EcoDrugPlus


Trade Names	LASTACAFT
Synonyms	Alcaftadine Lastacaft R 89674 R-89674
Status
Molecule Category	Free-form
ATC	S01GX11
UNII	7Z8O94ECSX
EPA CompTox	DTXSID80598455

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Human Metabolites

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SubStructure

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InChI Key	MWTBKTRZPHJQLH-UHFFFAOYSA-N
Smiles	CN1CCC(=C2c3ccccc3CCn3c(C=O)cnc32)CC1
InChI	InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H21N3O
Molecular Weight	307.4
AlogP	2.78
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	1.0
Polar Surface Area	38.13
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	23.0

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	DailyMed

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	71023
ChEMBL	CHEMBL1201747
DrugBank	DB06766
DrugCentral	4165
FDA SRS	7Z8O94ECSX
Human Metabolome Database	HMDB0015670
Guide to Pharmacology	7587
PharmGKB	PA165958399
PubChem	19371515
SureChEMBL	SCHEMBL1602418
ZINC	ZINC000011726211

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ALCAFTADINE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References