ISOCARBOXAZID


Trade Names	MARPLAN
Synonyms	Enerzer Isocarboxazid Marplan NSC-169893 RO 5-0831 RO-5-0831
Status
Molecule Category	UNKNOWN
ATC	N06AF01
UNII	34237V843T
EPA CompTox	DTXSID4023171


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	XKFPYPQQHFEXRZ-UHFFFAOYSA-N
Smiles	Cc1cc(C(=O)NNCc2ccccc2)no1
InChI	InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16)

Mechanism of Action	Action	Reference
Monoamine oxidase inhibitor	INHIBITOR	FDA Wikipedia


Protein: Monoamine oxidase Description: Amine oxidase [flavin-containing] A Organism : Homo sapiens P21397 ENSG00000189221











Protein: Monoamine oxidase Description: Amine oxidase [flavin-containing] B Organism : Homo sapiens P27338 ENSG00000069535

Assay Description	Organism	Bioactivity
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	-11.35 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	13.63 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.0 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.0 %

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