomonas vaginalis
|
236.0
nM
|
|
Antiparasitic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS after 48 hrs
|
Entamoeba histolytica HM-1:IMSS
|
379.8
nM
|
|
Inhibition of Bacillus pasteurii urease using urea as substrate measured after 20 mins by phenol reagent based assay relative to control
|
Sporosarcina pasteurii
|
13.0
%
|
|
Antiparasitic activity against Trichomonas vaginalis assessed as parasite growth inhibition after 24 hrs by hemacytometer
|
Trichomonas vaginalis
|
720.0
nM
|
|
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600)
|
Staphylococcus aureus subsp. aureus
|
17.23
%
|
|
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600)
|
Escherichia coli
|
2.82
%
|
|
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600)
|
Klebsiella pneumoniae
|
13.91
%
|
|
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600)
|
Pseudomonas aeruginosa
|
12.01
%
|
|
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600
|
Acinetobacter baumannii
|
26.53
%
|
|
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630
|
Candida albicans
|
1.89
%
|
|
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570)
|
Cryptococcus neoformans
|
-8.47
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
3.8
%
|
|
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
|
Homo sapiens
|
278.08
ug.mL-1
|
|
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
|
Homo sapiens
|
223.78
ug.mL-1
|
|
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
|
Homo sapiens
|
347.96
ug.mL-1
|
|
Antiparasitic activity against Entamoeba histolytica HM1-IMSS trophozoites assessed as inhibition of parasitic growth treated for 48 hrs followed by compound washout and measured after 48 hrs by MTT/PMS dye based colorimetric method
|
Entamoeba histolytica
|
200.0
nM
|
|
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes harboring luciferase reporter gene at 50 uM after 48 hrs by Steady-Glo luminescence assay relative to control
|
Leishmania donovani
|
62.2
%
|
|
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes harboring luciferase reporter gene at 25 uM after 48 hrs by Steady-Glo luminescence assay relative to control
|
Leishmania donovani
|
41.3
%
|
|
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 amastigotes harboring luciferase reporter gene infected in mouse J774 cells at 50 uM after 48 hrs by Steady-Glo luminescence assay relative to control
|
Leishmania donovani
|
68.1
%
|
|
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 amastigotes harboring luciferase reporter gene infected in mouse J774 cells at 25 uM after 48 hrs by Steady-Glo luminescence assay relative to control
|
Leishmania donovani
|
31.2
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
18.14
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.2
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.2
%
|
|
Antigiardial activity against Giardia duodenalis GS/M-83-H7 (ATCC 50581) incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis WB (ATCC 30957) incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis G1 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis Ah1 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis Ah2 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis Ac1 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis Ac2 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis Ec1 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia duodenalis Ec2 incubated for 3 days by fluorescence method
|
Giardia intestinalis
|
500.0
nM
|
|
Antigiardial activity against Giardia lamblia WB (ATCC 30957) incubated for 3 days by [3H]thymidine incorporation based assay
|
Giardia intestinalis
|
500.0
nM
|
|
Anti-trichomonas activity against Trichomonas vaginalis JT incubated for 48 hrs by hemocytometer based eosin exclusion assay
|
Trichomonas vaginalis
|
68.0
nM
|
|
Anti-trichomonas activity against Trichomonas vaginalis CDC 085 incubated for 48 hrs by hemocytometer based eosin exclusion assay
|
Trichomonas vaginalis
|
490.0
nM
|
|
Anti-trichomonas activity against Trichomonas vaginalis GT3 incubated for 48 hrs
|
Trichomonas vaginalis
|
930.0
nM
|
|