MEFLOQUINE HYDROCHLORIDE

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Search structure


Trade Names	LARIAM MEFLOQUINE HYDROCHLORIDE
Synonyms	Fansimef Lariam Loriam Mefloquine hcl Mefloquine hydrochloride Mefloquini hydrochloridum NSC-157387 RO 21-5998/001 RO-21-5998 RO-215998001 WR-142490
Status
Molecule Category	Salt-form
UNII	5Y9L3636O3
Parent Compound:	MEFLOQUINE

Structure


InChI Key	WESWYMRNZNDGBX-UHFFFAOYSA-N
Smiles	Cl.OC(c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)C1CCCCN1
InChI	InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H17ClF6N2O
Molecular Weight	414.78
AlogP	4.45
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	45.15
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	26.0

Pharmacology

Mechanism of Action	Action	Reference
Ferriprotoporphyrin IX inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Phosphatase	-	-	-	-	54
Enzyme	-	-	-	-	54

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	54-54
Plasmodium falciparum	-	1.9-9.4	-	-	-
Plasmodium falciparum D6	-	6	-	-	-
Plasmodium falciparum K1	-	40	-	-	-

Cross References

Resources	Reference
ChEBI	63687
ChEMBL	CHEMBL535650
FDA SRS	5Y9L3636O3
Guide to Pharmacology	4252
KEGG	C07633
SureChEMBL	SCHEMBL41095
ZINC	ZINC00897085

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025