LENALIDOMIDE


Trade Names	REVLIMID
Synonyms	CC-5013 CDC-501 Lenalidomide NSC-747972 Revlimid SYP-1512
Status
Molecule Category	Free-form
ATC	L04AX04
UNII	F0P408N6V4
EPA CompTox	DTXSID8046664


InChI Key	GOTYRUGSSMKFNF-UHFFFAOYSA-N
Smiles	Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
InChI	InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

Property Name	Value
Molecular Formula	C13H13N3O3
Molecular Weight	259.26
AlogP	0.03
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	92.5
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	19.0

Mechanism of Action	Action	Reference
CRL4(CRBN) E3 ubiquitin ligase inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Other cytosolic protein	-	-	-	-	4-6
Transcription factor	-	-	-	-	4-6
Unclassified protein	67-87	286	-	-	100

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	53-150	50-480	178	-	4-100
Mus musculus	-	-	-	-	20

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	63791
ChEMBL	CHEMBL848
DrugBank	DB00480
DrugCentral	3317
FDA SRS	F0P408N6V4
Human Metabolome Database	HMDB0014623
Guide to Pharmacology	7331
PharmGKB	PA162363968
PubChem	216326
SureChEMBL	SCHEMBL32978

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

LENALIDOMIDE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References