METHYLPREDNISOLONE SODIUM SUCCINATE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII LEC9GKY20K
EPA CompTox DTXSID2023303
Parent Compound: METHYLPREDNISOLONE

Structure

InChI Key FQISKWAFAHGMGT-SGJOWKDISA-M
Smiles C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)COC(=O)CCC(=O)[O-])[C@@]2(C)C=CC(=O)C=C12.[Na+]
InChI
InChI=1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H33NaO8
Molecular Weight 496.53
AlogP 2.22
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 6.0
Polar Surface Area 138.2
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 34.0

Pharmacology

Mechanism of Action Action Reference
Glucocorticoid receptor agonist AGONIST FDA
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Rattus norvegicus
- 0 - - 0

Target Conservation

Protein: Glucocorticoid receptor
Description: Glucocorticoid receptor
Organism : Homo sapiens
P04150 ENSG00000113580

Cross References

Resources Reference
ChEBI 6890
ChEMBL CHEMBL1201081
FDA SRS LEC9GKY20K
PubChem 23680530
SureChEMBL SCHEMBL40947
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