CHLORPROTHIXENE


Trade Names	TARACTAN
Synonyms	Chlorprothixene N-714 N-714RO 4-0403 NSC-18720 RO 4-0403 RO-4-0403 RO-40403 Taractan Truxal
Status
Molecule Category	Free-form
ATC	N05AF03
UNII	9S7OD60EWP

Structure


InChI Key	WSPOMRSOLSGNFJ-AUWJEWJLSA-N
Smiles	CN(C)CC/C=C1/c2ccccc2Sc2ccc(Cl)cc21
InChI	InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H18ClNS
Molecular Weight	315.87
AlogP	5.19
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	3.24
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	PubMed PubMed Wikipedia Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	55.2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	-	-	2.96-18	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	1-870.96	-	3.75	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	-	-	3-5.6	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-6.9-26.6
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	65.4

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	55.2
Homo sapiens	-	1-870.96	-	2.96-18	-6.9-65.4
Rattus norvegicus	-	1.072	-	-	-

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295












Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246












Protein: Dopamine D3 receptor Description: D(3) dopamine receptor Organism : Homo sapiens P35462 ENSG00000151577

Related Entries

Cross References

Resources	Reference
ChEBI	50931
ChEMBL	CHEMBL908
DrugBank	DB01239
DrugCentral	623
FDA SRS	9S7OD60EWP
KEGG	C07953
PubChem	667467
SureChEMBL	SCHEMBL94235
ZINC	ZINC000000001137

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025