METHYLDOPATE HYDROCHLORIDE


Trade Names	ALDOMET METHYLDOPATE HCL METHYLDOPATE HYDROCHLORIDE
Synonyms	Aldomet Methyldopa l-form ethyl ester hydrochloride Methyldopate hcl Methyldopate hydrochloride NSC-760088
Status
Molecule Category	Salt-form
UNII	7PX435DN5A
EPA CompTox	DTXSID1045370


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	QSRVZCCJDKYRRF-YDALLXLXSA-N
Smiles	CCOC(=O)[C@@](C)(N)Cc1ccc(O)c(O)c1.Cl
InChI	InChI=1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-2 agonist	AGONIST	DailyMed Wikipedia


Protein: Adrenergic receptor alpha-2 Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha-2 Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286










Protein: Adrenergic receptor alpha-2 Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160

Assay Description	Organism	Bioactivity
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	7.89 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	2.645 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.04 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.04 %

CONTENTS