CARBAMAZEPINE


Trade Names	CARBAMAZEPINE CARBATROL CARNEXIV EPITOL EQUETRO TEGRETOL TEGRETOL-XR TERIL
Synonyms	Arbil mr Biston Carbagen sr Carbamazepine Carbamazepine anhydrous Carbamazepine extended release Carbamazepinum Carbatrol Carnexiv Epimaz Epimaz ret Epitol Equetro Finlepsin G-32883
Status
Molecule Category	Free-form
ATC	N03AF01
UNII	33CM23913M
EPA CompTox	DTXSID4022731


InChI Key	FFGPTBGBLSHEPO-UHFFFAOYSA-N
Smiles	NC(=O)N1c2ccccc2C=Cc2ccccc21
InChI	InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

Mechanism of Action	Action	Reference
Sodium channel alpha subunit blocker	BLOCKER	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	-	-	-	8
Ion channel Ligand-gated ion channel P2X receptor	-	-	-	-	35
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	1.6-64.8
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	13.3-121.62
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	8.4

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	1.6
Cricetulus griseus	-	-	-	-	99.43-121.62
Homo sapiens	-	-	-	-	8.4-35
Mus musculus	-	-	-	-	0-100
Rattus norvegicus	-	-	-	-	-2.9-64.8


Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314












Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873








Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253









Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876











Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313

CONTENTS