CROTAMITON

/static/temp/default.svg

Search structure


Trade Names	CROTAN EURAX
Synonyms	Crotamiton Crotan Eurax N-ethyl-o-crotonotoluidide N-ethylcrotono-o-toluidide NSC-758951
Status
Molecule Category	Free-form
UNII	D6S4O4XD0H
EPA CompTox	DTXSID6040664

Structure


InChI Key	DNTGGZPQPQTDQF-XBXARRHUSA-N
Smiles	C/C=C/C(=O)N(CC)c1ccccc1C
InChI	InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C13H17NO
Molecular Weight	203.28
AlogP	2.92
Hydrogen Bond Acceptor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	20.31
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	71.83-72.95

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	71.83-72.95

Cross References

Resources	Reference
CAS NUMBER	483-63-6
ChEMBL	CHEMBL1200709
FDA SRS	D6S4O4XD0H
Guide to Pharmacology	11165
PharmGKB	PA164745460
SureChEMBL	SCHEMBL32934
ZINC	ZINC000000056427

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 23^rd March 2026