GUANIDINE HYDROCHLORIDE


Trade Names	GUANIDINE HYDROCHLORIDE
Synonyms	Guanidine HCl Guanidine hydrochloride
Status
Molecule Category	Salt
UNII	3YQC9ZY4YB
EPA CompTox	DTXSID7058757


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	PJJJBBJSCAKJQF-UHFFFAOYSA-N
Smiles	Cl.N=C(N)N
InChI	InChI=1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	CH6ClN3
Molecular Weight	95.53
AlogP	-1.16
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	0.0
Polar Surface Area	75.89
Molecular species	BASE
Aromatic Rings	0.0
Heavy Atoms	4.0

Pharmacology

Mechanism of Action	Action	Reference
Voltage-gated potassium channel blocker	BLOCKER	PubMed DailyMed

Cross References

Resources	Reference
ChEBI	32735
ChEMBL	CHEMBL1200728
FDA SRS	3YQC9ZY4YB
KEGG	C17349
PDB	GAI
PubChem	5742
SureChEMBL	SCHEMBL56721
ZINC	ZINC08101126

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).