LESINURAD

/static/temp/default.svg

Search structure


Trade Names	ZURAMPIC
Synonyms	Lesinurad RDEA 594 RDEA-594 RDEA594 Zurampic
Status
Molecule Category	Free-form
ATC	M04AB05
UNII	09ERP08I3W

Structure


InChI Key	FGQFOYHRJSUHMR-UHFFFAOYSA-N
Smiles	O=C(O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12
InChI	InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H14BrN3O2S
Molecular Weight	404.29
AlogP	4.24
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	68.01
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	24.0

Pharmacology

Mechanism of Action	Action	Reference
Solute carrier family 22 member 12 inhibitor	INHIBITOR	FDA

Target Conservation


Protein: Solute carrier family 22 member 12 Description: Solute carrier family 22 member 12 Organism : Homo sapiens Q96S37 ENSG00000197891

Cross References

Resources	Reference
ChEBI	90929
ChEMBL	CHEMBL2105720
DrugBank	DB11560
DrugCentral	5075
FDA SRS	09ERP08I3W
Guide to Pharmacology	7673
PharmGKB	PA166160006
PubChem	53465279
SureChEMBL	SCHEMBL842962
ZINC	ZINC000084757007

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025