HYDROCHLOROTHIAZIDE


Trade Names	ESIDRIX HYDRO-D HYDROCHLOROTHIAZIDE HYDROCHLOROTHIAZIDE INTENSOL HYDRODIURIL MICROZIDE ORETIC ZIDE
Synonyms	Apo-hydro Apresazide Carozide Chlorosulthiadil Copalia-hct Dafiro-hct Dihydrochlorurite Esidrex Esidrix Exforge-hct Hctz Hidrotiazida Hydro-d Hydrochlorothiaizide Hydrochlorothiazide
Status
Molecule Category	Free-form
ATC	C03AA03
UNII	0J48LPH2TH
EPA CompTox	DTXSID2020713

Structure


InChI Key	JZUFKLXOESDKRF-UHFFFAOYSA-N
Smiles	NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O
InChI	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C7H8ClN3O4S2
Molecular Weight	297.75
AlogP	-0.35
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	1.0
Polar Surface Area	118.36
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Pharmacology

Mechanism of Action	Action	Reference
Thiazide-sensitive sodium-chloride cotransporter inhibitor	INHIBITOR	DOI Wikipedia Wikipedia FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Lyase	-	-	-	290-394	-
Enzyme	-	-	-	290-394	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	68.94-82.24
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Anopheles gambiae	-	-	-	31.5	-
Astrosclera willeyana	-	-	-	394	-
Chionodraco hamatus	-	-	-	866	-
Colwellia psychrerythraea	-	-	-	345	-
Cricetulus griseus	-	-	-	-	68.94-82.24
Enterobacter sp.	-	-	-	133	-
Homo sapiens	-	-	-	290-328
Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	-	-	745	-
Leishmania chagasi	-	-	-	50.2	-
Leishmania donovani chagasi	-	-	-	50.2	-
Leptonychotes weddellii	-	-	-	630-630	-
Nostoc commune	-	-	-	58.7-58.7	-
Plasmodium falciparum	-	-	-	153	-
Porphyromonas gingivalis	-	-	-	380-380	-
Pseudoalteromonas haloplanktis	-	-	-	790-790	-
Sulfurihydrogenibium yellowstonense	-	-	-	7.2-7.2	-
Thiomicrospira crunogena XCL-2	-	-	-	296	-
Trypanosoma cruzi	-	-	-	134	-
Vibrio cholerae	-	-	-	68-500	-

Related Entries

Environmental Exposure

Environmental Exposure Map

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia
Sweden

Cross References

Resources	Reference
ChEBI	5778
ChEMBL	CHEMBL435
DrugBank	DB00999
DrugCentral	1385
FDA SRS	0J48LPH2TH
Human Metabolome Database	HMDB0001928
Guide to Pharmacology	4836
KEGG	C07041
PDB	HCZ
PharmGKB	PA449899
PubChem	3639
SureChEMBL	SCHEMBL9349
ZINC	ZINC000000896569

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).