EcoDrugPlus


Trade Names	FLOXURIDINE FUDR
Synonyms	5-Fluoro-2-deoxyuridine 5-fudr F.u.d.r. FUDR Floxuridine Fluoruridine deoxyribose Fudr NSC-27640
Status
Molecule Category	Free-form
ATC	L01BC09
UNII	039LU44I5M
EPA CompTox	DTXSID3023057

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Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Smiles	O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1F
InChI	InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H11FN2O5
Molecular Weight	246.19
AlogP	-1.68
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	104.55
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Metabolites Network

Mechanism of Action	Action	Reference
Thymidylate synthase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Transferase	-	0.4-260	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	109.16-116.26
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC28 and SLC29 families of nucleoside transporters SLC28 Na+-coupled nucleoside transport family	-	-	-	-	17

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Chlorocebus sabaeus	-	-	-	-	100-100
Cricetulus griseus	-	-	-	-	109.16-116.26
Cryptosporidium parvum	5-9.6	-	-	-	-
Enterococcus faecium	-	-	-	-	95-96
Herpes simplex virus (type 1 / strain CL101)	-	-	-	-	88
Homo sapiens	3.33-15	2-960	-	-	17-41.3
Human herpesvirus 1	-	-	-	-	84.3
Mus musculus	-	0-600	-	-	95-100
Toxoplasma gondii	910-960	-	-	-	-

Target Conservation


Protein: Thymidylate synthase Description: Thymidylate synthase Organism : Homo sapiens P04818 ENSG00000176890

Cross References

Resources	Reference
ChEBI	60761
ChEMBL	CHEMBL917
DrugBank	DB00322
DrugCentral	1184
FDA SRS	039LU44I5M
Human Metabolome Database	HMDB0014467
Guide to Pharmacology	4801
KEGG	C11736
PubChem	5790
SureChEMBL	SCHEMBL4424
ZINC	ZINC000003813010

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

FLOXURIDINE

Structure

Physicochemical Descriptors

Metabolites Network

Pharmacology

Target Conservation

Related Entries

Cross References