EcoDrugPlus


Trade Names	LEVOPROME
Synonyms	CL 36467 CL 39743 CL-36467 CL-39743 Levomepromazine Levoprome Methotrimeprazine N05AA02 NSC-226516 Neozine Nirvan RP 7044 RP-7044 SK&F 5116 SK&F-5116
Status
Molecule Category	Free-form
ATC	N05AA02
UNII	9G0LAW7ATQ
EPA CompTox	DTXSID1023289


InChI Key	VRQVVMDWGGWHTJ-CQSZACIVSA-N
Smiles	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2
InChI	InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1

Property Name	Value
Molecular Formula	C19H24N2OS
Molecular Weight	328.48
AlogP	4.5
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	5.0
Polar Surface Area	15.71
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	23.0

Mechanism of Action	Action	Reference
D2-like dopamine receptor antagonist	ANTAGONIST	ISBN Wikipedia Wikipedia

Resources	Reference
ChEBI	6838
ChEMBL	CHEMBL1764
DrugBank	DB01403
DrugCentral	1752
FDA SRS	9G0LAW7ATQ
Human Metabolome Database	HMDB0015474
Guide to Pharmacology	7603
KEGG	C07192
PharmGKB	PA164743234
PubChem	72287
SureChEMBL	SCHEMBL25462
ZINC	ZINC000000020246

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

LEVOMEPROMAZINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

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