METHYLDOPATE HYDROCHLORIDE

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Search structure


Trade Names	ALDOMET METHYLDOPATE HCL METHYLDOPATE HYDROCHLORIDE
Synonyms	Aldomet Methyldopa l-form ethyl ester hydrochloride Methyldopate hcl Methyldopate hydrochloride NSC-760088
Status
Molecule Category	Salt-form
UNII	7PX435DN5A
EPA CompTox	DTXSID1045370

Structure


InChI Key	QSRVZCCJDKYRRF-YDALLXLXSA-N
Smiles	CCOC(=O)[C@@](C)(N)Cc1ccc(O)c(O)c1.Cl
InChI	InChI=1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C12H18ClNO4
Molecular Weight	275.73
AlogP	0.92
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	92.78
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-2 agonist	AGONIST	DailyMed Wikipedia

Target Conservation


Protein: Adrenergic receptor alpha-2 Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha-2 Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286











Protein: Adrenergic receptor alpha-2 Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160

Cross References

Resources	Reference
ChEMBL	CHEMBL1200432
FDA SRS	7PX435DN5A
PubChem	17276
SureChEMBL	SCHEMBL41131

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025