EcoDrugPlus


Trade Names	NORTHERA
Synonyms	DOPS Droxidopa L-DOPS L-threo-dops Northera
Status
Molecule Category	Free-form
ATC	C01CA27
UNII	J7A92W69L7


InChI Key	QXWYKJLNLSIPIN-JGVFFNPUSA-N
Smiles	N[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1
InChI	InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

Property Name	Value
Molecular Formula	C9H11NO5
Molecular Weight	213.19
AlogP	-0.46
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	5.0
Number of Rotational Bond	3.0
Polar Surface Area	124.01
Molecular species	ZWITTERION
Aromatic Rings	1.0
Heavy Atoms	15.0

Mechanism of Action	Action	Reference
Adrenergic receptor agonist	AGONIST	PubMed FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I Nuclear hormone receptor subfamily 1 group I member 2	4	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	4	-	-	-	-

Resources	Reference
ChEBI	31524
ChEMBL	CHEMBL2103827
DrugBank	DB06262
DrugCentral	971
FDA SRS	J7A92W69L7
Guide to Pharmacology	7391
PubChem	92974
SureChEMBL	SCHEMBL134299
ZINC	ZINC000001482049

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

DROXIDOPA

Structure

Physicochemical Descriptors

Pharmacology

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Cross References